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Sine Mandrup Bertozzi

Analytical Chemistry Facility
Senior Technician
Analytical Chemistry
Phone
Research center
About

I hold a Master Degree in Chemical Engineering (2000) from the Department of Organic Chemistry at the Technical University of Denmark - DTU (Denmark). I have a background in the pharmaceutical industry, where I have been working as a synthetic organic/medicinal chemist in Early Drug Discovery at Novartis Pharma (Switzerland) and ACADIA Pharmaceuticals (Denmark), and also in R&D at PolyPeptide Laboratories (Denmark). In 2005, I embarked on a career in the analytical chemistry field providing support to the medicinal chemistry in early drug discovery projects at ACADIA Pharmaceuticals (Sweden). In 2010, I joined IIT as a Senior Technician in the Drug Discovery and Development (D3) Department, where I have been part of setting up the analytical chemistry and biochemistry lab. Within the Analytical Chemistry Facility, I am responsible for in vitro DMPK profiling, chemical characterization and purification of compounds for research projects within IIT and external collaborations. I have co-authored 33 publications in peer-reviewed journals.


Education

Title: M.Sc. in Chemical Engineering
Institute: Technical University of Denmark (DTU)
Location: Kgs. Lyngby
Country: Denmark
From: 1993 To: 2000

All Publications
2023
Brindani N., Vuong L.M., Acquistapace I.M., La Serra M.A., Ortega J.A., Veronesi M., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., Ganesan A.K., De Vivo M.
Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer
Journal of Medicinal Chemistry
Article Journal
2023
Basagni F., Ortega J.A., Bertozzi S.M., Armirotti A., Summa M., Bertorelli R., Bartolini M., Mellor I.R., Bedeschi M., Bottegoni G., Lembo V., Minarini A., Cavalli A., Rosini M.
Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties
European Journal of Medicinal Chemistry, vol. 261
2023
Bellina F., Berti F., Bertozzi S. M., Bandiera T., Bertozzi F.
Highly diastereoselective Heck-Matsuda reaction with pyrazolyl diazonium salts
New Journal of Chemistry
Article in Press Journal
2023
Scarpelli R., Palomba M., Vecchio D., Ottonello G., Mandrup Bertozzi S., Summa M., Armirotti A., Bertorelli R., De Mei C., Grimaldi B.
Identification of a dual REV-ERBβ and autophagy inhibitor with in vivo anticancer efficacy (P222)- September 3-7, 2023, Zagreb (Croatia)
IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
Poster Conference
2023
Stuefer A., Balasco L., Gini S., Coletta L., Rocchi F., Montani C., Alvino F.G., Sastre D., Galbusera A., Aldrighetti M., Mandrup Bertozzi S., Lau Poui Cheung P., Vozzi D., Papaleo F., Iurilli G., Armirotti A., Cancedda L., Lombardo M., Bozzi Y., Gozzi A.
Transient neocortical excitatory / inhibitory imbalance during early infancy leads to permanent social impairments
Neurobiology of social behaviors
Poster Conference