Giorgio Grasselli is Associate Professor of Physiology at the University of Genoa (Dept. of Pharmacy) and Affiliated Scientist at the Italian Institute of Technology and San Martino Hospital in Genoa.
His team is studying neuronal physiology and plasticity at different levels (structural and functional, at the synaptic level as well as looking at intrinsic excitability) using the cerebellum as a model area, to better understand the mechanisms used in this circuit to encode information and memory. We also investigate pathological alterations of the structure and function of this circuit in brain diseases such as multiple sclerosis, autism and other neuropathologies.
RESEARCH TOPICS
neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
learning and memory
physiology and pathophysiology of the cerebellum
multiple sclerosis
cerebellar ataxia
autism
neuropsychiatric disorders
MAIN EXPERIMENTAL METHODS
patch-clamp electrophysiology in acute brain slices and primary neuronal cultures
in vivo microinjections
viral vectors for gene expression/silencing
immunohistochemistry
fluorescent/confocal microscopy and morphometric analysis
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Giorgio Grasselli is Associate Professor of Physiology at the University of Genoa (Dept. of Pharmacy) and Affiliated Scientist at the Italian Institute of Technology and San Martino Hospital in Genoa.
His team is studying neuronal physiology and plasticity at different levels (structural and functional, at the synaptic level as well as looking at intrinsic excitability) using the cerebellum as a model area, to better understand the mechanisms used in this circuit to encode information and memory. We also investigate pathological alterations of the structure and function of this circuit in brain diseases such as multiple sclerosis, autism and other neuropathologies.
RESEARCH TOPICS
neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
learning and memory
physiology and pathophysiology of the cerebellum
multiple sclerosis
cerebellar ataxia
autism
neuropsychiatric disorders
MAIN EXPERIMENTAL METHODS
patch-clamp electrophysiology in acute brain slices and primary neuronal cultures
in vivo microinjections
viral vectors for gene expression/silencing
immunohistochemistry
fluorescent/confocal microscopy and morphometric analysis
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Giorgio Grasselli is Associate Professor of Physiology at the University of Genoa (Dept. of Pharmacy) and Affiliated Scientist at the Italian Institute of Technology and San Martino Hospital in Genoa.
His team is studying neuronal physiology and plasticity at different levels (structural and functional, at the synaptic level as well as looking at intrinsic excitability) using the cerebellum as a model area, to better understand the mechanisms used in this circuit to encode information and memory. We also investigate pathological alterations of the structure and function of this circuit in brain diseases such as multiple sclerosis, autism and other neuropathologies.
RESEARCH TOPICS
neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
learning and memory
physiology and pathophysiology of the cerebellum
multiple sclerosis
cerebellar ataxia
autism
neuropsychiatric disorders
MAIN EXPERIMENTAL METHODS
patch-clamp electrophysiology in acute brain slices and primary neuronal cultures
in vivo microinjections
viral vectors for gene expression/silencing
immunohistochemistry
fluorescent/confocal microscopy and morphometric analysis
Giorgio Grasselli is Associate Professor of Physiology at the University of Genoa (Dept. of Pharmacy) and Affiliated Scientist at the Italian Institute of Technology and San Martino Hospital in Genoa.
His team is studying neuronal physiology and plasticity at different levels (structural and functional, at the synaptic level as well as looking at intrinsic excitability) using the cerebellum as a model area, to better understand the mechanisms used in this circuit to encode information and memory. We also investigate pathological alterations of the structure and function of this circuit in brain diseases such as multiple sclerosis, autism and other neuropathologies.
RESEARCH TOPICS
neuronal plasticity (structural and functional, at the synaptic level as well as looking at intrinsic excitability),
learning and memory
physiology and pathophysiology of the cerebellum
multiple sclerosis
cerebellar ataxia
autism
neuropsychiatric disorders
MAIN EXPERIMENTAL METHODS
patch-clamp electrophysiology in acute brain slices and primary neuronal cultures
in vivo microinjections
viral vectors for gene expression/silencing
immunohistochemistry
fluorescent/confocal microscopy and morphometric analysis
Title: PhD in Cellular and Molecular Biology Institute: University of Rome Tor Vergata Location: Rome Country: Italy From: 2006 To: 2010
Title: MSc in Cellular and Molecular Biology Institute: University of Rome Tor Vergata Location: Rome Country: Italy From: 2004 To: 2006
Title: BSc in Cellular and Molecular Biology Institute: University of Rome Tor Vergata Location: Rome Country: Italy From: 2001 To: 2004
Certificate
Title: Italian Scientific Habilitation to Associate Professor (ASN II fascia), Italian Ministry of Education (MIUR) Description: Molecular Biology (05/E2, 05/2019), Physiology (05/D1, 03/2018), General pathology (06/A2, 03/2018), Histology (05/H2, 03/2018), Applied Biology (05/F1, 07/2017) Date: 01-07-2017
Title: French Qualification to Associate Professor (HDR, Maître de conférences), French Ministry of Education (MENJS) Description: Section: Neuroscience (69) Date: 10-03-2021
Experience External
Title: Associate Professor Institute: University of Genoa Location: Genova Country: Italy From: 2024 To: null
Title: Assistant Professor (Tenure-track, Ricercatore "B") Institute: University of Genoa Location: Genoa Country: Italy From: 2021 To: 2024
Title: Adjunct Professor (Professore a Contratto) Institute: University of Genoa Location: Genoa Country: Italy From: 2019 To: 2021
Title: Adjunct Professor (Professore a Contratto) Institute: Humanitas University Location: Milan Country: Italy From: 2019 To: 2020
Title: Staff Scientist Institute: University of Chicago Location: Chicago Country: USA From: 2017 To: 2018
Title: Postdoctoral Scholar Institute: University of Chicago Location: Chicago Country: USA From: 2011 To: 2017
Title: Post-doc Institute: Fondazione Santa Lucia IRCCS Location: Rome Country: Italy From: 2010 To: 2011
Title: Visiting Student Institute: RIKEN Brain Science Institute (BSI) Location: Wako-shi Country: Japan From: 2008 To: 2008
Title: PhD Student Institute: Fondazione Santa Lucia IRCCS Location: Rome Country: Italy From: 2006 To: 2009
Title: Visiting student Institute: Leibniz Institute for Neurobiology Location: Magdeburg Country: Germany From: 2005 To: 2005
Skills
Electrophysiology and functional imaging - whole-cell somatic patch-clamp in acute brain slices - quantitative live confocal calcium imaging in spines and dendrites combined with patch-clamp
Grasselli G., Rossi S., Musella A., Gentile A., Loizzo S., Muzio L., Di Sanza C., Errico F., Musumeci G., Haji N., Fresegna D., Sepman H., De Chiara V., Furlan R., Martino G., Usiello A., Mandolesi G., Centonze D.
Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis
British Journal of Pharmacology, vol. 168, (no. 2), pp. 502-517
Musto M., Bergamini M., La Terra A., Marenco G., Marte A., Benfenati F., Grasselli G.
Activity-dependent structural plasticity reshapes cerebellar climbing fiber morphology and connectivity
Annual Meeting of the Society for Neuroscience 2022
PosterConference
2022
Bergamini M., Musto M., La Terra A., Marte A., Benfenati F., Grasselli G.
Cerebellar climbing fiber activity can reshape the structure of the olivocerebellar circuit
FENS Forum 2022
PosterConference
2022
Bergamini M., Musto M., La Terra A., Marte A., Benfenati F., Grasselli G.
Cerebellar climbing fiber activity can reshape the structure of the olivocerebellar circuit
SINS PhD students meeting
PosterConference
2022
Bergamini M., Natali G., Musto M., Carlini F., Kerlero deRosbo N., Palmerio F., Michetti C., La Terra A., Cesca F., Uccelli A., Benfenati F., Grasselli G.
Neuronal excitability as a potential therapeutical target for Multiple Sclerosis
2nd Scientific Retreat of San Martino Hospital IRCCS
