Education: Degree in Molecular and Cellular Biology at University of Milano (Italy). PhD in Neurobiology at University of Varese (Italy).
Working experience: 1999-2003 Research Fellow at DIBIT, Vita-Salute San Raffaele Institute, Milano (Italy). Where he worked on post-transcriptional control of gene expression, in particular he investigated a tissue-specific Internal Ribosome Entry Site (IRES) and BACE1 mRNA (encoding the ß-secretase protein involved in Alzheimer’s disease) translation, in normal and pathological conditions. 2004 to 2008 Post-doctoral fellow in the laboratory of Wieland Huttner at Max-Planck Institute of Molecular Cell-Biology and Genetics, Dresden (Germany). Where he started a project on microRNAs in the control of mouse neurogenesis and neocortical development. He also developed a Dual Fluorescence Reporter/Sensor (DFRS) plasmid for the acute in vivo detection of miRNAs expression at the single-cell level, and collaborated with Clontech inc. (Mountain View, CA, USA) for the application of DFRS plasmid to biotechnology. 2008 Team leader (without budget independence) at the Neuroscience and Brain Tech dept. of the Italian Institute of Technology. Since 11/2013 Tenure Track Senior researcher, PI of the Neurobiology of miRNAs lab. same institute.
Membership of Professional Societies:
2008 – Present Full Member, RNA Society https://www.rnasociety.org/
2010 – Present Full Member, International Society for Stem Cells Research http://www.isscr.org/
2015 – Present Associate Member, Japan Neuroscience Society http://www.jnss.org/en/
Regular Reviewer for the Journals (listed in alphabetical order): Biol Psych; Brain Plast; Cell Mol Life Sci; Development; Develop Biol; EMBO Rep; Front Neurosci; Genes Brain Behav; Hum Mol Gen; Int J Dev Neurosci; J Mol Neurosci; J Neurosci; Mol. Psych; Nature Comm; Neurogenesis; Neuron; Nucl Acids Res; Prog Neurob; RNA Biol; RNA; Sci Rep; Stem Cells Dev; Stem Cell Rep; Trend. Biotech.
Grant reviewer: 2011 Singapore Medical Research Council, SG; 2015 Swiss National Research Foundation, CH; 2017 Wellcome-Trust, UK
Since 2013 – Editorial board member, Frontiers in Molecular Neuroscience
2017 Symposium co-organizer “Emerging complexity and functions of miRNAs-dependent regulation in neuroscience”; German Neuroscience Society meeting. Göttingen, Germany. www.nwg-goettingen.de/2017
2017 External Member of the PhD evaluation committee, Amsterdam Univ, The Netherlands
Collaboration with Techniplast SPA (Italy)
Former Lab Members:
01/2008 – 03/2012 Yoanne M. Clovis (PhD Student).
01/2012 – 12/2014 Emanuela de Luca (PhD Student).
01/2012 –02/2015 Federica Marinaro (PhD Student).
01/2012 – 03/2015 Alessandro Simi (Cotutored PhD Student).
09/2011 – 05/2013 Francesco Niola, PhD (Senior Postdoc, Marie Curie Fellow).
05/2014 – 09/2015 Philipp Follert, PhD (Postdoc).
2013 – 2017 Meritxell Pons-Espinal, PhD (Postdoc).
-Process and device for the determination of alterations in neuronal connectivity and/or morphology; 2015-02-19 | patent PAT: US 20150051109 A1
-Composizione farmaceutica di miRNA e suoi usi terapeutici. Depositato all’ufficio brevetti Italiano Sept.,19th 2016. Rif IIT PT160330; n. 102016000093825
EU-REA, Marie Curie Actions (MCA) Call: FP7-PEOPLE-2010-RG. TITLE: NEUROGENESIS IN 22Q11.2 DELETION SYNDROME: ROLE OF microRNAs. ACRONYM: MIRNAS/22Q11DS. D. De Pietri Tonelli, Coordinator; F. Niola, Grantee. Project Budget, 100.000 Euros. Project duration 2011-2015.
FP7-PEOPLE-2013-IEF. Acronym: “ASTROCLOCK”; Title “Astrocyte regulation of circadian behaviour” Olga Barca Mayo (Grantee); Davide De Pietri Tonelli (Scientific Coordinator). Project Budget: 241.567 €; Project Duration: 2014 – 2016.
AIRC - Associazione Italiana per la Ricerca sul Cancro. Title: Stimuli-Responsive Nanoparticles for eradicating different subsets of cancer cells within tumors. PI Teresa Pellegrino; Davide De Pietri Tonelli (Collaborator). Project Budget 180.000 €; Project Duration 02/01/2014-01/01/2017.
Fondazione CARIPLO, Call 2015 “Biomedical research on ageing-related diseases”. Title “Role of the astrocyte-mediated circadian clock in neurodegeneration and brain aging”. PI/Coordinator Francesco Nicassio IIT@SEMM, Milan; Co-PIs: Davide De Pietri Tonelli, Olga Barca Mayo (NBT Dept. IIT Genoa) and Michele Cilli (H San Martino, Genoa). Project Budget 349,650 €. Project duration 2016-2020
AIRC - Investigator Grant. Role PI. Title: Differentiation therapy for GBM through synergic action of 11 miRNAs/drugs delivered via lipid/polymeric nanoparticles. Project Budget 599.610 €. Project Duration 2018-2022