PhD degree in Life Science
Open University (UK) at the Ist. Europeo di Oncologia - Milan
POSTGEN: post-genomic technologies integration systems
IFOM Fondazione Istituto FIRC di Oncologia Molecolare - Milan
B.Sc. degree (5-year) in Biology (molecular biology specialization)
Università di Bari - Bari
Liceo Classico "O. Flacco" - Bari
Team Leader - Center for genomic science of IIT@SEMM (Milan) - Istituto Italiano di Tecnologia
Scientist - Molecular Medicine for Care Program- Dept. Experimental Oncology - (Milan) - IEO, European Institute of Oncology
Post-doctoral Fellow - IFOM, Firc-Institute for Molecular Oncology (Milan)
PhD student - IFOM, Firc-Institute for Molecular Oncology (Milan)
Research Fellow - Dept. Experimental Oncology - IEO, European Institute of Oncology (Milan)
Our lab focuses on functional analysis of microRNA and non-coding RNAs in development and cancer. Our current aims are:
Identification of miRNAs and non-coding RNAs in the control of stemness, cell cycle and differentiation.We are investigating the transcriptional regulation of miRNAs and how miRNA and mRNAs programs are integrated in the control of a physiological (i.e. stemness and differentiation) or pathological processes (i.e. oncogene-induced transformation). This will ultimately leads to the identification of key targets and mechanisms for cancer therapeutics. These studies will be also extended to the analysis of other non-coding RNAs and the investigation of their role in the control of gene expression programs.
Myc-depedent microRNAs in the transcriptional control of quiescence and proliferation. We aim at defining the effect of multiple miRNAs within the transcriptional framework that control cellular quiescence. In particular, we focus on Myc, a transcriptional factor widely known either as key controller of cell- cycle and quiescence and as master regulator of miRNA expression. Indeed, a core of specific genes that explain Myc effect in cell-cycle control is still missing, while a growing body of evidence suggests a key role for miRNAs in the control of proliferation and cell-cycle.
MicroRNAs and non-coding RNAs as biomarkers for cancer and disease. MicroRNAs are promising biomarkers due to their high tissue specificity and remarkable stability even in biological fluids (i.e. serum and plasma), where they provide a valuable source of circulating biomarkers for disease. We are interested in the development of miRNA signature for cancer risk prediction, early diagnosis, predict response to therapy and monitor disease recurrence. These studies will be also extended to the analysis of other non-coding RNAs as potential biomarkers for disease.
2011 “Fondazione Umberto Veronesi” Research Grant Award (2012-2013) “Identification of circulating non-coding RNAs as biomarkers for tumor diagnosis by “next-generation sequencing”.
2010 “Istituto Regina Elena Award” for the best oral presentation at the 52th Annual Meeting of the Italian Cancer Society.