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Francesca Succol


Research Line

Optical Approaches to Brain Function


IIT Central Research Labs Genova


Via Morego,30
+39 010 2896 782
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Francesca Succol graduated in Biology at the University of Padova in 2004 studying muscle protein interactions by using luminescence oxygen channeling immunoassay (LOCI) technique. After the degree in Biology she spent 6 months working in the Prof. G. Valle Lab in the Department of Biology, Padova where she went on to study protein-protein interaction in the muscle. In the 2004 she got the Italian Qualification Test for Biologist profession. In 2005 she moved to the Department of Pharmacology, University of Pennsylvania, Philadelphia, in Prof. D. Praticò Lab, as graduate student, where she studied from 3/2005 to 6/2007 the Role of 12/15 lipoxygenase in Alzheimer’s disease pathogenesis. From 7/2007 to 2/2008 she moved to the Department of Neuroscience, University of Pennsylvania School of Medicine in Prof. SJ Moss, where she studied the Molecular determinant and trafficking of g-aminobutyric acid (GABA) receptors on the neuronal surface. In 2008 she moved to the Italian Institute of Technology (IIT) as a Junior Technician, Supervisor of the Cell Culture Facility in the Department of Neuroscience and Brain Technology. From 1/2009 to 4/2012 she followed the PhD program in Technological and Biomedical Sciences, University of Genoa. During her PhD she investigated the Role of Intracellular Chloride concentration in the GABAA Receptor subunit composition, working in the Dott. A. Barberis Lab in IIT. She has strong experience in cellular and molecular biology, biochemical and electrophysiology techniques.


Selected Publications

- Francesca Succol, Domenico Pratico’. A role for 12/15 Lipoxygenase in the Amyloid b Precursor Protein metabolism J. Neurochem. 2007 Oct; 103(1):380-7.  


- Tija Jacob, Qin Wan, Mansi Vithlani, Richard Saliba, Francesca Succol, Menelas Pangalos, Stephen Moss. GABAA receptor membrane trafficking regulates spine maturity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12500-5. Epub 2009 Jul 14. July.


- Tommaso Fellin, Michael M. Halassa, Miho Terunuma, Francesca Succol, Hajime Takano, Stephen J Moss and Philip G. Haydon. Endogenous non neuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15037-42. Epub 2009 Aug 17.



- Petrini EM, Thierry Nieus, Ravasenga T, Succol F, Guazzi S, Benfenati F, Barberis A. Influence of monoliganded states of GABAA R on GABAergic responses. J Neurosci. 2011 Feb 2;31(5):1752-61.


- Succol F., Fiumelli H, Benfenati F, Cancedda L and Barberis A. Intracellular chloride concentration influences the GABAA receptor subunit composition. Nat Commun. 2012 Mar 13;3:738.

- Jacob TC, Michels G, Silayeva L, Haydon J, Succol F, Moss SJ. Benzodiazepine treatment induces subtype-specific changes in GABAA receptor trafficking and decreases synaptic inhibition. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18595-600.


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