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Davide De Pietri Tonelli

Senior Researcher Tenure Track - Principal Investigator
Neurobiology of miRNA
Research center
We aim at dissecting the molecular control of Neural Stem Cell (NSC) fate in mammalian neurogenesis by focusing on noncoding RNAs and other post-transcriprional mechanisms, as key to understand/cure brain (mal)formation, aging and tumours. Current Research in my group focuses on: i) Small RNAs in basic and translational aspects of neurogenesis in mammals ii) New technological approaches enabling oligotherapy for human brain dysfunctions
Experience External

Title: Contract Professor of “Developmental Neurobiology” for the Master degree in biotechnology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2018 To: null

Title: Contract Professor of “Neural stem cell differentiation” for the Master degree in Molecular and Cell Biology
Institute: Università di Genova
Location: Genoa
Country: italy
From: 2008 To: 2010

Title: External collaborator
Institute: Clontech inc. (Mountain View, CA, USA).
Location: Mountain View (CA)
Country: USA
From: 2006 To: 2006

Title: Researcher
Institute: Max-Planck Institute of Molecular Cell-Biology and Genetics
Location: Dresden
Country: Germany
From: 2004 To: 2008

Title: Fellow
Institute: DIBIT-San Raffaele Reserch Institute
Location: Milan
Country: Italy
From: 1999 To: 2007

All Publications
Gasperini C., Tuntevski K., Pelizzoli R., Lo Van A., Mangoni D., Cossu R.M., Pascarella G., Bianchini P., Bielefeld P., Scarpato M., Pons-Espinal M., Sanges R., Diaspro A., Fitzsimons C.P., Carninci P., Gustincich S., De Pietri Tonelli D.
The piRNA pathway sustains adult neurogenesis by repressing protein synthesis and cellular senescence
Article Journal
Hoffmann N., Fernandez V., Pereira R.C., Rancati S., Pelizzoli R., De Pietri Tonelli D.
A Xenotransplant Model of Human Brain Tumors in Wild-Type Mice
iScience, vol. 23, (no. 1)
Schouten M., Bielefeld P., Garcia-Corzo L., Passchier E.M.J., Gradari S., Jungenitz T., Pons-Espinal M., Gebara E., Martin-Suarez S., Lucassen P.J., De Vries H.E., Trejo J.L., Schwarzacher S.W., De Pietri Tonelli D., Toni N., Mira H., Encinas J.M., Fitzsimons C.P.
Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain
Molecular Psychiatry, vol. 25, (no. 7), pp. 1382-1405
Barca-Mayo O., Boender A.J., Armirotti A., De Pietri Tonelli D.
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
GLIA, vol. 68, (no. 6), pp. 1131-1147
Article Journal
Blanco M.E., Mayo O.B., Bandiera T., Tonelli D.D.P., Armirotti A.
LC–MS/MS analysis of twelve neurotransmitters and amino acids in mouse cerebrospinal fluid
Journal of Neuroscience Methods, vol. 341