Center for Life Nano Science

Center for Life Nano- & Neuro-Science

The IIT@Sapienza laboratory, born in 2010, revolves around two topics of biomedical interest where technological innovation is key to reach the goals.
The first regards neurodegenerative disorders, hereditary and sporadic conditions characterized by progressive nervous system dysfunction. The focus of the second will be brain tumours, the most life-threatening diseases of adulthood and childhood.
These challenging projects benefit from the establishment and convergence of common technological platforms. They avail themselves of state-of-the-art commercial equipment and, at the same time, foster and support the development of new techniques and instrumentation.

IIT Research Structures

Research Line

[CLN2S] Projects

Project A0320-2019-28124

Title: Optical cavity microscope for the diagnosis of deep skin lesions at terahertz frequencies
Acronym: MICOLET
Consortium: Sapienza Università di Roma, CRISEL Instruments S.R.L, Fondazione Istituto Italiano di Tecnologia

Deep skin lesions are among the main causes of hospitalization and death in the European Union. Current medical  diagnosis techniques are based on the surgical excision of skin in the  suspicious area (biopsies) and subsequent investigation with an optical  and/or fluorescence microscope. In this project we  will develop a microscopy device working at TeraHertz frequencies for  the non-invasive diagnosis of deep skin lesions with a new data  acquisition mode that will allow high-speed acquisitions and a compact volume of the instrument.

Total Budget € 635.509,23        Contribution € 418.659,13



[CLN2S] Projects 2

Project A0320-2019-28196

Title: Life Science Excellence Hub
Acronym: LSEH
Consortium: Sapienza Università di Roma, Istituto Superiore di Sanità,Consiglio Nazionale delle Ricerche,Università Cattolica del Sacro Cuore,Fondazione Istituto Italiano di Tecnologia,Università Campus Bio-Medico di Roma

LSEH is a regional center of excellence for Life Sciences aimed to aggregate, promote and enhance a set of 16 research and development projects resulting from the effective collaboration among companies, universities and research centers sited in Lazio. The main objective of LSEH is to be an active player in the process of knowledge and technology transfer for making the regional ecosystem competitive and innovative on a national and European scale in a key sector such as Life Sciences

Total Budget € 320.580,01      Contribution € 320.580,01


CLN2S - Contacts


Viale Regina Elena, 291
00161 Roma


IIT Publications List

Milanetti E., Miotto M., Di Rienzo L., Monti M., Gosti G., Ruocco G.
2D Zernike polynomial expansion: Finding the protein-protein binding regions
Computational and Structural Biotechnology Journal, vol. 19, pp. 29-36
Simonetti S., Natalini A., Peruzzi G., Nicosia A., Folgori A., Capone S., Santoni A., Di Rosa F.
A dna/ki67-based flow cytometry assay for cell cycle analysis of antigen-specific CD8 T cells in vaccinated mice
Journal of Visualized Experiments, vol. 2021, (no. 167), pp. 1-18
Dobrowolny G., Martone J., Lepore E., Casola I., Petrucci A., Inghilleri M., Morlando M., Colantoni A., Scicchitano B.M., Calvo A., Bisogni G., Chio A., Sabatelli M., Bozzoni I., Musaro A.
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients
Cell Death Discovery, vol. 7, (no. 1)
Grisanti G., Caprini D., Sinibaldi G., Scognamiglio C., Silvani G., Peruzzi G., Casciola C.M.
A microfluidic platform for cavitation-enhanced drug delivery
Micromachines, vol. 12, (no. 6)
Cappiello F., Carnicelli V., Casciaro B., Mangoni M.L.
Antipseudomonal and immunomodulatory properties of esc peptides: Promising features for treatment of chronic infectious diseases and inflammation
International Journal of Molecular Sciences, vol. 22, (no. 2), pp. 1-13