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Gian Gaetano Tartaglia

Principal Investigator
Researcher - Principal Investigator
RNA Systems Biology
Phone
Address
Research center
About
I graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons supervised by Brunello Tirozzi (Physics department). Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH with Amedeo Caflisch (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011. From 2010 and until 2020 I have been PI at the Centre for Genomic Regulation (CRG) in Barcelona directed by Miguel Beato (until 2012) and Luis Serrano (since 2012), in the research program of Roderic Guigo'. I was awarded an ERC grant in 2013 for my studies on the role of coding and non-coding transcripts in regulation of amyloid genes. In 2014 I was tenured in Catalonia as ICREA professor of Life and Medical Sciences. In December 2018 I became full professor of Biochemistry in the Department of Biology at University La Sapienza. In 2019 I started to work at IIT. In 2020 I was awarded an ERC grant for the study on the composition of phase-separated assemblies. This ERC is a Synergy grant and involves collaboration with Giancarlo Ruocco and Irene Bozzoni. In march 2020 I became PI at IIT where I lead the RNA System Biology lab. Together with the official members of the group, there are also Dr. Claudia Giambartolomei and Dr. Elsa Zacco from the Non-coding RNAs and RNA-based therapeutics lab. Elsa and Claudia are the pioneers of our RNA System Biology lab and joined IIT in early 2019. Jakob Rupert, PhD student from Sapienza university, is also member of Tartaglia's lab. Edoardo Milanetti, Lorenzo Di Rienzo and Mattia Miotto, previously in Anna Tramontano's group and now working at IIT CNLS with Giancarlo Ruocco are honorary members of the lab. Since September 2020 I am MAE (Member of Academia Europaea).
Education

Title: Clare Hall Research Fellow - Genetics and Chemistry
Institute: University of Cambridge
Location: Cambridge
Country: UK
From: 2007 To: 2010

Title: PhD - Biochemistry
Institute: University of Zurch
Location: Zuerich
Country: Switzerland
From: 2001 To: 2006

Title: MSc - Physics
Institute: University of Rome Sapienza
Location: Rome
Country: Italy
From: 1996 To: 2000

Skills

Protein-RNA Networks

Phase Separation

RNA Viruses

Computational Modelling

RNA Chemistry

All Publications
2020
Rendon J.M., Lang B., Tartaglia G.G., Burgas M.T.
BacFITBase: A database to assess the relevance of bacterial genes during host infection
Nucleic Acids Research, vol. 48, (no. D1), pp. D511-D516
2020
Ponti R.D., Armaos A., Vandelli A., Tartaglia G.G.
CROSSalive: A web server for predicting the in vivo structure of RNA molecules
Bioinformatics, vol. 36, (no. 3), pp. 940-941
2020
CONRAD T., NTINI E., LANG B., COZZUTO L., ANDERSEN J.B., MARQUARDT J.U., PONOMARENKO J., TARTAGLIA G.G., OROM U.A.V.
Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing
RNA, vol. 26, (no. 11), pp. 1726-1730
2020
Rea J., Menci V., Tollis P., Santini T., Armaos A., Garone M.G., Iberite F., Cipriano A., Tartaglia G.G., Rosa A., Ballarino M., Laneve P., Caffarelli E.
HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade
Cell Death and Disease, vol. 11, (no. 7)
2020
Haify S.N., Botta-Orfila T., Hukema R.K., Tartaglia G.G.
In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome
Frontiers in Molecular Biosciences, vol. 7
Scientific talk
2020
Armaos A., Giambartolomei C., Tartaglia G.G.
Reconstructing protein interactions at enhancer-promoter regions in prostate cancer
American Society of Human Genetics
Conference
2020
Vandelli A., Tartaglia G.G.
Structural analysis of SARS-CoV-2 genome and predictions of the human interactome
Doctorate School UPF Barcelona
School (Summer school, ...)
2020
Tartaglia G.G.
The role of non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
Brixen Biophysics meeting http://www0.mi.infn.it/~tiana/bressanone-20/Welcome.html?fbclid=IwAR2qvkqzyEfq3Y-4wwfQ6Ni2oJHQEEnRT_pB8oqyR_6geS5wI0nLMqu9Onw
Workshop/Symposium
2020
Tartaglia G.G.
The role of non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
Research Conference on (Epi-)Genome Architecture https://osr.kaust.edu.sa/crf/Conferences/Pages/Genome-Architecture-and-Function.aspx
Conference
2019
Tartaglia G.G.
Aggregation, RNA-binding ability and Neurodegeneration
Universita degli Studi di Roma La Sapienza
Institute
Award Achievement
2020
Tartaglia G.G.
ERC Award
2020
Tartaglia G.G.
Member of Academia Europaea
2018
Tartaglia G.G.
Full Professor
2014
Tartaglia G.G.
ICREA Professor
2013
Tartaglia G.G.
ERC