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Francesca Manago

Post Doc

Research Line

Genetics of Cognition

Center

IIT Central Research Labs Genova

Contacts

Via Morego 30
+39 010 71781 857
Contact Me

About

Jenuary 2012 - present: Post Doc at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Francesco Papaleo

January 2011 - December 2011: research fellowship at the Neuroscience and Brain Technologies Department, Italian Institute of Technologies, Genoa, Italy. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

January 2008 - December 2010: Ph.D. student at the University of Genoa-Italian Institute of Technologies. Supervisor: Dr. Raul R Gainetdinov. Director: Prof. Fabio Benfenati.

November 2008 - May 2009: visiting graduate student at the Gastroenterology Department, Duke University, Durham NC, USA. Supervisor: Dr. Richard Premont.

May 2005 - December 2007: experimental research in the Laboratory of Psychobiology, Department of Genetic and Molecular Biology, University of Rome “La Sapienza” , Rome, Italy. Supervisors: Prof. Andrea Mele and Prof. Alberto Oliverio.

October 2006:               visiting student at "Laboratoire de Neurobiologie Cellulaire et Fonctionnelle”, Centre National de la Recherche Scientifique, Marseille, France. Supervisor: Dr. Marianne Amalric.

Projects

 

Multiple genes interactions in brain development and cognitive alterations related to Schizophrenia

She is investigating genetic mutations as a potential cause/mechanism for the development of cognitive and schizophrenia-related abnormalities.  In more details, her project will dissect the role of interactions between multiple schizophrenia-susceptibility genes in brain development and prefrontal cortex (PFC)-dependent cognitive functions. This will be attained using a new in utero electroporation technique recently developed at the IIT able to knocking down concomitantly two or more genes specifically in the PFC.

Selected Publications

De Leonibus E., Managò F., Giordani F., Petrosino F., Lopez S., Oliverio A., Amalric M., Mele A. Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson disease. Neuropsychopharmacology. 2009 Feb;34(3):729-38

Managò F., Castellano C., Oliverio A., Mele A. and De Leonibus E. Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task. Learn Mem. 2008 Dec 30;16(1):46-52. Print 2009 Jan

 

Managò F., Espinoza S., Salahpour A., Sotnikova T.D., Caron M.G. Premont R.T., and Gainetdinov R.R. The role of GRK6 in animal models of Parkinson’s Disease and L-DOPA treatment. Sci Rep. 2012;2:301. Epub 2012 Mar 5.

 

Espinoza S., Managò F., Leo D., Sotnikova T.D.,  and Gainetdinov R.R. Role of Catechol-O-Methyltransferase (COMT)-dependent processes in Parkinson’s Disease and L-DOPA treatment. CNS & Neurological Disorders-drug Targets.

Awards

Travel awards:

SINS fellowship for young Italian neuroscientists to attend the 8th IBRO World Congress of Neuroscience (in Florence, 2011).

 

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I numeri di IIT

L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.