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Davide De Pietri Tonelli

Senior Researcher Tenured - Principal Investigator
Neurobiology of miRNA
Phone
+39 010 2896 725
Research center
CCT@Morego
About
We aim at dissecting the molecular control of Neural Stem Cell (NSC) fate in mammalian neurogenesis by focusing on noncoding RNAs and other post-transcriprional mechanisms, as key to understand/cure brain (mal)formation, aging and tumours. Current Research in my group focuses on: i) Small RNAs in basic and translational aspects of neurogenesis in mammals ii) New technological approaches enabling oligotherapy for human brain dysfunctions
Experience External

Title: Contract Professor of “Developmental Neurobiology” for the Master degree in biotechnology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2018 To: null

Title: Contract Professor of “Neural stem cell differentiation” for the Master degree in Molecular and Cell Biology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2008 To: 2010

Title: External collaborator
Institute: Clontech inc. (Mountain View, CA, USA).
Location: Mountain View (CA)
Country: USA
From: 2006 To: 2006

Title: Researcher
Institute: Max-Planck Institute of Molecular Cell-Biology and Genetics
Location: Dresden
Country: Germany
From: 2004 To: 2008

Title: Fellow
Institute: DIBIT-San Raffaele Reserch Institute
Location: Milan
Country: Italy
From: 1999 To: 2003

Top Publications
2023
Gasperini C., Tuntevski K., Beatini S., Pelizzoli R., Lo Van A., Mangoni D., Cossu R.M., Pascarella G., Bianchini P., Bielefeld P., Scarpato M., Pons-Espinal M., Sanges R., Diaspro A., Fitzsimons C.P., Carninci P., Gustincich S., De Pietri Tonelli D.
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus
EMBO Reports
DOI 10.15252/embr.202153801
2019
Pons-Espinal M., Gasperini C., Marzi M.J., Braccia C., Armirotti A., Potzsch A., Walker T.L., Fabel K., Nicassio F., Kempermann G., De Pietri Tonelli D.
MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis
Stem Cell Reports, vol. 12, (no. 6), pp. 1298-1312
DOI 10.1016/j.stemcr.2019.04.020
2017
Barca-Mayo O., Pons-Espinal M., Follert P., Armirotti A., Berdondini L., De Pietri Tonelli D.
Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
Nature Communications, vol. 8
DOI 10.1038/ncomms14336
2017
De Pietri Tonelli D.
Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain
Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain, pp. 1-316, Publisher: Elsevier Inc.
Book Book
2017
Marinaro F., Marzi M.J., Hoffmann N., Amin H., Pelizzoli R., Niola F., Nicassio F., De Pietri Tonelli D.
MicroRNA-independent functions of DGCR8 are essential for neocortical development and TBR1 expression
EMBO Reports, vol. 18, (no. 4), pp. 603-618
DOI 10.15252/embr.201642800
All Publications
2023
Giantomasi L., Ribeiro J.F., Barca-Mayo O., Malerba M., Miele E., De Pietri Tonelli D., Berdondini L.
Astrocytes actively support long-range molecular clock synchronization of segregated neuronal populations
Scientific Reports, vol. 13, (no. 1)
DOI 10.1038/s41598-023-31966-1
Article Journal
2023
Spattini C., La Rosa L., Pereira R.C., De Pietri Tonelli D.
Efficacy of a miRNA-based differentiation therapy for human medulloblastoma investigated in a xenotransplant model in wild-type mouse embryos
EMBO|EMBL Symposium: The non-coding genome
Poster Conference
2023
Lee S.M., Koo B., Carré C., Fischer A., He C., Kumar A., Liu K., Meyer K., Ming G.L., Peng J., Roignant J.Y., Storkebaum E., Sun S., De Pietri Tonelli D., Wang Y., Weng Y.l., Pulvirenti L., Shi Y., Yoon K.J., Song H.
Exploring the Brain Epitranscriptome: Perspectives from the NSAS Summit
Frontiers in Neuroscience
DOI 10.3389/fnins.2023.1291446
Article Journal
2023
Gasperini C., Tuntevski K., Beatini S., Pelizzoli R., Lo Van A., Mangoni D., Cossu R.M., Pascarella G., Bianchini P., Bielefeld P., Scarpato M., Pons-Espinal M., Sanges R., Diaspro A., Fitzsimons C.P., Carninci P., Gustincich S., De Pietri Tonelli D.
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus
EMBO Reports
DOI 10.15252/embr.202153801
2023
Barbieri F., Bajetto A., Dellacasagrande I., Solari A., Wurth R., Fernandez V., Rancati S., Ceresa D., Appolloni I., De Luca G., Dono M., Nozza P., Schiapparelli P., Gambaro M., Fiaschi P., Gaggero G., Costanzo N., Thellung S., Malatesta P., Pagano A., Zona G., De Pietri Tonelli D., Florio T.
Stem-like signatures in human meningioma cells are under the control of CXCL11/CXCL12 chemokine activity
Neuro-Oncology, vol. 25, (no. 10), pp. 1775-1787
DOI 10.1093/neuonc/noad076
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Organized Events
2022
De Pietri Tonelli D., Nicassio F., Tartaglia GG.
Co-coordinator of the “RNA Collaborative Seminar Series” by the RNA society (USA)
2022
Prochiantz A., De Pietri Tonelli D., Gustincich S.
Co-organizer of the 1st IIT-Collège de France Joint Neuroscience Meeting
2017
De Pietri Tonelli D.
Co-organiser of the symposium: "Emerging complexity and functions of miRNAs-dependent regulation in neuroscience"
2014
De Pietri Tonelli D.
Co-organiser of the Symposium "microRNAs in brain development ad function"
2012
De Pietri Tonelli D.
Chairman and Lecturer at the Symposium "MicroRNAs in Development"
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Colleagues of Neurobiology of miRNA
Lidia Giantomasi Post Doc Neurobiology of miRNA
Cinzia Nasso Administrative Assistant Neurobiology of miRNA Neuromodulation of Cortical and Subcortical Circuits Synaptic Plasticity of Inhibitory Networks Microtechnology for Neuroelectronics Enhanced Regenerative Medicine
Rui Pereira Affiliated Researcher Neurobiology of miRNA
Carlotta Spattini PhD Student Fellow Neurobiology of miRNA
Kiril Tuntevski PhD Student Fellow Neurobiology of miRNA
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