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Mauro Lapelosa

Post Doc

Contacts

+39 010 71781 330

About

Ph.D. (2012) in Molecular Biophysics and Computational Biology at Rutgers University, New Brunswick (USA).

Selected Publications

Lapelosa M. Conformational dynamics and free energy of BHRF1 binding to Bim BH3. Biophysical Chemistry Nov 2017

Lapelosa M. Free energy of binding and mechanism of interaction for the MEEVD-TPR2A peptide-protein complex. J. Chem. Theory Comput., 2017, 13 (9), pp 4514–4523

Yu TQ, Lapelosa M, Vanden-Eijnden E, Abrams CF. Full kinetics of CO entry, internal diffusion, and exit in myoglobin from transition-path theory simulations. Journal of American Chemical Society 2015. 137 (8): 3041-3050.

Lapelosa M, Patapoff TW, Zarraga IE.Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye. Biophysical Chemistry. 213, 17-24, 2016

Lapelosa M, Patapoff TW, Zarraga IE.Modeling of protein-anion exchange resin interaction for the human growth hormone charge variants. Biophysical Chemistry. 2015. 207: 1-6

Lapelosa M, Patapoff TW, Zarraga IE. Molecular simulations of the pairwise interaction of monoclonal antibodies. Journal of Physical Chemistry B. 2014 118 (46): 13132-41.

Yi G,Lapelosa M, Bradley R, Mariano TM, Dietz DE, Hughes S, Wrin T, Petropoulos C, Gallicchio E, Levy RM, Arnold E, Ferstandig-Arnold G. Chimeric rhinoviruses displaying MPER epitopes elicit Anti-HIV neutralizing responses. PloS One. 2013. 8 (9): e72205.

Lapelosa M, Abrams CF. Transition-path theory calculations on non-uniform meshes in two and three dimensions using finite elements. Computer Physics Communications. 2013. 184 (10): 2310-2315.

Lapelosa M, Abrams CF. A computational study of water and CO migration sites and channels inside myoglobin. Journal of Chemical Theory and Computation 2013. 9 (2): 1265–1271.

Tan Z, Gallicchio E, Lapelosa M, Levy RM. Theory of binless multi-state free energy estimation with applications to protein-ligand binding. Journal of Chemical Physics 2012. 136 (14):144102.

Lapelosa M, Gallicchio E, Levy RM. Conformational Transitions and Convergence of Absolute Binding Free Energy Calculations. Journal of Chemical Theory and Computation 2012. 8(1):47-60.

Gallicchio E, Lapelosa M, Levy RM. Binding Energy Distribution Analysis Method (BEDAM) for Estimation of Protein−Ligand Binding Affinities. Journal of Chemical Theory and Computation 2010. 6(9):2961-2977.

Lapelosa M, Arnold GF, Gallicchio E, Arnold E, Levy RM. Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41epitopes. Journal of Molecular Biology 2010. 397(3):752-66.

Lapelosa M, Gallicchio E, Arnold GF, Arnold E, Levy RM. In silico vaccine design based on molecular simulations of rhinovirus chimeras presenting HIV-1 gp41 epitopes. Journal of Molecular Biology 2009. 385(2):675-91.

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.