IIT People Search

Sine Mandrup Bertozzi

Analytical Chemistry Facility
Senior Technician
Analytical Chemistry
Phone
Research center
About

I hold a Master Degree in Chemical Engineering (2000) from the Department of Organic Chemistry at the Technical University of Denmark - DTU (Denmark). I have a background in the pharmaceutical industry, where I have been working as a synthetic organic/medicinal chemist in Early Drug Discovery at Novartis Pharma (Switzerland) and ACADIA Pharmaceuticals (Denmark), and also in R&D at PolyPeptide Laboratories (Denmark). In 2005, I embarked on a career in the analytical chemistry field providing support to the medicinal chemistry in early drug discovery projects at ACADIA Pharmaceuticals (Sweden). In 2010, I joined IIT as a Senior Technician in the Drug Discovery and Development (D3) Department, where I have been part of setting up the analytical chemistry and biochemistry lab. Within the Analytical Chemistry Facility, I am responsible for in vitro DMPK profiling, chemical characterization and purification of compounds for research projects within IIT and external collaborations. I have co-authored 29 publications in peer-reviewed journals.


Education

Title: M.Sc. in Chemical Engineering
Institute: Technical University of Denmark (DTU)
Location: Kgs. Lyngby
Country: Denmark
From: 1993 To: 2000

All Publications
2022
Tuccinardi D., Di Mauro A., Lattanzi G., Rossini G., Monte L., Beato I., Spiezia C., Bravo M., Watanabe M., Soare A., Kyanvash S., Armirotti A., Bertozzi S.M., Gastaldelli A., Pedone C., Khazrai Y.M., Pozzilli P., Manfrini S.
An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: A double-blind, cross-over, randomised controlled trial
Diabetes/Metabolism Research and Reviews, vol. 38, (no. 2)
Article Journal
2022
Jahid S., Ortega J.A., Vuong L.M., Acquistapace I.M., Hachey S.J., Flesher J.L., La Serra M.A., Brindani N., La Sala G., Manigrasso J., Arencibia J.M., Bertozzi S.M., Summa M., Bertorelli R., Armirotti A., Jin R., Liu Z., Chen C.-F., Edwards R., Hughes C.C.W., De Vivo M., Ganesan A.K.
Erratum: Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer (Cell Reports (2022) 39(1), (S221112472200393X), (10.1016/j.celrep.2022.110641))
Cell Reports, vol. 39, (no. 4)
2022
Colini Baldeschi A., Zattoni M., Vanni S., Nikolic L., Ferracin C., La Sala G., Summa M., Bertorelli R., Bertozzi S.M., Giachin G., Carloni P., Bolognesi M.L., De Vivo M., Legname G.
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
Journal of Medicinal Chemistry, vol. 65, (no. 13), pp. 8998-9010
Article Journal
2022
Jahid S., Ortega J. A., Vuong L. M., Hachey S. J., Flesher J. L., La Serra M. A., Brindani N., La Sala G., Manigrasso J., Arencibia J. M., Bertozzi S. M., Summa M., Bertorelli R., Armirotti A., Chen C., Hughes C. C. W., Edwards R., De Vivo M., Ganesan A. K.
Structure-based Design of CDC42 Effector Interaction Inhibitors For the Treatment of Cancer
Cell Reports, vol. 39, pp. 110641
2021
Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229