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Alessandro Simi


Research Line

Non-coding RNAs and RNA-based therapeutics


IIT Central Research Labs Genova


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Dr. Alessandro Simi obtained his BSc and MSc in Medical and Pharmaceutical Biotechnologies at the University of Genova and his PhD in Neuroscience and Brain Technologies at UniGe - Istituto Italiano di Tecnologia of Genova (IIT), under the coordination of Dr. Luca Berdondini, P.I. of the Microtechnology for Neuroelectronics lab, working on the characterization of neuronal networks activity and primary neural stem cells integration using in-vitro high-resolution microelectrode arrays. He moved to Lausanne (Switzerland) in Dr Mehdi Tafti’s group at the Center of Integrative Genomics (CIG) where he took part in the “Sleep-in-a-dish” research project studying sleep-like behavior in neuronal cortical cultures. Before joining the MINDED programme, he worked as a Postdoctoral Fellow in M. Studer’s lab at Institut de Biologie Valrose in Nice (France), where he investigated the role of transcription factors in cortical development and neurodevelopmental disorders. In January 2019 he received the MINDED Fellowship from the Marie Skłodowska-Curie group and moved back to IIT to start a new project on DNA transposon's role in cortical development.


Dr. Simi's MINDED project focuses on the role of transposable elements (DNA transposons and retrotransposons LINE-1) in cortical development. By combining in-vivo techniques and genomic analysis he is studying how transposable elements impact on the normal development of neocortical neurons and what is the link between transposable elements' machinery alteration and the onset of neurodevelopmental disorders.

The MINDED Project:

MINDED has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 754490.


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