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Luca Coluccino

PhD/Fellow

Former colleague

Research Line

Nanoscopy & NIC@IIT

Center

IIT Central Research Lab Genova

Contacts

Via Morego 30

About

Luca Coluccino was born in Genoa in 1987 and, after a scientific education at high school, he received the Bachelor degree in Biomedical Engineering from the University of Genoa in 2009, with a thesis on “The interplay between cells and Polymethylmethacrylate (PMMA): the surface hydrophilicity effects”. After he got the Master degree in Biomechanics and Biomaterials in 2012, discussing the thesis: “Design and development of a bioactive alginate based scaffold to induce a selective cellular differentiation”, made in collaboration with the National Research Council (CNR).

In 2012 he was Visiting Fellow at the Institute of Electronics, Computer and Telecommunication Engineering (IEIIT) of CNR.

In 2013 he joined the IEIIT department of CNR as Associate Researcher where he has been working on the design, the development and the manufacturing of electromechanical devices in order to model and validate smart biomaterial for Tissue Engineering and Regenerative Medicine applications : project under the commission “ Machine Learning, Modeling and Growing up “.

Since January 2013 he is a Ph.D. student in the Doctoral School of “Life and Humanoid Technologies” at the Italian Institute of Technology, in the Nanophysics department: his research’s attention goes to the Biomechanics of bioactive materials for Tissue Engineering applications.

In June 2014 he joined the Center for Cellular and Molecular Engineering Lab in the Department of Orthopaedic Surgery at the University of Pittsburgh as Visiting Research fellow. Actually he is working on the characterization and validation of hydrogels for osteochondral tissue engineering applications, specifically addressing the regeneration of knee meniscus cartilage; his research efforts go to the processes to optimize the scaffold cellularization and the assessment of the most effective biochemical and biomechanical stimulation regimes with different grow factors and bioreactor systems for in vitro stem cell and tissue culture.


Selected Publications

L. Coluccino, P. Stagnaro, M. Vassalli, S. Scaglione
" Bioactive TGF-beta1/HA alginate-based scaffolds for osteochondral tissue repair: design, realization and multi-level characterization".
Journal of Applied Biomaterials & Functional Materials, August 2014. (Under revision)


S. Scaglione, L. Ceseracciu, M. Aiello, L. Coluccino, F. Ferrazzo, P. Giannoni, R. Quarto
" A novel scaffold geometry for chondral applications. Theoretical model and in vivo validation".
Biotechnology and Bioengineering, 2014; 9999: 1-13.



L. Coluccino, P. Stagnaro, M. Vassalli, I. Schizzi, S. Scaglione
" Bioactive TGFbeta - CaP- alginate based scaffolds for osteochondral tissue repair: design, realization and multi-level characterization".
 TERMIS World Congress 2012. Tissue Engineering and Regenerative Medicine International Society, Vienna, (AUT), 5 – 8 September 2012.

S. Scaglione, L. Coluccino, M. Vassalli, I. Schizzi, P. Stagnaro
" Design, realization and multi-level characterization OF alginate-based scaffolds for osteochondral tissue repair".
Eupoc 2012 – Porous Polymer-Based Systems: From Design to Application. Gargnano (ITA), 3-7 June, 2012.

C. Peres, F. D’Autilia, L. Coluccino, L. Ceseracciu, P. Bianchini, A. Diaspro
"Polarization- modulated SHG characterization of collagen for meniscus regeneration".
MAF 2013 –  13th Conference on Methods and Applications ofFluorescence, Genoa (ITA), 8-11 September, 2013.

L. Coluccino
, S. Scaglione, L. Ceseracciu
" Biomechanical mapping of knee meniscus cartilage as a functional template for a Tissue Engineering application".
MIME 2013 –  Materials in Medicine, Faenza (ITA), 8-11 October, 2013.

L. Coluccino, C. Peres, P. Bianchini, A. Diaspro, F.Ayadi, A. Athanassiou, L. Ceseracciu
" Poly Vinyl Alcohol Engineered Hydrogel for a Knee Meniscus Regeneration ".
TERMIS EU 2014 –  Tissue Engineering and Regenerative Medicine International Society, European chapter meeting, 10 – 13 June 2014, Genoa (ITA).

L. Coluccino, L. Molfetta, S. Scaglione
" Application of an Advanced Bioreactor System for Cartilage Regeneration on Polyvinyl Alcohol Porous Hydrogel Scaffolds ".
TERMIS EU 2014 –  Tissue Engineering and Regenerative Medicine International Society, European chapter meeting, 10 – 13 June 2014, Genoa (ITA).

A. Marrella, L. Coluccino, R. Quarto, S. Scaglione
" A novel architectural and chemical gradient based scaffold for articular tissue regeneration".
TERMIS EU 2014 –  Tissue Engineering and Regenerative Medicine International Society, European chapter meeting, 10 – 13 June 2014, Genoa (ITA).

Farkas B., Beke S., Romano I., Coluccino L., Ceseracciu L., Brandi F.
" In situ varying the stiffness properties of excimer-laser-fabricated poly(propylene fumarate) scaffolds as a function of laser parameters".
TERMIS EU 2014 –  Tissue Engineering and Regenerative Medicine International Society, European chapter meeting, 10 – 13 June 2014, Genoa (ITA).

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.