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Benedetto Grimaldi

Senior Researcher Tenured - Principal Investigator
Molecular Medicine
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About

Dr. Benedetto Grimaldi obtained in 2001 the degree in Biological Science with a summa cum laude from the University of Rome “La Sapienza”.

After obtained a PhD in Genetics and Molecular Biology under the supervision of Dr. Paola Ballario (University of Rome, La Sapienza, Italy), an expert in the study of epigenetics and signal transduction, Dr. Grimaldi transitioned into a postdoctoral fellowship under the mentorship of Prof. Sassone-Corsi (University of California, Irvine, USA), a leader in the field of circadian clock, metabolism and epigenetics.

In 2011 Dr. Grimaldi joined the Drug Discovery and Development (D3) department at the Istituto Italiano di Tecnologia (IIT), where he began pursuing his own line of research focused on the study of “clock-related pathologies”, and on the identification and evaluation of novel molecules with “clock modulator” activity for therapeutic applications.



All Publications
2020
Blazevits O., Bolshette N., Vecchio D., Guijarro A., Croci O., Campaner S., Grimaldi B.
MYC-associated factor max is a regulator of the circadian clock
International Journal of Molecular Sciences, vol. 21, (no. 7)
2020
Di Cristo L., Grimaldi B., Catelani T., Vazquez E., Pompa P.P., Sabella S.
Repeated exposure to aerosolized graphene oxide mediates autophagy inhibition and inflammation in a three-dimensional human airway model
Materials Today Bio, vol. 6
2019
Geven M.A., Luo H., Koo D., Panambur G., Donno R., Gennari A., Marotta R., Grimaldi B., Tirelli N.
Controlling disulfide restructuring for bioconjugation on polymer nanoparticle surfaces
Advanced Functional Polymers for Medicine
Poster Conference
2019
Geven M., Luo H., Koo D., Panambur G., Donno R., Gennari A., Marotta R., Grimaldi B., Tirelli N.
Disulfide-Mediated Bioconjugation: Disulfide Formation and Restructuring on the Surface of Nanomanufactured (Microfluidics) Nanoparticles
ACS Applied Materials and Interfaces, vol. 11, (no. 30), pp. 26607-26618
Article Journal
2018
Allavena G., Debellis D., Marotta R., Joshi C.S., Mysorekar I.U., Grimaldi B.
A broad-spectrum antibiotic, DCAP, reduces uropathogenic Escherichia coli infection and enhances vorinostat anticancer activity by modulating autophagy article
Cell Death and Disease, vol. 9, (no. 7)