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Pablo Martinez Canada

Optical Approaches to Brain Function
Research center

I am currently a Marie Sklodowska-Curie Fellow focused on answering the question:  Where does the electroencephalogram (EEG) come from?  By means of an interdisciplinary approach, combing advanced theoretical modeling with state-of-the-art multiscale neurophysiology and interventional techniques, I will address the above challenge. My goal is to develop rigorous mathematical tools to disambiguate the EEG and robustly interpret it in terms of specific neural features (e.g., firing rate). Such features are key elements in determining the neural microcircuit configuration and have been documented to contribute to important brain disorders such as schizophrenia and Autism Spectrum Disorders (ASD). These brain disorders result, at least in part, from anomalous changes in the functional organization and dynamics of neural circuits. However, we still do not know how to identify these atypical changes of neural dynamics in terms of the EEG signal. Ensuring healthy lives and promoting the well-being at all ages is a priority at European and global levels. Understanding the origins of EEG may increase the usability of EEG to diagnose brain disorders and predict treatment outcome success.

All Publications
Martínez Cañada P., Ness T. V., Einevoll G. T., Fellin T., Panzeri S.
Computation of the electroencephalogram (EEG) from network models of point neurons.
PLoS Computational Biology
Article Journal
Trakoshis S., Martinez-Canada P., Rocchi F., Canella C., You W., Chakrabarti B., Ruigrok A.N., Bullmore E.T., Suckling J., Markicevic M., Zerbi V., Bailey A.J., Baron-Cohen S., Bolton P.F., Bullmore E.T., Carrington S., Catani M., Chakrabarti B., Craig M.C., Daly E.M., Deoni S.C., Ecker C., Happe F., Henty J., Jezzard P., Johnston P., Jones D.K., Lai M.-C., Lombardo M.V., Madden A., Mullins D., Murphy C.M., Murphy D.G., Pasco G., Ruigrok A.N., Sadek S.A., Spain D., Stewart R., Suckling J., Wheelwright S.J., Williams S.C., Baron-Cohen S., Gozzi A., Lai M.-C., Panzeri S., Lombardo M.V.
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women
eLife, vol. 9
Article Journal
Schroder P., Martinez-Canada P., Amorim A., Fernandes P., Amorim-De-Sousa A., Gonzalez-Meijome J.M.
A Minimal-Model Approach to Analyze Neuronal Circuit Dynamics from multifocal ERG (mERG)
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 2955-2958
Conference Paper Conference
Martinez-Canada P., Morillas C., Pelayo F.
A Neuronal Network Model of the Primate Visual System: Color Mechanisms in the Retina, LGN and V1
International Journal of Neural Systems, vol. 29, (no. 2)
Conference Paper Journal
Martinez-Canada P., Mobarhan M.H., Halnes G., Fyhn M., Morillas C., Pelayo F., Einevoll G.T.
Biophysical network modeling of the dLGN circuit: Effects of cortical feedback on spatial response properties of relay cells
PLoS Computational Biology, vol. 14, (no. 1)