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Giuliana Ottonello

Analytical Chemistry Facility
Technician
Analytical Chemistry
Phone
Research center
About

I have a Master’s degree in Chemistry and a Ph.D. in Chemical Sciences and Technologies focused on the development of analytical GC-MS methods for identification of environmental pollutants in food. I deepened my knowledge in the analytical chemistry field working for five years at the Ligurian Chemical Laboratory of the  Experimental Zooprophylactic Institute of Piemonte, Liguria e Valle d’Aosta, where we analyzed food to detect environmental pollutants, heavy metals, histamine, marine biotoxins and additives thus assuring food safety. In  2012 I joined the Analytical Chemistry Lab at IIT and I started to approach the world of Drug Discovery, dealing with in vitro ADME studies. Today, I’m in charge of most of the DMPK screening assays that our Lab performs such as solubility, metabolic stability, plasma protein binding and permeability assays. Moreover, I normally take part in external projects that involve other IIT Centres, universities or companies. I am among the invertors of Italian patent 102021000018455 “Biomarcatori della Malattia di Alzheimer” and I’m a co-author in 19 papers (2 as First).

Education

Title: Master's degree in Chemistry
Institute: University of Genoa
Location: Genova
Country: Italy
From: 2003 To: null

Title: Ph. D. degree in Chemical Sciences and Technologies
Institute: University of Genoa
Location: Genova
Country: Italy
From: 2011 To: null

All Publications
2021
Borgogno M., Savardi A., Manigrasso J., Turci A., Portioli C., Ottonello G., Bertozzi S.M., Armirotti A., Contestabile A., Cancedda L., De Vivo M.
Design, Synthesis,In VitroandIn VivoCharacterization of Selective NKCC1 Inhibitors for the Treatment of Core Symptoms in down Syndrome
Journal of Medicinal Chemistry, vol. 64, (no. 14), pp. 10203-10229
2020
Caputo S., Di Martino S., Cilibrasi V., Tardia P., Mazzonna M., Russo D., Penna I., Summa M., Mandrup Bertozzi S., Realini N., Margaroli N., Migliore M., Ottonello G., Liu M., Lansbury P., Armirotti A., Bertorelli R., Ray S.S., Skerlj R., Scarpelli R.
Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors
Journal of Medicinal Chemistry, vol. 63, (no. 24), pp. 15821-15851
2020
Arencibia J.M., Brindani N., Franco-Ulloa S., Nigro M., Kuriappan J.A., Ottonello G., Bertozzi S.M., Summa M., Girotto S., Bertorelli R., Armirotti A., De Vivo M.
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Journal of Medicinal Chemistry, vol. 63, (no. 7), pp. 3508-3521
2020
Brindani N., Gianotti A., Giovani S., Giacomina F., Di Fruscia P., Sorana F., Bertozzi S.M., Ottonello G., Goldoni L., Penna I., Russo D., Summa M., Bertorelli R., Ferrera L., Pesce E., Sondo E., Galietta L.J.V., Bandiera T., Pedemonte N., Bertozzi F.
Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators
Journal of Medicinal Chemistry, vol. 63, (no. 19), pp. 11169-11194
2020
Di Martino S., Tardia P., Cilibrasi V., Caputo S., Mazzonna M., Russo D., Penna I., Realini N., Margaroli N., Migliore M., Pizzirani D., Ottonello G., Bertozzi S.M., Armirotti A., Nguyen D., Sun Y., Bongarzone E.R., Lansbury P., Liu M., Skerlj R., Scarpelli R.
Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors
Journal of Medicinal Chemistry, vol. 63, (no. 7), pp. 3634-3664