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Annalisa De Angelis

Post Doc

Research Line

Neuroscience and society



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My research activity focuses on the development of innovative ultrasound transducer configurations based on constructive beam interference methods (Bessel beam diffraction, wavefront shaping) for non-invasive, focused, ultra-selective, deep and superficial brain stimulation. As a biomedical engineer, how to build a reliable and efficient device or system and how its modelling can derive globally emergent system characteristics, are the central questions that drive most of my research. Because real human systems are complex, answering these questions requires careful design and implementation that attends the details of the real scenario. Through the development of numerical realistic models, the microdosimetric analysis allows the exploration of the stimulation parameters (amplitude, phase, frequency of the ultrasonic signal; geometry and position of the transducers) and helps to understand the impact of each parameter on the effects induced in the brain by the ultrasound stimulation. The theoretical model act as a predictive tool for setting up the most suitable experimental or clinical procedure (controlled modulation of some specific neurological processes).

CV at a glance

  • 2019 – present Post-doc fellow at Center for Life Nanoscience CLNS@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.
  • 2018 – 2019 Post-doc fellow at ltalian lnter-University Centre of Electromagnetic Fields and Bio- Systems (ICEmB), University of Genoa, Italy.
  • 2014 – 2018 Post-doc fellow at Institute of Protein Biochemistry (IBP) – CNR Naples, Italy
  • 2012 – 2014 Specialist advisor for the scientific and technical publishing and divulgation of the project “Business Simulation for Health Care (BuS-4H)”in collaboration with SiliconDev, Italy.
  • 2009 – 2012 PhD student at Department of Photonics, Waves and Associate Systems, Institut de Recherche Xlim-CNRS, University of Limoges, France.
  • 2006 – 2009 Master of Science in Biomedical Engineering Sapienza, University of Rome, Italy                                                      
  • 2003 – 2006 Bachelor in Clinical Engineering Sapienza, University of Rome, Italy


Ultrasound brain stimulation numerical modelling wave-bio interaction


Graphical abstract IIT 2

Selected Publications

  1. De Angelis, A. Denzi, C. Merla, F.M. Andre, T. Garcia-Sanchez, L.M. Mir, F. Apollonio, and M. Liberti, "Confocal microscopy improves 3D microdosimetry applied to nanoporation experiments targeting endoplasmic reticulum", Front. Bioeng. Biotechnol., Accepted for publication. DOI: 10.3389/fbioe.2020.552261
  2. De Angelis, A. Denzi, C. Merla, F.M. Andre, T. Garcia-Sanchez, L.M. Mir, F. Apollonio, and M. Liberti, “Microdosimetric Realistic Model of a Cell with Endoplasmic Reticulum”, IEEE Engineering in Medicine and Biology, 41st EMB conference, 23-27 July 2019, Berlin, Germany.
  3. De Angelis, M. A. Ferrara, G. Coppola, L. Di Matteo, L. Siani, B. Dale, G. Coppola, A. C. De Luca, “Combined Raman and polarization sensitive holographic imaging for a multimodal label-free assessment of human sperm function,” Scientific Reports, vol. 9, 2019.
  4. Romano, A. De Angelis, A. Poli, P. Ragni, L. Lilla, G. Zito, B. Nicolaus, A. C. De Luca, P. Di Donato, “Resistance and Raman spectroscopy analysis of Parageobacillus thermantarcticus spores after g-ray exposure,” Extremophiles, vol. 22, 2018.
  5. De Angelis, A. Labruyère, V. Couderc, P. Leproux, A. Tonello, H. Segawa, M. Okuno, H. Kano, D. Arnaud-Cormos, P. Leveque, and H. Hamaguchi, “Time-frequency resolved analysis of a nanosecond supercontinuum source dedicated to multiplex CARS application,” Optics Express, Vol. 20, Issue 28, pp. 29705-29716, December 2012.


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