Dr. Christos Tapeinos received his bachelor degree in Material Science from the University of Patras in 2006. He got his MSc (2009) and his PhD. (2013) from the same university in Material Science in collaboration with the National Centre for Scientific Research “Demokritos” in the area of stimuli-responsive drug delivery systems. From 2015 to 2017 he worked at the National University of Ireland Galway as a Marie Curie postdoctoral research fellow and he was part of the Centre for Research in Medical Devices (CÚRAM) under the supervision of Prof. Abhay Pandit. Dr. Tapeinos was also a visiting Researcher at the University of Chicago from October 2016 to January 2017 where he collaborated with Prof. J. Hubbell's group, studying the differentiation of human monocytes under oxidative stress and under treatment with collagen nanospheres.
His research interest is focused on delivery systems that respond to various stimuli, including pH, temperature, alternating magnetic field and reactive oxygen species (ROS). In addition, Dr. Tapeinos has fabricated a variety of biomaterial-based structures, including nanospheres, microspheres and fibers using natural (collagen & hyaluronic acid) and/or synthetic polymers (PMMA,PAA,PHPMA,PLGA) for the treatment of various diseases, like Intervertebral Disc Degeneration, Myocardial Infarction and Cancer (breast, prostate and multiple myeloma). Moreover, he was involved in the synthesis and characterization of inorganic nanoparticles including MnO2, CeO2, CuO, ZnO etc. Dr. Tapeinos studies also the biological interactions of the synthesized materials in live cells and tissues.
Currently, Dr. Tapeinos works as a postdoctoral researcher at the Italian Institute of Technology at the Smart Bio-Interfaces group under the supervision of Prof. Gianni Ciofani, where he focuses his research on the fabrication of Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for the treatment of Glioblastoma Multiforme.
Christos Tapeinos, Matteo Battaglini, Gianni Ciofani, Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases. Journal of Controlled Release (7.786) (Accepted Manuscript), doi: 10.1016/j.jconrel.2017.08.033
Joëlle Bizeau, Christos Tapeinos, Abhay Pandit, Synthesis and characterization of hyaluronic acid-coated manganese dioxide microparticles that act as ROS scavengers. Colloids & Surfaces B: Biointerfaces (3.902) (Accepted Manuscript) (shared authorship)
Christos Tapeinos, Aitor Larrañaga, Jose-Ramon Sarasua, Abhay Pandit, Functionalised collagen spheres reduce H2O2 mediated apoptosis by scavenging overexpressed ROS. Nanomedicine: Nanotechnology, Biology and Medicine (5.671), DOI:10.1016/j.nano.2017.03.022
Christos Tapeinos, Eleni K. Efthimiadou, Nikos Boukos, George Kordas, Sustained release profile of quatro stimuli nanocontainers as a multi sensitive vehicle exploiting cancer characteristics. Colloids and Surfaces B: Biointerfaces (3.902), DOI: 10.1016/j.colsurfb.2016.08.019
Christos Tapeinos and Abhay Pandit, Physical, chemical and biological structures based on ROS-sensitive moieties that are able to respond to oxidative microenvironments. Advanced Materials, 28, 5553–5585 (2016) (18.960), DOI: 10.1002/adma.201505376
Hongliang Cao, Yixiao Dong, Ligia Bre, Christos Tapeinos, Wenxin Wang and Abhay Pandit, An acetal-based polymeric crosslinker with controlled pH-sensitivity. RSC Advances (3.289), 2016, 6, 9604-9611. DOI: 10.1039/C6RA00423G
Efthimiadou E.K., Tapeinos C., Tziveleka L.-A., Boukos N., S, pH- and thermo-responsive microcontainers as potential drug delivery systems: Morphological characteristic, release and cytotoxicity studies. Materials Science and Engineering C (3.420) 37 (1), 271-277 (2014). DOI: 0.1016/j.msec.2014.01.024
Efthimiadou E.K., Tapeinos C., Chatzipavlidis A, Boukos N, Fragogeorgi E , Palamaris L, Loudos G., Kordas, G, Dynamic in vivo imaging of dual-triggered microspheres for sustained release applications: Synthesis, characterization and cytotoxicity study. International Journal of Pharmaceutics (3.65), 461 (1-2), 54-63 (2014). DOI: 10.1016/j.ijpharm.2013.11.037
Tapeinos C., Efthimiadou E. K., Boukos N., Charitidis C. A., Koklioti M., & Kordas G. Microspheres as therapeutic delivery agents: synthesis and biological evaluation of pH responsiveness. Journal of Materials Chemistry B (4.872), 1(2), 194 (2013). DOI: 10.1039/c2tb00013j
Kordas G., Tziveleka L., Efthimiadou E., Bilalis P., Chatzipavlidis A., Tapeinos C., Metaxa A.F., Pappas G. Tailoring nanostructured polymer containers for multi stimuli activated drug controlled release, Wound Repair and Regeneration 20(5):A99-A99 (2012). DOI: 10.1111/j.1524-475X.2012.00834.x
Efthimiadou E. K., Tapeinos C., Bilalis P., & Kordas G., New approach in synthesis, characterization and release study of pH-sensitive polymeric micelles, based on PLA-Lys-b-PEGm, conjugated with doxorubicin. Journal of Nanoparticle Research (2.101), 13(12), 6725–6736 (2011). DOI: 10.1007/s11051-011-0579-5
Efthimiadou E. K., Bilalis P., Kordas G, Chatzipavlidis A. and Tapeinos C. Smart Nanoparticles as new Drug Delivery Systems: Bioapplications. Planta Med 2011; 77 - PK19, DOI: 10.1055/s-0031-1282649
Tapeinos C., Kartsonakis I., Liatsi P, Daniilidis I, Kordas G, Synthesis and characterization of magnetic nanocontainers Journal of the American Ceramic Society (2.428), 91(4), 1052-1056 (2008). DOI: 10.1111/j.1551-2916.2007.02240.x