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Lampros Milanos

Post Doc
Senior Postdoctoral Medicinal Chemist

Research Line

Computational and Chemical Biology

Center

IIT Central Research Labs Genova

Contacts

Email: lampros.milanos@iit.it ----- Address: Via Adamello, 16, 20139 Milano, Italy

Social profiles

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About

Lampros received his bachelor’s degree in chemistry at the University of Ioannina in 2011. His bachelors thesis (Hons), under the supervision of Dr. Ioannis Elemes, focused on the synthesis of tetra-substituted alkenes via McMurry reaction and optimization of competitive ene reactions. In 2013, Lampros completed his master’s studies in medicinal chemistry at the University of Glasgow in Scotland. His master thesis was supervised by Dr. Joelle Prunet, and was based on the total synthesis of Paclitaxel.

Later on, Lampros moved to Germany and received his PhD at the University of Erlangen-Nuremberg funded by a GRK1910/DFG scholarship under the supervision of Dr. Nuska Tschammer and Prof. Timothy Clark. During his PhD, Lampros focused on developing allosteric biased small molecules with potential anti-inflammatory activity targeting the CXCR3 chemokine receptor as well as on identifying novel CXCR3 binding sites via advanced computational methods.

In 2016, Lampros completed his PhD with magna cum laude and started working in Dr Gabliela Chiosis' lab as postdoctoral research fellow at Memorial Sloan Kettering Cancer Center in New York. His project combined computer-aided drug design, synthesis and biological characterization of high potent Grp94 inhibitors, a chaperone protein with important roles in tumor development and metastasis.

Lampros joined the laboratory of Prof. Andrea Cavalli in June 2018 and works as an independent postdoc in Milan representing Prof. Andrea Cavalli’s lab. His research focuses on the design and development of novel small molecules inhibitors targeting various types of cancer.

Interests

Medicinal Chemistry Organic Synthesis Computational Chemistry CADD Tubulin Drug Discovery Anticancer Drugs GPCRs

Selected Publications

  • Brox, R.; Milanos, L.; Saleh, N.; Baumeister, P.; Buschauer, A.; Hofmann, D.; Heinrich, M. R.; Clark, T.; Tschammer, N., Molecular Mechanisms of Biased and Probe-Dependent Signaling at CXC-Motif Chemokine Receptor CXCR3 Induced by Negative Allosteric Modulators. Mol Pharmacol  2018, 93 (4), 309-322. [DOI]
  • Tschammer, N., Milanos, L.; Brox, R.; Agonists of the chemokine receptor CXCR3. WO/2017/063910, Apr 20, 2017. [DOI]
  • Milanos, L.; Saleh, N.; Kling, R. C.; Kaindl, J.; Tschammer, N.; Clark, T., Identification of Two Distinct Sites for Antagonist and Biased Agonist Binding to the Human Chemokine Receptor CXCR3. Angew Chem Int Ed Engl  2016, 55 (49), 15277-15281. [DOI]
  • Milanos, L.; Brox, R.; Frank, T.; Poklukar, G.; Palmisano, R.; Waibel, R.; Einsiedel, J.; Durr, M.; Ivanovic-Burmazovic, I.; Larsen, O.; Hjorto, G. M.; Rosenkilde, M. M.; Tschammer, N., Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3. J Med Chem  2016, 59 (5), 2222-43. [DOI]
 

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