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Andrea Armirotti

Head of Analytical Chemistry


Analytical Chemistry Lab


Analytical Chemistry and in vivo Pharmacology


+39 010 2896 938
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Born in Genova (Italy),  September 14, 1973

-Bachelor in  Sciences obtained at the Liceo Ginnasio XVI febbraio in Aosta (July, 1992)

 -Doctoral degree in Chemistry (Laurea) (June 22, 2002) obtained at the University of Genova .(Experimental thesis:   "GC-MS analysis of N-linked oligosaccharides" )

-Professional Certificate for Chemists obtained at the University of Genova (December 2002).

-PhD in Biochemistry (May 10, 2006) obtained at the University of Genova. Ph.D thesis: "Extraction and chemical characterization of taxanes from in vitro cell coltures "


Selected Publications


  • Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions.Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, Moreno-Sanz G, Reggiani A, Piomelli D.Pharmacol Res. 2012 May;65(5):553-63. Epub 2012 Mar 7.
  • A catalytically silent FAAH-1 variant drives anandamide transport in neurons.Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D.Nat Neurosci. 2011 Nov 20;15(1):64-9.
  • Searching for a therapy of creatine transporter deficiency: some effects of creatine ethyl ester in brain slices in vitro.Adriano E, Garbati P, Damonte G, Salis A, Armirotti A, Balestrino M.Neuroscience. 2011 Dec 29;199:386-93. Epub 2011 Sep 19.
  • Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosismutations.Pedemonte N, Tomati V, Sondo E, Caci E, Millo E, Armirotti A, Damonte G, Zegarra-Moran O, Galietta LJ.J Biol Chem. 2011 Apr 29;286(17):15215-26.
  • Achievements and perspectives of top-down proteomics.Armirotti A, Damonte G.Proteomics. 2010 Oct;10(20):3566-76. Review.
  • Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses.Parakkottil Chothi M, Duncan GA, Armirotti A, Abergel C, Gurnon JR, Van Etten JL, Bernardi C, Damonte G, Tonetti M.J Virol. 2010 Sep;84(17):8829-38.
  • Bottom-Up Proteomics Armirotti A. Review Current Analytical Chemistry 2009 5:84 
  • Comparison of temsirolimus pharmacokinetics in patients with renal cell carcinoma not receiving dialysis and those receiving hemodialysis: a case series.Lunardi G, Armirotti A, Nicodemo M, Cavallini L, Damonte G, Vannozzi MO, Venturini M.Clin Ther. 2009 Aug;31(8):1812-9.
  • Primary structure and post-translational modifications of silicatein beta from the marine sponge Petrosia ficiformis (Poiret, 1789).Armirotti A, Damonte G, Pozzolini M, Mussino F, Cerrano C, Salis A, Benatti U, Giovine M.J Proteome Res. 2009 Aug;8(8):3995-4004.
  • Top-down proteomics with a quadrupole time-of-flight mass spectrometer and collision-induced dissociation.Armirotti A, Benatti U, Damonte G.Rapid Commun Mass Spectrom. 2009 Mar;23(5):661-6.
  • Temsirolimus in patients with renal cancer on hemodialysis.Lunardi G, Vannozzi MO, Armirotti A, Nicodemo M, Venturini M, Cavallini L.J Clin Oncol. 2008 Dec 1;26(34):5652-3; author reply 5653-4.
  • Structural characterization of the As/Sb reductase LmACR2 from Leishmania major.Mukhopadhyay R, Bisacchi D, Zhou Y, Armirotti A, Bordo D.J Mol Biol. 2009 Mar 13;386(5):1229-39.
  • Taxanes from Shells and Leaves of Corylus avellana.Ottaggio L, Bestoso F, Armirotti A, Balbi A, Damonte G, Mazzei M, Sancandi M, Miele M.J Nat Prod. 2008 Jan;71(1):58-60.
  • Electrospray ionization ion trap multiple-stage mass spectrometric fragmentation pathways of leucine and isoleucine: an ab initio computational study.Armirotti A, Scapolla C, Benatti U, Damonte G.Rapid Commun Mass Spectrom. 2007;21(19):3180-4.
  • Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.Massone S, Argellati F, Passalacqua M, Armirotti A, Melone L, d'Abramo C, Marinari UM, Domenicotti C, Pronzato MA, Ricciarelli R.Biochem Biophys Res Commun. 2007 Oct 26;362(3):633-8.
  • Association of a presenilin 1 S170F mutation with a novel Alzheimer disease molecular phenotype.Piccini A, Zanusso G, Borghi R, Noviello C, Monaco S, Russo R, Damonte G, Armirotti A, Gelati M, Giordano R, Zambenedetti P, Russo C, Ghetti B, Tabaton M.Arch Neurol. 2007 May;64(5):738-45.
  • Purification and HPLC-MS analysis of a naturally processed HCMV-derived peptide isolated from the HEK-293T/HLA-E+/Ul40+ cell transfectants and presented at the cell surfacein the context of HLA-E.Millo E, Pietra G, Armirotti A, Vacca P, Mingari MC, Moretta L, Damonte G.J Immunol Methods. 2007 Apr 30;322(1-2):128-36.
  • In vitro cell cultures obtained from different explants of Corylus avellana produce Taxol and taxanes.Bestoso F, Ottaggio L, Armirotti A, Balbi A, Damonte G, Degan P, Mazzei M, Cavalli F, Ledda B, Miele M.BMC Biotechnol. 2006 Dec 6;6:45.
  • How to discriminate between leucine and isoleucine by low energy ESI-TRAP MSn.Armirotti A, Millo E, Damonte G.J Am Soc Mass Spectrom. 2007 Jan;18(1):57-63.
  • Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.De Chiara G, Marcocci ME, Torcia M, Lucibello M, Rosini P, Bonini P, Higashimoto Y, Damonte G, Armirotti A, Amodei S, Palamara AT, Russo T, Garaci E, Cozzolino F.J Biol Chem. 2006 Jul 28;281(30):21353-61.
  • Matrix-assisted laser desorption/ionization mass spectrometry of taxanes.Armirotti A, Benatti U, Miele M, Damonte G.Rapid Commun Mass Spectrom. 2005;19(23):3531-8.
  • ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells.Basile G, Taglialatela-Scafati O, Damonte G, Armirotti A, Bruzzone S, Guida L, Franco L, Usai C, Fattorusso E, De Flora A, Zocchi E.Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14509-14.
  • Beta-amyloid is different in normal aging and in Alzheimer disease.Piccini A, Russo C, Gliozzi A, Relini A, Vitali A, Borghi R, Giliberto L, Armirotti A, D'Arrigo C, Bachi A, Cattaneo A, Canale C, Torrassa S, Saido TC, Markesbery W, Gambetti P,Tabaton M.J Biol Chem. 2005 Oct 7;280(40):34186-92.
  • The "rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: crystal structure of SseA from Escherichia coli.Spallarossa A, Forlani F, Carpen A, Armirotti A, Pagani S, Bolognesi M, Bordo D.J Mol Biol. 2004 Jan 9;335(2):583-93.
  • Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.Tonetti M, Zanardi D, Gurnon JR, Fruscione F, Armirotti A, Damonte G, Sturla L, De Flora A, Van Etten JL.J Biol Chem. 2003 Jun 13;278(24):21559-65.


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