IIT People Search

Gian Gaetano Tartaglia

Principal Investigator
Senior Researcher - Principal Investigator
RNA Systems Biology
Phone
Address
Research center
About
I graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons supervised by Brunello Tirozzi (Physics department). Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH with Amedeo Caflisch (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011. From 2010 and until 2020 I have been PI at the Centre for Genomic Regulation (CRG) in Barcelona directed by Miguel Beato (until 2012) and Luis Serrano (since 2012), in the research program of Roderic Guigo'. I was awarded an ERC grant in 2013 for my studies on the role of coding and non-coding transcripts in regulation of amyloid genes. In 2014 I was tenured in Catalonia as ICREA professor of Life and Medical Sciences. In December 2018 I became full professor of Biochemistry in the Department of Biology at University La Sapienza. In 2019 I started to work at IIT. In 2020 I was awarded an ERC grant for the study on the composition of phase-separated assemblies. This ERC is a Synergy grant and involves collaboration with Giancarlo Ruocco and Irene Bozzoni. In march 2020 I became PI at IIT where I lead the RNA System Biology lab. Together with the official members of the group, there are also Dr. Claudia Giambartolomei and Dr. Elsa Zacco from the Non-coding RNAs and RNA-based therapeutics lab. Elsa and Claudia are the pioneers of our RNA System Biology lab and joined IIT in early 2019. Jakob Rupert, PhD student from Sapienza university, is also member of Tartaglia's lab. Edoardo Milanetti, Lorenzo Di Rienzo and Mattia Miotto, previously in Anna Tramontano's group and now working at IIT CNLS with Giancarlo Ruocco are honorary members of the lab. Since September 2020 I am MAE (Member of Academia Europaea).
Education

Title: Clare Hall Research Fellow - Genetics and Chemistry
Institute: University of Cambridge
Location: Cambridge
Country: UK
From: 2007 To: 2010

Title: PhD - Biochemistry
Institute: University of Zurch
Location: Zuerich
Country: Switzerland
From: 2001 To: 2006

Title: MSc - Physics
Institute: University of Rome Sapienza
Location: Rome
Country: Italy
From: 1996 To: 2000

Skills

Protein-RNA Networks

Phase Separation

RNA Viruses

Computational Modelling

RNA Chemistry

All Publications
2022
Delli Ponti R., Broglia L., Vandelli A., Armaos A., Torrent Burgas M., Sanchez de Groot N., Tartaglia GG.
A high-throughput approach to predict A-to-I effects on RNA structure indicates a change of double-stranded content in non-coding RNAs
IUBMB Life
Article Journal
2022
Cava C., Armaos A., Lang B., Tartaglia G.G., Castiglioni I.
Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes
Scientific Reports, vol. 12, (no. 1)
2022
Arnal Segura M., Bini G., Fernandez Orth D., Samaras E., Kassis M., Aisopos F., Rambla De Argila J., Paliouras G., Garrard P., Giambartolomei C., Tartaglia GG.
Machine learning methods applied to genotyping data capture interactions between single nucleotide variants in late onset Alzheimer's disease.
Alzheimers and Dementia
2022
Vandelli A., Vocino G., Tartaglia G.G.
Phase Separation Drives SARS-CoV-2 Replication: A Hypothesis
Frontiers in Molecular Biosciences, vol. 9
Article Journal
2022
Cerase A., Calabrese J.M., Tartaglia G.G.
Phase separation drives X-chromosome inactivation
Nature Structural and Molecular Biology, vol. 29, (no. 3), pp. 183-185
Note Journal
Dissemination
2022
Tartaglia G.G.
This is Philosophy, about Aristotle
https://www.rtve.es/play/videos/this-is-philosophy/aristoteles/6297519/
Media
2021
Tartaglia G.G.
Big data and Artificial Intelligence in Biology
https://www.youtube.com/watch?v=3wL58kR_dYU
Media
2021
Tartaglia G.G.
L’unico compito di un virus è quello di riprodursi
https://opentalk.iit.it/lunico-compito-di-un-virus-e-quello-di-riprodursi/
Media
Scientific Talks
2022
Tartaglia G.G.
Protein and RNA Networks in Cellular Condensation
PhasAGE Training School
Workshop/Symposium
2022
Tartaglia G. G.
RNA in molecular crowding
Molecular Crowding Workshop Grenoble
Conference
2022
Tartaglia G.G.
The role of RNA in Phase separation
Physics of Biomolecules: Structure, Dynamics and Function
Conference
2021
Vocino G., Vandelli A., Tartaglia G.G.
COMPARATIVE ANALYSIS OF SARS-COV-2 GENOME INTERACTIONS WITH HUMAN PROTEINS
Bachelor’s Degree in Genomics
School (Summer school, ...)
2021
Tartaglia G.G.
Non-coding RNAs and phase separation rule the world”
EMBL in Italy 2021: A Brave New World of RNA, 20-21 May 2021 Virtual at the Italian Institute of Technology (IIT), Genoa
Conference
Awards and Achievements
2020
Tartaglia G.G.
ERC Award
2020
Tartaglia G.G.
Member of Academia Europaea
2019
Bozzoni I., Tartaglia G. G., Ruocco G.
ERC SyG ASTRA (https://erc.europa.eu/sites/default/files/document/file/erc-2019-syg-results.pdf)
2018
Tartaglia G.G.
Full Professor
2014
Tartaglia G.G.
ICREA Professor
Editorships
2019-2039
Tartaglia G.G.
Nucleic Acids Research Genomics and Bioinformatics
2015-2035
Tartaglia G.G.
Frontiers in Molecular Biosciences