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Attilio Marino Write a Message

Post Doc Fellow
Post-doctoral fellow (Fondazione Umberto Veronesi granted)

Research Line

Smart Bio-Interfaces

Center

CMBR@SSSA Pisa

Contacts

Pontedera, Viale rinaldo Piaggio 34

About

Personal information:

First name: Attilio

Surname: Marino

Birth date October 11th, 1987

Nationality: Italian

Address: Istituto Italiano di Tecnologia, Smart Bio-Interfaces. Viale Rinaldo Piaggio 34, 56025 Pontedera (PI), Italy

e-mail: attilio.marino@iit.it

Telephone +39 050883089; +39 3281211056

 

Attilio Marino received his Bachelor Degree in Ecology and Biodiversity, Neuroethologic Curriculum, with 110/110 summa cum laude and than the Master Degree in Medical Biology; grade 110/110 summa cum laude. In October 2016 he received his doctorate in Biorobotics (Scuola Superiore Sant'Anna, SSSA), grade 100/100 summa cum laude, at the Italian Institute of Technology (IIT), Center for Micro-BioRobotics @SSSA with the project: “Nanoparticles and nanostructured surfaces as smart solutions for the modulation of cellular functions”. During doctorate, he spent six months as a visiting Ph.D. student at the Waseda Bioscience Research Institute in Singapore (Wabios). Dr. Marino was currently sponsored by Fondazione Umberto Veronesi to Post-Doctoral Fellowship at the Italian Institute of Technology (IIT), Smart Bio-Interfaces group.

His main research interests are in the fields of nanomaterials for biomedical applications (e.g. remote cell stimulation mediated by piezoelectric nanoparticles, superparamagnetic nanostructures and NIR-absorbing nanomaterials), 3D nanostructured scaffolds for tissue engineering, bio-hybrid systems for the modelling of blood-brain barrier and biology in altered gravity conditions.

Dr. Marino is author or co-author of 27 ISI papers, 2 papers on international peer-reviewed non-impacted journals, 1 book chapter, 10 proceedings and 16 abstracts/posters at national/international conferences. He serves as Reviewer for more than 20 international journals and was recently selected as reviewer for the evaluation of a ERC project. He serves as Review Editor for 2 international journals (Frontiers in Molecular Biosciences and Frontiers Bioengineering and Biotechnology). He delivered 4 talks and 1 invited talk at international conferences; Dr. Marino served as chairman at the 5th International Conference on Multifunctional, Hybrid and Nanomaterials (2017). For his research activity, he was awarded with several national and international prizes. Attilio Marino held seminars at the Polytechnic University of Turin within the course of “Bionanotechnologies” (aa.yy. 2015/2016, 2016/2017, coordinated by prof. Gianni Ciofani) and at the University of Pisa "Neuroscience Methods" (2012/2013, 2013/2014, 2014/2015, coordinated by prof. Mario Pellegrino). He is currently supervisor of one M.Sc. student.

Education and training:

February 2017 – present: - Post-Doctoral Fellowship, granted by Fondazione Umberto Veronesi, at IIT (Smart Bio-Interfaces group).

October 2016 – January 2017: - Post-Doctoral Fellowship granted by Agenzia Spaziale Italiana (ASI), at IIT (Center for Micro-BioRobotics @SSSA).

October 2016: - PhD in Biorobotics; grade 100/100 summa cum laude

November 2012 – October 2016: - Ph.D. student in Biorobotics (Center for Micro-BioRobotics @SSSA). Title of the research project: “Nanoparticles and nanostructured surfaces as smart solutions for the modulation of cellular functions”. Six months period abroad at the Waseda Bioscience Research Institute in Singapore (WABIOS) in collaboration with prof. Madoka Suzuki and dr. Satoshi Arai.

May 2012: - B.Sc. in Ecology and Biodiversity (Curriculum in Neuroethology), at University of Pisa (Italy); grade 110/110 summa cum laude

April 2011 – April 2012: - Master thesis internship at the Department of Biology, Unit of Cellular Biology, University of Pisa, in collaboration with the Unit of Physiology, University of Pisa. Thesis of the Master's Degree: "Characterization of knockin line mouse embryonic stem cells Tph2eGFP: an in vitro model to study the differentiation of serotonergic neurons.

December 2009: - B.Sc. in Ecology and Biodiversity (Curriculum in Neuroethology), at University of Pisa (Italy); grade 110/110 summa cum laude

October 2008 – October 2009: - Bachelor's Thesis internship at the Department of Biology, Unit of Cellular Biology, University of Pisa. Thesis of Degree "in vitro differentiation of serotonergic neurons from embryonic stem cells Tph2eGFP

 

 

Language skills:

Mother tongue: Italian. English: understanding C2, speaking C1, writing C2. French: understanding C1, speaking C1, writing C1.

Technical skills:

Cellular biology: Electroporation of embryonic stem cells (ESCs). In vitro culture of ESCs, human mesenchymal stem cells (hMSCs), primary neurons, astrocytes, cardiomyocytes, cancer cells (neuroblastoma, glioblastoma, HeLA, SKBR3, SaOS-2,) and other cell lines (C2C12, RAW, BeND.3).

Molecular biology: Immunocytochemistry and immunohistochemistry. Handling of DNA: use of restriction enzymes, cloning, sequencing of DNA, extraction of genomic DNA and plasmid. Use of quantitative reverse transcription polymerase chain reaction (qRT-PCR). ELISA assay. Flow cytometry.

Cellular physiology: Calcium, sodium, voltage and temperature imaging on living cells. Study of cell up-take pathways through the use of different cell trackers: staining of plasma membranes, endoplasmic reticulum, early endosomes, late endosomes / lysosomes, mitochondria and Golgi apparatus on living cells. Viability assays (e.g. WST-1, Pico green, calcein/propidium iodide). Evaluation of the activity of different enzymes (e.g. superoxide dismutase and catalase).

Microscopy: Optical and fluorescence microscopy (expert user). Confocal Microscopy (expert user). Time-lapse microscopy (expert user). Scanning Electron Microscopy (SEM). Scanning probe microscopy (basic skills in scanning ion conductance microscopy, and atomic force microscopy).

Nanofabrication: Functionalization of nanomaterials with specific antibodies for promoting their crossing through the blood-brain barrier and their targeting towards cancer cells. Characterization of nanomaterials through dynamic light scattering (DLS), spectrophotometer and spectrofluorimeter. Design and polymerization of 2D/3D nanostructured scaffolds through the “two-photon polymerization” (2pp) technique. Fabrication of 3D nanostructured microfluidic systems for the generation of bio-hybrids blood-brain barriers through 2pp. Preparation of 2D-3D nanostructured scaffolds characterized by different properties (e.g. biocompatible, biodegradable, fluorescent, magnetic, piezoelectric, photo-thermic) and specific topographies (e.g. biomimetic and fractal) for the stimulation of specific cell behaviour.

Cell stimulation: Wireless cell stimulation mediated by piezoelectric nanoparticles, NIR-absorbing nanoparticles and superparamagnetic nanoparticles.

Other expertise: Experiments in altered gravity conditions through the Large Diameter Centrifuge (LDC) and on International Space Station (ISS).

Bioinformatics and software: Operating System: Macintosh, Windows, Linux. Programming languages: R (certified by “Progetto obiettivo, ambiente open source R”, June 2011). Applications: word processors, spreadsheets (e.g., Origin, Excel), analysis of AA and DNA sequences (e.g., CodonCode Aligner, Serial-Cloner), image analysis and image editing (e.g., ImageJ, NIS), statistical analysis (e.g., R, Excel, Kaleidagraph), design of nanostructured 3D scaffolds (SketchUp, Meshlab, Nanoslicer, Describe, Nanowrite).

Research topics:

Nanomaterials for applications in biomedicine: Piezoelectric remote stimulation driven by ultrasounds. Wireless cell stimulation mediated by NIR-absorbing nanomaterials. Remote stimulation assisted by superparamagnetic nanoparticles and driven by alternated magnetic fields for hyperthermia and photothermal ablation. Self-regenerative antioxidant nanoparticles for biomedical applications. Assessment of the ability of nanomaterials to cross blood-brain barrier.

Nanostructured surfaces/scaffolds: Topographical cues for the control of cell behaviour (osteogenic and neural differentiation, guidance and promotion of the axonal outgrowth). Nanocomposite 3D scaffolds for cell stimulation. 3D microfluidic models of the blood-brain barrier. Biomechanical investigations of the force exerted by cells.

Extreme biology: altered gravity conditions: Nanotechnology solutions against oxidative stress in muscle tissue during long-term microgravity exposure: experiment on international space station (ISS). Hypergravity effects on the production of reactive oxigen species in vivo models. Hypergravity-mediated nanoparticle up-take, hypergravity-mediated transfection and hypergravity-induced osteogenesis.Invited talk at international conferences

Marino, A., Ciofani G. Nanostructured Smart Materials for the Remote Manipulation of Cell Behavior. The 55th Annual Meeting of The Biophysical Society of Japan. Kumamoto, Japan. (2017)

Invited talk at international conferences

Marino, A., Ciofani G. Nanostructured Smart Materials for the Remote Manipulation of Cell Behavior. The 55th Annual Meeting of The Biophysical Society of Japan. Kumamoto, Japan. (2017)

Talk at international conferences

Marino, A. Tricinci O., Battaglini M., Mattoli V., Sinibaldi E., Ciofani G. A 3D biomimetic model of the blood-brain barrier fabricated with a two-photon lithography approach. Proc. 29th European Conference on Biomaterials. 232 (2017)

Marino A., Tonda-Turo C., de Pasquale D.,1 Ruini F., Genchi G. G., Ciardelli G., Ciofani G. Nanoceria-doped gelatin nanofibers for neuronal regeneration. 5th International Conference on Multifunctional, Hybrid and Nanomaterials. 39 (2017)

Marino A., Arai S., Hou Y., Suzuki M., Ciofani G. Gold nanoshell-assisted wireless activation of myotube contraction. International Conference on Nanomedicine and Nanobiotechnology, OS3-101-3 (2016)

Marino A., Rocca A., Rocca V., Moscato M., de Vito G., Piazza V., Mazzolai B., Mattoli V., Ngo-Anh J.T., Ciofani G. Hypergravity enhances nanoparticle up-take by stem cells: implications in biomedicine. Proc. 65th International Astronautical Conference, 269-272 (2014)

Review activities:

- Reviewer selected for the evaluation of a ERC project

- Manuscript reviewer for more than 20 ISI journals, including ACS Applied Materials & Interfaces, Acta biomaterialia, International Journal of Nanomedicine and Biomaterials Science.

- Review Editor for Frontiers in Molecular Biosciences, Bioengineering and Biotechnology and Materials

Special courses attended:

-EMBO Workshop on Stem Cell mechanobiology in development and disease. Capri (Italy). 18-21 October 2015

- Nanoscribe's User Meeting Europe (3D mesoscale printing, high resolution printing, 2D mask lithography and lab sessions). Karlsruhe Institute of Technology. Eggenstein-Leopoldshafen (Germany). 05-08 October 2015

- The toolbox for investigating the function of neural circuits at the CSNII School on Neurotechniques; Padua (Italy), 10-14 March 2014

- Nanomechanics of biomolecular adhesion at the XVIII School of Pure and Applied Biophysics; Venice (Italy), 27-31 January 2014

Teaching experience:

- Seminars at the Polytechnic University of Turin (aa.yy. 2015/2016, 2016/2017) within the course “Bionanotechnologies” (prof. Gianni Ciofani, course in Biomedical Engineering)

- Seminars at the University of Pisa (aa.yy. 2012/2013, 2013/2014, 2014/2015) within the course "Neuroscience Methods" (prof. Mario Pellegrino, M.Sc. course in Medical Biology: Neurobiology)

- Invited seminar at the European Space Agency (Redu, Belgium, 2017) in the framework of the ESA-ELGRA Gravity-Related Research Summer School 2017

Interests

His main research interests are in the fields of nanomaterials for biomedical applications (e.g. remote cell stimulation mediated by piezoelectric nanoparticles and NIR-absorbing nanoparticles) 3D scaffolds for tissue engineering and biology in altered gravity conditions.

Projects

Attilio Marino worked in the framework of the following projects:

- Piezoelectric nanoparticle-mediated inhibition of cell proliferation: molecular mechanisms in breast cancer and therapeutic implications (January 2017 - Present)

- Nanotechnology solutions against oxidative stress in muscle tissue during long-term microgravity exposure (February 2016 - January 2017)

- Nanostructured scaffolds bioinspired to vegetal ultrastructures for cell cultures (November 2015 – January 2016)

Selected Publications

Publications on ISI journals

Marino A., Tricinci O., Battaglini M., Filippeschi C., Mattoli V., Sinibaldi E., Ciofani G. A 3D real-scale, biomimetic and biohybrid model of the blood-brain barrier fabricated through two-photon lithography Small (2017) In press. doi:10.1002/smll.201702959

Rojas Cifuentes C.A., Tedesco M., Massobrio P., Marino A., Ciofani G., Martinoia S., Raiteri R. Acoustic stimulation can induce a selective neural network response mediated by piezoelectric nanoparticles. Journal of Neural Engineering. (2017) In press. doi: 10.1088/1741-2552/aaa140

Degl’Innocenti A., Rossi L., Salvetti A., Marino A., Meloni G., Mazzolai B. Ciofani G. Chlorophyll derivatives enhance invertebrate red-light and ultraviolet phototaxis. Scientific Report. 7(1): 3374 (2017)

Bonisoli A, Marino A., Ciofani G., Greco F. Topographical and Electrical Stimulation of Neuronal Cells through Microwrinkled Conducting Polymer Biointerfaces. Macromolecular Bioscience. 17(11): 1700128 (2017)

Genchi G. G., Sinibaldi E., Ceseracciu L., Labardi M., Marino A., Marras S., De Simoni G., Mattoli V., Ciofani G. Ultrasound-activated piezoelectric P(VDF-TrFE) / boron nitride nanotube composite films promote differentiation of human SaOS-2 osteoblast-like cells. Nanomedicine: Nanotechnology, Biology and Medicine. (2017) In press. https://doi.org/10.1016/j.nano.2017.05.006

Marino A., Genchi G.G., Sinibaldi E., Ciofani G. Piezoelectric Effects of Materials on Bio-Interfaces. ACS Applied Materials and Interfaces. 9(21): 17663–17680 (2017)

Genchi G.G., Marino A., Grillone A., Pezzini I., Ciofani G. Remote control of cellular functions: the role of smart nanomaterials in the medicine of the future. Advanced Healthcare Materials. 6(9): ar. n. 1700002 (2017)

Marino A., Arai S., Hou Y., Degl'Innocenti A., Cappello V., Mazzolai B., Chang Y.T., Mattoli V., Suzuki M., Ciofani G. Gold Nanoshell-Mediated Remote Myotube Activation. ACS Nano. 11 (3) 2494-2505 (2017); featured by Nature Nanotechnology 12: 188 (2017)

Pacini G., Marino A., Migliarini S., Brilli E., Pelosi B., Maddaloni G., Pratelli M., Pellegrino M., Ferrari A., Pasqualetti M. A Tph2GFP Reporter Stem Cell Line To Model in Vitro and in Vivo Serotonergic Neuron Development and Function. ACS Chemical Neuroscience. 8(5): 1043-1052 (2017)

Pezzini I., Marino A., Del Turco S., Nesti C., Doccini S., Cappello V., Gemmi M., Parlanti P., Santorelli F.M., Mattoli V., Micera S., Ciofani G. Cerium oxide nanoparticles, the regenerative redox machine in bioenergetic imbalance. Nanomedicine UK. 12(4): 403-416 (2016)

Marino A., Genchi G. G., Mattoli V., Ciofani G. Piezoelectric nanotransducers: The future of neural stimulation. Nanotoday. 14: 10-13 (2017)

Marino A., Tonda-Turo C., De Pasquale D., Ruini F.,Genchi G. G., Nitti S., Cappello V., Gemmi M., Mattoli V., Ciardelli G., Ciofani G. Gelatin/nanoceria nanocomposite fibers as antioxidant scaffolds for neuronal regeneration. Biochimica et Biophysica Acta (BBA) - General Subjects, 1861(2): 386-395 (2016)

Genchi G.G., Ceseracciu L., Marino A., Labardi M., Marras S., Pignatelli F., Bruschini L., Mattoli V., Ciofani G. P(VDF-TrFE)/BaTiO3 nanoparticle composite films mediate piezoelectric stimulation and promote differentiation of SH-SY5Y neuroblastoma cells. Advanced Healthcare Materials, 5(14): 1808-1820 (2016)

Genchi G.G., Marino A., Rocca A., Mattoli V., Ciofani G. Barium titanate nanoparticles: Promising multitasking vectors in nanomedicine. Nanotechnology, 27(23): 232001 (2016)

Genchi G.G., Nuhn H., Liakos I., Marino A., Marras S., Athanassiou A., Mattoli V., Desai T. Titanium Dioxide Nanotube Arrays Coated with Laminin Enhance C2C12 Skeletal Myoblast Adhesion and Differentiation. RSC Adv. 6(22): 18502-18514 (2016)

Rocca A., Marino A., del Turco S., Cappello V., Parlanti P., Pellegrino M., Golberg D., Mattoli V., Ciofani G. Pectin-coated boron nitride nanotubes: In vitro cyto- / immune-compatibility on RAW 264.7 macrophages. Biochimica et Biophysica Acta - General Subjects, 1860(4): 775-784 (2016)

Marino A., Barsotti J., de Vito G., Filippeschi C., Mazzolai B., Piazza V., Labardi M., Mattoli V., Ciofani G. Two-photon lithography of 3D nanocomposite piezoelectric scaffolds for cell stimulation. ACS Applied Materials and Interfaces, 7(46): 25574-25579 (2015)

Sergi P.N., Marino A., Ciofani G. Deterministic control of mean alignment and elongation of neuron-like cells by grating geometry: A computational approach. Integrative Biology, 7(10): 1242-1252 (2015)

Marino A., Arai S., Hou Y., Sinibaldi E., Pellegrino M., Chang Y.T., Mazzolai B., Mattoli V., Suzuki M., Ciofani G. Piezoelectric nanoparticle-assisted wireless neuronal stimulation. ACS Nano, 9(7): 7678-7689 (2015)

Ferreira T.H., Rocca A., Marino A., Mattoli V., de Sousa E.M.B., Ciofani G. Evaluation of the effects of gum Arabic functionalized boron nitride nanotubes on the differentiation of rat mesenchymal stem cells. RSC Advances, 5(56): 45431-45438 (2015)

Bernardeschi I., Greco F., Ciofani G., Marino A., Mattoli V., Mazzolai B., Beccai L. A soft, stretchable and conductive biointerface for mechanotransduction studies. Biomedical Microdevices, 17(2): 46 (2015)

Marino A., Filippeschi C., Mattoli V., Mazzolai B., Ciofani G. Biomimicry at the nanoscale: Current research and perspectives of two-photon polymerization. Nanoscale, 7(7): 2841–2850 (2015)

Ferreira T.H., Marino A., Rocca A., Liakos I., Nitti S., Athanassiou A., Mattoli V., Mazzolai B., de Sousa E.M.B., Ciofani G. Folate-grafted boron nitride nanotubes: Possible exploitation in cancer therapy. International Journal of Pharmaceutics, 481(1-2): 56-63 (2015)

Rocca A., Marino A., Rocca V., Moscato S., de Vito G., Piazza V., Mazzolai B., Mattoli V., Ngo-Anh T.J., Ciofani G. Barium titanate nanoparticles and hypergravity stimulation improve differentiation of mesenchymal stem cells into osteoblasts. International Journal of Nanomedicine, 10: 433-445 (2015)

Marino A., Desii A., Pellegrino M., Pellegrini M., Filippeschi C., Mazzolai B., Mattoli V., Ciofani G. Nano-structured Brownian surfaces prepared through two-photon polymerization: Investigation of stem cell response. ACS Nano, 8(11): 11869-11882 (2014)

Marino A., Filippeschi C., Genchi G.G., Mattoli V., Mazzolai B., Ciofani G. The Osteoprint: A two-photon polymerized 3D structure for the enhancement of bone-like cell differentiation. Acta Biomaterialia, 10(10): 4303-4313 (2014)

Marino A., Ciofani G., Filippeschi C., Pellegrino M., Pellegrini M., Pasqualetti M., Mattoli V., Mazzolai B. Two-photon polymerization of sub-micrometric patterned surfaces: Investigation of cell-substrate interactions and improved differentiation of neuron-like cells. ACS Applied Materials and Interfaces, 5(24): 13012-13021 (2013)

Publications on international peer-reviewed non-impacted journals

Genchi G.G., Marino A., Tapeinos C., Ciofani G. Smart materials meet multifunctional biomedical devices: current and prospective implications for nanomedicine. Frontiers in Bioengineering and Biotechnology. 5:1-8 (2017)

Genchi G.G., Rocca A., Marino A., Grillone A., Mattoli V., Ciofani G. Hypergravity As a Tool for Cell Stimulation: Implications in Biomedicine. Frontiers in Astronomy and Space Sciences. 3: 1-8 (2016)

Book chapter

Genchi G.G., Rocca A., Grillone A., Marino A., Ciofani G. Boron nitride nanotubes in nanomedicine: Historical and future perspectives. In "Boron Nitride Nanotubes in Nanomedicine", pp. 201-218, edited by Ciofani G., Mattoli V. (Elsevier, UK, 2016)

 

Proceedings of international conferences

Marino, A. Tricinci O., Battaglini M., Mattoli V., Sinibaldi E., Ciofani G. A 3D biomimetic model of the blood-brain barrier fabricated with a two-photon lithography approach. Proc. 29th European Conference on Biomaterials, 232 (2017)

Pezzini I., Marino A., Doccini S., Santorelli F. M., Ciofani G. Cerium oxide nanopaticles: a tool for rescuing the REEP1-related Hereditary Spastic Paraplegia (HSP) energetic imbalance. Proc. 29th European Conference on Biomaterials, 584 (2017)

Genchi G.G., Labardi M., Marino A., Ceseracciu L., Comito M., Sinibaldi E., Ciofani G. SaOS-2 osteoblast-like cells differentiation is enhanced by piezoelectric P(VDF-TrFE)/BNNTs composite films stimulated with ultrasounds. Proc. 29th European Conference on Biomaterials, 277 (2017)

Genchi G. G., Marino A., Ceseracciu L., Labardi M., Ciofani G. Poly(vinylidene difluoride-trifluoroethylene) smart piezoelectric composite films with boron nitride nanotubes for biomedical applications. 1st Biennial Conference on Biomaterials for Tissue and Genetic Engineering and the Role of Nanotechnology 223-226 (2016)

Marino A., Filippeschi C., Mattoli V., Mazzolai B., Ciofani G. Modulation of cellular responses: The two-photon polymerization approach in the control of the physical micro/nanoenvironment. Proc. 37th Annual International Conference of the IEEE EMBS, 1865-1868 (2015)

Bonisoli A., Marino A., Ciofani G., Greco F. Neuronal alignment and outgrowth on microwrinkled conducting polymer substrates. MRS Proceedings, 13-18 (2015)

Marino A., Barsotti J., Labardi M., Mazzolai B., Mattoli V., Ciofani G. Two-photon polymerization of Ormocomp® 3D structures doped with piezoelectric barium titanate nanoparticles. Proc. 27th European Conference on Biomaterials, 250 (2015)

Marino A., Filippeschi C., Mazzolai B., Mattoli V., Ciofani G. 3D direct laser writing of biomimetic structures for osteogenesis enhanchment. Proc. 26th European Conference on Biomaterials, 451 (2014)

Marino A., Rocca A., Rocca V., Moscato M., de Vito G., Piazza V., Mazzolai B., Mattoli V., Ngo-Anh J.T., Ciofani G. Hypergravity enhances nanoparticle up-take by stem cells: implications in biomedicine. Proc. 65th International Astronautical Conference, 269-272 (2014)

Rocca A., Marino A., Rocca V., Moscato S., de Vito G., Piazza V., Mazzolai B., Mattoli V., Ciofani G. Osteogenesis of mesenchymal stem cells: combined effects of hypergravity and barium titanate nanoparticles. Proc. 7th European Conference for Clinical Nanomedicine, 215-216 (2014)

Abstracts or posters presented at conferences

Marino A., Battaglini M., De Pasquale D., Ciofani G. Inhibition of breast cancer cell proliferation through nanoparticle-assisted piezoelectric stimulation. 5th Nano Today Conference, P8.39 (2017)

Marino A., Tonda-Turo C., de Pasquale D., Ruini F., Genchi G. G., Ciardelli G., Ciofani G. Nanoceria-doped gelatin nanofibers for neuronal regeneration. 5th International Conference on Multifunctional, Hybrid and Nanomaterials. 39 (2017)

Marino A., Arai S., Hou Y., Suzuki M., Ciofani G. Gold nanoshell-assisted wireless activation of myotube contraction. International Conference on Nanomedicine and Nanobiotechnology, OS3-101-3 (2016)

Degl'Innocenti A., Rossi L., Salvetti A., Marino A., Pellegrino M., Mazzolai B., Ciofani G. chlorophyll derivatives enhance planarian vision. 4th European Meeting on Planarian Biology, 40 (2016)

Genchi G.G., Marino A., Ceseracciu L., Labardi M., Mattoli V., Ciofani G. P(VDF-TrFE) and P(VDF-TrFE)/BaTiO3 nanoparticle composite films influence SH-SY5Y neuroblastoma cell behavior upon exposure to ultrasounds. 13th International Conference on Nanostructured Materials, 24.40 (2016)

Marino A., Arai A., Hou Y., Pellegrino M., Suzuki M., Ciofani G. Ultrasound-driven and nanoparticle-assisted wireless neural piezoelectric stimulation. 4th Nano Today Conference, 401, Q4-52 (2015)

Marino A., Mattoli V. Mazzolai B., Ciofani G. Direct laser writing and in vitro testing of bioinspired nano-structured scaffolds. 4th International Conference on Multifunctional, Hybrid and Nanomaterials, P2.318 (2015)

Ciofani G., Genchi G.G., Farrokhtakin E., Rocca A., Marino A., Mazzolai B., Mattoli V. Smart nanostructured materials in the biomedical research. 12th International Conference on Nanostructured Materials, 759 (2014)

Marino A., Ciofani G., Filippeschi C., Pasqualetti M., Mazzolai B. Direct laser writing of nanostructured scaffolds for the axonal guidance and for the promotion of the axonal outgrowth. 3rd Nano Today Conference, 246, P3-167 (2013)

Ferreira T.H., Ciofani G., Marino A., Mazzolai B., Mattoli V., De Sousa E.M.B. Innovative boron nitride nanoparticles - based vectors for cancer treatment. 22nd Brazilian Materials Research Society Meeting, 6JXY (2013)

Marino A., Ciofani G., Filippeschi C. Pasqualetti M., Mazzolai B. Direct Laser Writing of 2D/3D Nanostructured scaffolds for the investigation of neuron/substrate interactions in tissue engineering. Stem Cells 2013, London, UK (2013).

Pacini G., Marino A., Pelosi B., Migliarini S., Ferrari A., Pasqualetti M. A targeted serotonergic neuron reporter stem cell line to model in vitro serotonergic neuron development and function. IBRO, International Brain research Organization, (2011)

Pacini G., Marino A., Pelosi B., Migliarini S., Ferrari A., Pasqualetti M. La linea di cellule staminali embrionali Tph2-eGFP: un modello per lo studio in vitro dello sviluppo e del funzionamento dei neuroni serotoninergici. GEI, Gruppo Embriologico Italiano, (2011)

Pacini G., Migliarini S., Marino A., Pelosi B., Ferrari A., Pasqualetti M. Generation of an in vitro model for serotonergic neuron development and function. Serotonin Club Satellite Meeting, (2010)

Pacini G., Migliarini S., Marino A., Pelosi B., Pasqualetti M. A simple and reliable method to generate and study differentiating serotonergic neurons in vitro from murine ES cells. Congresso ABCD “Cellule staminali, Sviluppo e Medicina Rigenerativa”, (2010)

Pacini G., Migliarini S., Marino A., Pasqualetti M. A simple and reliable method to generate serotonergic neurons in vitro: generation of an in vitro sensor for serotonergic neuron differentiation, (2009)

Awards

- Cover image of issue of Small. In print. 2017 (doi: 10.1002/smll.201702959)

- Julia Polak European Doctoral Award 2017

- Winner of the Fondazione Umberto Veronesi Fellowship 2017

- Cover image of issue of Advanced Healthcare Materials, 6(9), May 2017

- Winner of the Spin Your Thesis! Campaign (2016), promoted by the ESA, presenting the experiment “Hypergravity-induced oxidative stress in planarians: nanotechnology-based countermeasures” (A. Marino, A. Grillone, I. Pezzini, D. De Pasquale; advisors prof. G. Ciofani, prof. A. Salvetti, dr. G.G. Genchi)

- Cover image of issue of Nanoscale, 2015, 7 (7), 2815–3320

- Winner of the “Salvatore Venuta” 2014 scholarship

- Winner of the travel grant awards for the following 4 conferences: i) 5th International Conference on Multifunctional, Hybrid and Nanomaterials, 2017, Lisbon (Portugal), ii) 4th Nano Today Conference; 2015, Dubai (United Arab Emirates) iii) EMBO Workshop on Stem Cell mechanobiology in development and disease; 2015 Capri (Italy). iv) 5th International Conference on Multifunctional, Hybrid and Nanomaterials. 39 (2017)

- “Arte o scienza?” photo-contest in 2015. The picture “Canestro e doppio canestro” was selected for the exhibition and won the second price

- Winner of the Spin Your Thesis! Campaign (2014), promoted by the ESA, presenting the experiment “Implementation of hypergravity in mammalian cell transfection procedures” (A. Rocca, A. Marino, A. Grillone, S. Gualtieri; advisors dr. G. Ciofani, dr. G.G. Genchi, dr. T.J. Ngo-Anh)

- Winner of the Spin Your Thesis! Campaign (2013), promoted by the European Space Agency (ESA), presenting the experiment: “Combination of hypergravity and nanotechnology for the improvement of the differentiation of mesenchymal stem cells into osteoblasts” (A. Marino, A. Rocca, V. Rocca; advisors dr. G. Ciofani, dr. T.J. Ngo-Anh)

 

 

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L’Istituto Italiano di Tecnologia (IIT) è una fondazione di diritto privato - cfr. determinazione Corte dei Conti 23/2015 “IIT è una fondazione da inquadrare fra gli organismi di diritto pubblico con la scelta di un modello di organizzazione di diritto privato per rispondere all’esigenza di assicurare procedure più snelle nella selezione non solo nell’ambito nazionale dei collaboratori, scienziati e ricercatori ”.

IIT è sotto la vigilanza del Ministero dell'Istruzione, dell'Università e della Ricerca e del Ministero dell'Economia e delle Finanze ed è stato istituito con la Legge 326/2003. La Fondazione ha l'obiettivo di promuovere l'eccellenza nella ricerca di base e in quella applicata e di favorire lo sviluppo del sistema economico nazionale. La costruzione dei laboratori iniziata nel 2006 si è conclusa nel 2009.

Lo staff complessivo di IIT conta circa 1440 persone. L’area scientifica è rappresentata da circa l’85% del personale. Il 45% dei ricercatori proviene dall’estero: di questi, il 29% è costituito da stranieri provenienti da oltre 50 Paesi e il 16% da italiani rientrati. Oggi il personale scientifico è composto da circa 60 principal investigators, circa 110 ricercatori e tecnologi di staff, circa 350 post doc, circa 500 studenti di dottorato e borsisti, circa 130 tecnici. Oltre 330 posti su 1400 creati su fondi esterni. Età media 34 anni. 41% donne / 59 % uomini.

Nel 2015 IIT ha ricevuto finanziamenti pubblici per circa 96 milioni di euro (80% del budget), conseguendo fondi esterni per 22 milioni di euro (20% budget) provenienti da 18 progetti europei17 finanziamenti da istituzioni nazionali e internazionali, circa 60 progetti industriali

La produzione di IIT ad oggi vanta circa 6990 pubblicazioni, oltre 130 finanziamenti Europei e 11 ERC, più di 350 domande di brevetto attive, oltre 12 start up costituite e altrettante in fase di lancio. Dal 2009 l’attività scientifica è stata ulteriormente rafforzata con la creazione di dieci centri di ricerca nel territorio nazionale (a Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) e internazionale (MIT ed Harvard negli USA) che, unitamente al Laboratorio Centrale di Genova, sviluppano i programmi di ricerca del piano scientifico 2015-2017.

IIT: the numbers

Istituto Italiano di Tecnologia (IIT) is a public research institute that adopts the organizational model of a private law foundation. IIT is overseen by Ministero dell'Istruzione, dell'Università e della Ricerca and Ministero dell'Economia e delle Finanze (the Italian Ministries of Education, Economy and Finance).  The Institute was set up according to Italian law 326/2003 with the objective of promoting excellence in basic and applied research andfostering Italy’s economic development. Construction of the Laboratories started in 2006 and finished in 2009.

IIT has an overall staff of about 1,440 people. The scientific staff covers about 85% of the total. Out of 45% of researchers coming from abroad 29% are foreigners coming from more than 50 countries and 16% are returned Italians. The scientific staff currently consists of approximately 60 Principal Investigators110 researchers and technologists350 post-docs and 500 PhD students and grant holders and 130 technicians. External funding has allowed the creation of more than 330 positions . The average age is 34 and the gender balance proportion  is 41% female against 59% male.

In 2015 IIT received 96 million euros in public funding (accounting for 80% of its budget) and obtained 22 million euros in external funding (accounting for 20% of its budget). External funding comes from 18 European Projects, other 17 national and international competitive projects and approximately 60 industrial projects.

So far IIT accounts for: about 6990 publications, more than 130 European grants and 11 ERC grants, more than 350 patents or patent applications12 up start-ups and as many  which are about to be launched. The Institute’s scientific activity has been further strengthened since 2009 with the establishment of 11 research nodes throughout Italy (Torino, Milano, Trento, Parma, Roma, Pisa, Napoli, Lecce, Ferrara) and abroad (MIT and Harvard University, USA), which, along with the Genoa-based Central Lab, implement the research programs included in the 2015-2017 Strategic Plan.