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Francesco Papaleo

Senior Researcher Tenured - Principal Investigator
Genetics of Cognition
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Address
Research center
Interests
About

EDUCATION / WORK EXPERIENCE

April 2019- present: Tenured Senior Researcher, Neuroscience Area, Istituto Italiano di Tecnologia, Genova, Italy.

January 2013- present: Adjunct Faculty Investigator, Lieber Institute for Brain Development. Baltimore, MD, USA.

February 2014- March 2019: Senior Researcher, Associate Professor level, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy.

December 2011- February 2014: Assistant Professor, Department of Pharmacological Sciences, University of Padova, Italy.

September 2010- February 2014: Tenure Track-1, Team Leader, Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova, Italy.

September 2005- August 2010: Post Doctoral Fellow, Clinical Brain Disorders Branch, National Institute of Mental Health, NIH, Bethesda, USA. Supervisors: Dr. Daniel R. Weinberger and Dr. Jacqueline N. Crawley.

July 2004- December 2004: Researcher, University of Bordeaux, France. Supervisors: Prof. Antoine Tabarin and Dr. Angelo Contarino.

September 2003- July 2004: Researcher, INSERM Unit 588, “Laboratoire de Physiopathologie du Comportement”, Bordeaux, France. Supervisors: Dr. Pier Vincenzo Piazza and Dr. Angelo Contarino.

January 2002- March 2005: PhD Student in Pharmacology and Toxicology, University of Padova, Italy. Supervisor: Dr. Angelo Contarino.

December 2000- November 2001: Pharmacist. S. Chiara pharmacy. Vicenza, Italy. Supervisor: Dr. Paolo Pretto.

October 1996- November 2001: Pharmacy graduate studies (110/110 cum Laude), University of Padova, Italy.


GRANTS

≈June 2021- June 2024: Co-PI, work package leader. AIFA (Agenzia Italiana del Farmaco). Title: “Cannabidiol as an add-on treatment to substance abuse in juvenile patients with psychosis: a double-blind randomized placebo-controlled study (CAT-PSY)”. 488792 €.

October 2020- October 2022: Principal Investigator. Research collaboration agreement with Friedrich Miescher Institute for Biomedical Research, Switzerland. Title: “Use of an innovative conditional D2-receptor knockout approach, coupled to time- and cell type-specific viral delivery to identify the critical targets in the mouse model LgDel”. 350000 €.

February 2020- January 2024: Principal Investigator. Fondazione Telethon – project GGP19103, title: “Improving developmental trajectories in 22q11.2 deletion syndrome by oxytocin: focus on anti-inflammatory effects”. 419000 €.

November 2018- March 2023: Principal Investigator. Ricerca Finalizzata Giovani Ricercatori 2016 - Ministero Salute – project GR-2016-02362413, title: “Dysbindin-antipsychotics psychophamarcogenetics: a mouse-human translational study towards personalized healthcare in bipolar disorders”. 449991 €.

July 2018- April 2021: Principal Investigator. Boehringer Ingelheim Pharma. Title: “Role of the frontocortical-parvalbumin system in higher-order cognitive functions and in the onset of cognitive deficits induced by schizophrenia-relevant mutations”. 290000 €.

September 2018- September 2020: Supervisor and hosting lab. Marie Sklodowska-Curie individual Fellowships to Celine Devroye. Grant N. 796244. SocialBrainCircuits. 168277 €.

October 2018: Principal Investigator. The MINDDS Action of the European COST Association (eCOST). Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”. 25000 €.

March 2016- December 2018: Principal Investigator. Compagnia di San Paolo grant n. 2015-0321. Title: “Utilizzo di variazioni genetiche in dysbindin-1 (dtnbp1) per lo sviluppo di trattamenti più efficaci e personalizzati per la schizofrenia”. 152000 €.

September 2015- March 2018: Principal Investigator. Brain & Behavior Research Foundation, 2015 NARSAD Independent Investigator grant n. 23234; Title: “Use of genetic-driven dysbindin-1 (DTNBP1) variations for more effective and personalized treatments in First Episode of Psychosis”. 100000 $.

January 2013- January 2017: Principal Investigator. Roche Postdoc Fellowship Program; title: “D2L/S-dysbindin genetic interaction: towards early detection and personalized interventions for cognitive deficits and schizophrenia”. 400000 €.

January 2014- December 2015: in charge of a work package. 2013 NARSAD Young Investigator grant. Title: “Indicated prevention with long-chain polyunsaturated omega-3 fatty acids in patients with 22q11 microdeletion syndrome genetically at high risk for psychosis: A randomised, double blind, placebo-controlled treatment trial”. 60000 €.

January 2013- May 2016: Principal Investigator. Ricerca Finalizzata Giovani Ricercatori 2010 - Ministero Salute – project GR-2010-2315883, title: “Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models”. 280000 €.

September 2010- September 2014: Principal Investigator. Marie Curie FP7-Reintegration-Grants Call identifier: FP7-PEOPLE-2010-RG Grant n.268247 – SCHIZOGENES. 100000 €.

August 2008-August 2010: Principal Investigator. NIHM Julius Axelrod Memorial Fellowship Training Award. Behavioral characterization of genetically modified mice for schizophrenia-associated susceptibility genes.


AWARDS AND HONORS

October 2018: Scientific Director and Organizer of the Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”. Genova, Italy.

December 2017: travel award, ACNP 56th Annual Meeting, USA.

July 2017: Scientific Director and Organizer of the International Summer School of Neuroscience. Noto, Italy.

March 2015: Spring 2015 JOVE/Med Associates Competition.

April 2014: the Marie Curie Alumni Association.

November 2012: Winter Conference on Brain Research Travel Fellowship Award.

May 2009: Award as Preceptor, Howard Hughes Medical Institute Student Internship Program.

August 2008: NIMH Julius Axelrod Memorial Fellowship Training Award.

May 2008: Award as Preceptor, Howard Hughes Medical Institute Student Internship Program.

May 2007: Mentor to prize winner, American Academy of Neurology, Neuroscience Research Prize.


PROFESSIONAL SOCIETIES & SCIENTIFIC COMMITTEE

2018- : The Association for the Study of Animal Behaviour

2013- : Societa' Italiana di Farmacologia

2012- : Schizophrenia International Research Society

2012- : The Marie Curie Alumni Association

2008- : International Behavioral Neuroscience Society

2004- : Society for Neuroscience


2021- : Scientific Programme Committee, European College of Neuropsychopharmacology (ECNP)

2020- : Scientific Committeee of the IIT IACUC (Institutional Animal Care and Use Committee).


Education

Title: PhD Student in Pharmacology
Institute: University of Padova and University of Bordeaux
Location: Padova & Bordeaux
Country: Italy & France
From: 2002 To: 2005

Title: Pharmacy graduate studies
Institute: University of Padova
Location: Padova
Country: Italy
From: 1996 To: 2001

Experience External

Title: Post Doctoral Fellow
Institute: National Institute of Mental Health, NIH
Location: Bethesda
Country: USA
From: 2005 To: 2010

All Publications
2021
Torrisi S.A., Lavanco G., Maurel O.M., Gulisano W., Laudani S., Geraci F., Grasso M., Barbagallo C., Caraci F., Bucolo C., Ragusa M., Papaleo F., Campolongo P., Puzzo D., Drago F., Salomone S., Leggio G.M.
A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice
Neurobiology of Stress, vol. 14
Article Journal
2020
Pagani M., De Felice A., Montani C., Galbusera A., Papaleo F., Gozzi A.
Acute and Repeated Intranasal Oxytocin Differentially Modulate Brain-wide Functional Connectivity
Neuroscience, vol. 445, pp. 83-94
Article Journal
2020
Scarsi F., Scheggia D., Papaleo F.
Automated Two-Chamber Operon ID/ED Task for Mice
Current Protocols in Neuroscience, vol. 94, (no. 1)
Article Journal
2020
Torrisi S.A., Laudani S., Contarini G., De Luca A., Geraci F., Manago F., Papaleo F., Salomone S., Drago F., Leggio G.M.
Dopamine, cognitive impairments and second-generation antipsychotics: From mechanistic advances to more personalized treatments
Pharmaceuticals, vol. 13, (no. 11), pp. 1-14
2020
More L., Lauterborn J.C., Papaleo F., Brambilla R.
Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders
Neuroscience and Biobehavioral Reviews, vol. 110, pp. 28-45
Dissemination
2019
Papaleo F.
Disturbi Cognitivi: verso terapie ad personam.
Venerdi della cultura al CREAMCAFE. Genova, March 2019.
Outreach
2018
Papaleo F.
Clinical and preclinical translational research in psychiatric disorders.
Workshop in Precision Medicine for dysfunctions in cognitive and social processes.
Outreach
2018
Papaleo F.
“Marcatori genetici per la medicina personalizzata nelle psicosi e nelle schizofrenie”
Seminar for psychiatrists, medical doctors, nurses, patients’ and families’ associations. Organized by Kaleidos & iSPS Lombardia. Bergamo, June 2018.
Outreach
2016
Papaleo F.
Translational Studies in Mice to Unravel the Genetics of Higher-Order Cognitive Functions
Lessons for undergraduate students, Genova and Padova. 2014-2016.
Outreach
2015
Papaleo F.
Alla ricerca di terapie personalizzate per il trattamento della schizofrenia: genetica
Caffe’ Scientifici, Pasticceria Liquoreria Marescotti di Cavo, Genova. December 2015.
Public Event
Scientific Talks
2020
Papaleo F.
Circuits of Emotion Discrimination.
NeuroCentre Magendie, Bordeaux Neurocampus. Bordeaux, France (January 2020)
Institute
2020
Papaleo F.
Mouse-Human Studies of Cognitive Control
FENS 2020 Virtual Forum
Conference
2020
Papaleo F.
Mouse-Human Studies of Cognitive Control and Social Cognition
University of Verona
Workshop/Symposium
2020
Papaleo F.
Mouse-Human Studies of Cognitive Control and Social Cognition.
The Synapsy Conference on the Neurobiology of Mental Health. Geneva, Switzerland (February 2020)
Conference
2020
Papaleo F.
Perinatal Antinflammatory Oxytocin Effects Ameliorates Developmental Trajectories in 22q11.2 Deletion Syndrome
Swiss Institute of Allergy and Asthma Research (SIAF). University of Zurich.
Institute
Award and Achievements
2020
Papaleo F.
Committee scientific member of the IIT IACUC (Institutional Animal Care and Use Committee), or OPBA (Organismo preposto al benessere degli animali)
2017
Papaleo F.
travel award, ACNP 56th Annual Meeting, USA
2015
Papaleo F.
Spring 2015 JOVE/Med Associates Competition.
2014
Papaleo F.
the Marie Curie Alumni Association Travel Grant
2012
Papaleo F.
Winter Conference on Brain Research Travel Fellowship Award.
Editorships
2012-2012
Papaleo F.
CNS & Neurological Disorders-Drug Targets
Organized Events
2018
Papaleo F.
Training school/hands-on workshop in “Convergence Neuroscience: bridging the gap between human patients and animal models of neurodevelopmental disorders”
2017
Papaleo F.
Scientific Director and Organizer of the International Summer School of Neuroscience. Noto, Italy.