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Iris Tanaka

Post Doc
Genomic Science
Research center
About

I am a molecular biologist and I have completed my scientific training in Japan, France, and the UK. I have a desire to understand the molecular mechanisms of cancer biology, especially breast cancer biology. I am also fascinated by RNA biology, and how it impacts cellular behaviour in complex ways.

Current Project : Epitranscriptional dynamics of MYC-driven genes

The MYC transcription factor is a key player in oncogenic transcription programs. So far, the study of MYC-driven gene expression programs neglected that RNA abundance and its variation are determined by the kinetic rates of three steps, which collectively shape the dynamics of the RNA life cycle: RNA synthesis, processing, and degradation.

Recently, the lab pioneered the development of novel methods to study RNA dynamics, based on RNA metabolic labeling and mathematical modeling and showed that the acute modulation of MYC has broad consequences on all stages of the RNA and life cycle.

The fate of thousands of mRNAs in eukaryotic cells is markedly influenced by the presence of multiple epitranscriptional modifications, the most abundant being the N6-methyladenosine (m6A). While it has been recently shown that the m6A machinery interacts with the epigenome and the transcriptional machinery, it is currently unclear if the m6A epitranscriptome is important for the establishment of gene expression programs driven by specific transcription factors such as MYC.

I am particularly interested in studying the interplay between the m6A machinery and the dynamics of MYC-driven genes in breast cancer. Indeed, MYC amplification is associated with high-grade tumours and triple-negative breast cancer. The epitranscriptome is also heavily altered in those breast cancer types. Understanding the relationship between the methylation and the life-cycle of specific transcripts could shed light on unsuspected molecular mechanisms in these hard to treat breast cancer subtypes.

Education

Title: PhD in cancer biology
Institute: Université Paris-Saclay
Location: Orsay
Country: France
From: 2014 To: 2019

Title: Master of Sciences
Institute: Université Pierre et Marie Curie
Location: Paris
Country: France
From: 2012 To: 2014

Title: Bachelor of Engineering
Institute: Keio University
Location: Yagami
Country: Japan
From: 2008 To: 2012

Experience External

Title: PhD student
Institute: Institut Curie
Location: Orsay
Country: France
From: 2014 To: 2019

Title: Master research intern
Institute: Manchester University, Cancer Research UK Manchester Institute
Location: Manchester
Country: United Kingdom
From: 2014 To: 2014

Title: Master research intern
Institute: Université Pierre et Marie Curie
Location: Paris
Country: France
From: 2013 To: 2013

Title: Bachelor student
Institute: Keio University
Location: Yagami
Country: Japan
From: 2011 To: 2012

All Publications
2020
Furlan M., Tanaka I., Leonardi T., de Pretis S., Pelizzola M.
Direct RNA Sequencing for the Study of Synthesis, Processing, and Degradation of Modified Transcripts
Frontiers in Genetics, vol. 11
2020
Tanaka I., Chakraborty A., Saulnier O., Benoit-Pilven C., Vacher S., Labiod D., Lam E.W.F., Bieche I., Delattre O., Pouzoulet F., Auboeuf D., Vagner S., Dutertre M.
ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin
Nucleic Acids Research, vol. 48, (no. 5), pp. 2676-2693