I graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons supervised by Brunello Tirozzi (Physics department). Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH with Amedeo Caflisch (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011.
From 2010 and until 2020 I have been PI at the Centre for Genomic Regulation (CRG) in Barcelona directed by Miguel Beato (until 2012) and Luis Serrano (since 2012), in the research program of Roderic Guigo'. I was awarded an ERC grant in 2013 for my studies on the role of coding and non-coding transcripts in regulation of amyloid genes. In 2014 I was tenured in Catalonia as ICREA professor of Life and Medical Sciences. In December 2018 I became full professor of Biochemistry in the Department of Biology at University La Sapienza. In 2019 I started to work at IIT. In 2020 I was awarded an ERC grant for the study on the composition of phase-separated assemblies. This ERC is a Synergy grant and involves collaboration with Giancarlo Ruocco and Irene Bozzoni.
In march 2020 I became PI at IIT where I lead the RNA System Biology lab. Together with the colleagues listed at the bottom of this page, there are also Dr. Claudia Giambartolomei and Dr. Elsa Zacco from the Non-coding RNAs and RNA-based therapeutics lab. Elsa and Claudia are the pioneers of our RNA System Biology lab and joined IIT in early 2019. Jakob Rupert, PhD student from Sapienza university, is also member of Tartaglia's lab. Edoardo Milanetti, Lorenzo Di Rienzo and Mattia Miotto, previously in Anna Tramontano's group and now working at IIT CNLS with Giancarlo Ruocco are honorary members of the lab.
Since September 2020 I am MAE (Member of Academia Europaea).
Additional details here.
Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders. My laboratory works on associations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS). We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins. One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.
I received >6000 citations (>3500 in the last 5 years; 100 papers). With respect to the productivity and impact factor of my published work, my h-index is 42 (my i10-index is 75). Since I became PI in 2010, my group published > 70 articles and I am the corresponding author in 80% of all my publications. Only last year, my group published 5 papers with IF>10.
Most relevant publications (as of August 2020). See details here.
Most relevant theoretical works
Most relevant experimental works
Collaborations on aggregation of RNA-binding proteins
Research monographs, chapters in collective volumes