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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
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About

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
2022
Pelloux Y., Rais C., Veggi M., Nava L., Gino A., Tonini R.
Involvement of dorsal raphe nucleus serotoninergic projection to the dorsal striatum on behavioural switching in a probabilistic discrimination task
GRC Basal Ganglia
Poster Conference
2022
Pelloux Y., Rais C., Veggi M., Nava L., Gino A., Tonini R.
Involvement of serotoninergic projections to the dorsal striatum in behavioral switching under uncertainty
FENS Forum 2022, Paris, France
Poster Conference
2022
Longaretti A., Mangoni D., Paget-Blanc V., Boender A.J., Pelloux Y., Lau P., Tartaglia G. G., Gustincich S., Tonini R.
LINE-1 long non-coding RNAs at striatal circuits contributes to the transition from flexible to inflexible behavioral control
FENS Forum 2022, Paris, France
Abstract Report Conference
2022
Longaretti A., Mangoni D., Paget-Blanc V., Boender A.J., Pelloux Y., Lau P., Tartaglia G. G., Gustincich S., Tonini R.
LINE-1 long non-coding RNAs at striatal circuits contribute to the transition from flexible to inflexible behavioral control
Cajal course “Neuroepigenetics : writing, reading and erasing the epigenome”
Abstract Report Conference
2022
Longaretti A., Mangoni D., Paget-Blanc V., Boender A.J., Pelloux Y., Lau P., Tartaglia G. G., Gustincich S., Tonini R.
LINE-1 long non-coding RNAs at striatal circuits contribute to the transition from flexible to inflexible behavioral control
GRC Basal Ganglia
Abstract Report Conference