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Francesca Manago

Post Doc

Research Line

Genetics of Cognition

Center

IIT Central Research Labs Genova

Contacts

Via Morego 30
+39 010 2896 857
Contact Me

About

Jenuary 2012 - present: Post Doc at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Francesco Papaleo

January 2011 - December 2011: research fellowship at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

January 2008 - December 2010: Ph.D. student at the University of Genoa-Italian Institute of Technologies. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

November 2008 - May 2009: visiting graduate student at the Gastroenterology Department, Duke University, Durham NC, USA. Supervisor: Dr. Richard Premont.

May 2005 - December 2007: experimental research in the Laboratory of Psychobiology, Department of Genetic and Molecular Biology, University of Rome “La Sapienza” , Rome, Italy. Supervisors: Prof. Andrea Mele and Prof. Alberto Oliverio.

October 2006:               visiting student at "Laboratoire de Neurobiologie Cellulaire et Fonctionnelle”, Centre National de la Recherche Scientifique, Marseille, France. Supervisor: Dr. Marianne Amalric.

Projects

 

Multiple genes interactions in brain development and cognitive alterations related to Schizophrenia

She is investigating genetic mutations as a potential cause/mechanism for the development of cognitive and schizophrenia-related abnormalities.  In more details, her project will dissect the role of interactions between multiple schizophrenia-susceptibility genes in brain development and prefrontal cortex (PFC)-dependent cognitive functions. This will be attained using a new in utero electroporation technique recently developed at the IIT able to knocking down concomitantly two or more genes specifically in the PFC.

Selected Publications

De Leonibus E., Managò F., Giordani F., Petrosino F., Lopez S., Oliverio A., Amalric M., Mele A. Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson disease. Neuropsychopharmacology. 2009 Feb;34(3):729-38

Managò F., Castellano C., Oliverio A., Mele A. and De Leonibus E. Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task. Learn Mem. 2008 Dec 30;16(1):46-52. Print 2009 Jan

 

Managò F., Espinoza S., Salahpour A., Sotnikova T.D., Caron M.G. Premont R.T., and Gainetdinov R.R. The role of GRK6 in animal models of Parkinson’s Disease and L-DOPA treatment. Sci Rep. 2012;2:301. Epub 2012 Mar 5.

 

Espinoza S., Managò F., Leo D., Sotnikova T.D.,  and Gainetdinov R.R. Role of Catechol-O-Methyltransferase (COMT)-dependent processes in Parkinson’s Disease and L-DOPA treatment. CNS & Neurological Disorders-drug Targets.

Awards

Travel awards:

SINS fellowship for young Italian neuroscientists to attend the 8th IBRO World Congress of Neuroscience (in Florence, 2011).

 

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