IIT People Search

Laura Cancedda

Senior Researcher Tenured - Principal Investigator
Brain Development and Disease
Phone
Address
Research center
About


Laura Cancedda graduated in Medicinal Chemistry at the University of Genoa in 1999, with a thesis on the role of neurotrophic factors on neurotransmitter release. She received her Ph.D. in neurophysiology from Scuola Normale Superiore (Pisa, Italy) in 2003, under the supervision of Dr. Lamberto Maffei. In Pisa, she investigated the molecular and environmental basis of experience-dependent plasticity in the rat brain. In 2003, she moved to University of California at Berkeley in Dr. Poo’s laboratory where she focused her studies on molecular mechanisms of GABAergic-transmission modulation. Starting in 2006, she has also started a collaboration on a project aimed at studying early determinants of neuronal polarization.

Currently, she holds a team-leader position at the Italian Institute of Technology (IIT) in Genoa and a scientist position at the Telethon Dulbecco Institute. Laura is also a scholar of the FENS KAVLI network of excellence. Her research focuses on the role of extracellular factors such as GABA in neurogenesis, migration and morphological maturation of cortical neurons under physiological as well as pathological conditions.

Laura comes from a neurophysiological and neuropharmacological background. The techniques applied in her laboratory include, among others,in vitroelectrophysiology on brain slices and cell cultures,in vivotransfection of nucleic acids (in uteroelectroporation),in vitroandin vivopharmacology, immunohistochemistry, and confocal imaging. She also has experience in rodent behavioral testing.In addition to her technical expertise, Laura has substantial writing and editing experience.


Honors and Awards

2019    Program Committee officer member for the Federation of European Neuroscience Societies (FENS)  (proposed by Italian Society for Neuroscience).

Proposed for the IBRO-Kemali Prize 2019

2018    National habilitation as full professor of Pharmacology

National habilitation as full professor of Physiology

2017    Selected among the best 100 young Italian scientists operating in Italy or abroad (Cartaditalia magazine)

2016    Awarded the European Research Council (ERC) consolidator grant.

The project was featured in the press release (7 projects featured out of 314 funded) for announcing the results of 2016 ERC CoG by the communication unit of the ERC.

Appointed scholar of the FENS-KAVLI network of excellence. https://fenskavlinetwork.org/ 

Young researcher award, memorial Mario Mai.

2015    Appointed assistant scientist at the Dulbecco Telethon Institute, Italy

2014    National habilitation as assistant professor of Physiology.

TRADECOM society adopted Telethon Project on Rett syndrome for communication to the lay public.

2013    Mention of honor, poster award, Convention Telethon, Italy.

Finalist at the scientific picture award “Beyond science”, Genova, Italy.

2011    Best poster award, Molecular Mechanisms in Neuroscience meeting, Rome, Italy.

2009    Young investigator award, Italian Society of Physiology (SIF), Italy.

2008    Best speaker award, Italian Society for Neuroscience (SINS), Milan, Italy.

2003    Ph.D. earned with Honors, Scuola Normale Superiore, Pisa, Italy.

2001    Travel award for participation to summer course “Structure, Function and Development of the Visual System”, Cold Spring Harbor Laboratory (CSHL), U.S.A.

1999    Graduation with Honors and Distinction in Major, University of Genoa, Italy.

1997    Scholarship for extracurricular departmental activities, University of Genoa, Italy.

Education

Title: Ph.D. Neurophysiology, Neurodevelopment
Institute: Scuola Normale Superiore (Ecole Normale Superieure)
Location: Pisa
Country: Italy
From: 2000 To: 2003

Title: MSc Med. Chemistry, Neuropharmacology
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 1994 To: 1999

Experience External

Title: Assistant scientist
Institute: Dulbecco Telethon Insitute
Location: null
Country: Italy
From: 2016 To: null

Title: Post doctoral fellow (Advisor: Poo MM)
Institute: University of California
Location: Berkeley
Country: USA
From: 2003 To: 2007

Title: Graduate student (Advisor: Maffei L)
Institute: Scuola Normale Superiore
Location: Pisa
Country: Italy
From: 2000 To: 2003

Top Publications
2020
Savardi A., Borgogno M., Narducci R., La Sala G., Ortega J.A., Summa M., Armirotti A., Bertorelli R., Contestabile A., De Vivo M., Cancedda L.
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Chem, vol. 6, (no. 8), pp. 2073-2096
Article Journal
2020
Pinto B., Morelli G., Rastogi M., Savardi A., Fumagalli A., Petretto A., Bartolucci M., Varea E., Catelani T., Contestabile A., Perlini L.E., Cancedda L.
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
Neuron, vol. 108, (no. 5), pp. 887-904.e12
2019
Naskar S., Narducci R., Balzani E., Cwetsch A.W., Tucci V., Cancedda L.
The development of synaptic transmission is time-locked to early social behaviors in rats
Nature Communications, vol. 10, (no. 1)
2018
Szczurkowska J., Pischedda F., Pinto B., Manago F., Haas C.A., Summa M., Bertorelli R., Papaleo F., Schafer M.K., Piccoli G., Cancedda L.
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice
Brain, vol. 141, (no. 9), pp. 2772-2794
2014
Zuccaro E., Bergami M., Vignoli B., Bony G., Pierchala B.A., Santi S., Cancedda L., Canossa M.
Polarized Expression of p75NTR specifies axons during development and adult neurogenesis
Cell Reports, vol. 7, (no. 1), pp. 138-152
All Publications
2020
Szczurkowska J., Lee S.-I., Guo A., Cwetsch A.W., Khan T., Rao S., Walz G., Huber T.B., Cancedda L., Pautot S., Shelly M.
A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development
Cell Reports, vol. 31, (no. 2)
2020
Savardi A., Borgogno M., Narducci R., La Sala G., Ortega J.A., Summa M., Armirotti A., Bertorelli R., Contestabile A., De Vivo M., Cancedda L.
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders
Chem, vol. 6, (no. 8), pp. 2073-2096
Article Journal
2020
Trovato F., Parra R., Pracucci E., Landi S., Cozzolino O., Nardi G., Cruciani F., Pillai V., Mosti L., Cwetsch A.W., Cancedda L., Gritti L., Sala C., Verpelli C., Maset A., Lodovichi C., Ratto G.M.
Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter
Nature Communications, vol. 11, (no. 1)
Article Journal
2020
Onesto V., Villani M., Narducci R., Malara N., Imbrogno A., Allione M., Costa N., Coppede N., Zappettini A., Cannistraci C.V., Cancedda L., Amato F., Di Fabrizio E., Gentile F.
Publisher Correction: Cortical-like mini-columns of neuronal cells on zinc oxide nanowire surfaces (Scientific Reports, (2019), 9, 1, (4021), 10.1038/s41598-019-40548-z)
Scientific Reports, vol. 10, (no. 1)
2020
Pinto B., Morelli G., Rastogi M., Savardi A., Fumagalli A., Petretto A., Bartolucci M., Varea E., Catelani T., Contestabile A., Perlini L.E., Cancedda L.
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
Neuron, vol. 108, (no. 5), pp. 887-904.e12
Award Achievement
2016
Cancedda L.
Appointed scholar of the FENS-KAVLI network of excellence.
2016
Cancedda L.
European Research Council (ERC) consolidator grant. The project was featured in the press release (7 projects featured out of 314 funded) for announcing the results of 2016 ERC CoG by the communication unit of the ERC.
2015
Cancedda L.
Appointed assistant scientist at the Dulbecco Telethon Institute, Italy