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Gabriella Panuccio

Researcher - Principal Investigator
Enhanced Regenerative Medicine
Research center

I am a Medical Doctor and I hold a Ph.D. in Biophysics. I use brain slice electrophysiology techniques (field potential, MEA, patch-clamp, sharp electrode recording) to study neuronal electrical activity in health and disease both at the single neuron and at the network level. I have a strong background in epilepsy research and a multidisciplinary expertise including neurophysiology, theoretical neuroscience and neural engineering, built across 20 years of national and international research experience, started with my MD Thesis.

My scientific work focuses on the development of intelligent biohybrid systems for functional brain repair, that would be capable of self-reconfiguration to recover the function of diseased brain circuits by dynamically interacting with them, thus being tailored to the individual.

In the context of the H2020 MSCA-IF founded project Re.B.Us. I have pushed forward the joint exploitation of biological and artificial components based on unidirectional and bidirectional closed-loop architectures to demonstrate the feasibility of reconnecting disconnected limbic area via biohybrid bridging, ultimately deploying this paradigm in a biohybrid graft-host interaction to cure temporal lobe epilepsy. www.rebus-project.eu

I currently coordinate the H2020-FET-PROACTIVE project HERMES joining a multidisciplinary EU consortium of 12 partners (~60 people to date) with expertise in neurobiology, neurophysiology and biophysics, stem cell biotechnology, biomaterials, tissue bioengineering, materials science, neuromorphic engineering, machine learning and AI, ethics and philosophy. www.hermes-fet.eu

The long-term vision of HERMES is healing disabling brain disorders by means of brain tissue transplants, a reality that is only possible to date for other organs of the human body. To overcome the biological uncertainty of canonical regenerative approaches, HERMES proposes an innovative solution based on intelligent biohybrids in which the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence effectively pursues a self-repair process of dysfunctional brain circuits.

In light of its vision, HERMES fosters the emergence of a novel paradigm to heal rather than treat the diseased brain. This paradigm is named enhanced regenerative medicine and is rooted in the establishment of biohybrid neuronics (neural electronics), bringing together the best of biological and artificial worlds to allow for controlled brain regeneration.

All Publications
Garcia-Retuerta D., Canal-Alonso A., Casado-Vara R., Rey A.M.-D., Panuccio G., Corchado J.M.
Bidirectional-Pass Algorithm for Interictal Event Detection
Advances in Intelligent Systems and Computing, vol. 1240 AISC, pp. 197-204
Conference Paper Book Series
Subramaniyam N.P., Donner R.V., Caron D., Panuccio G., Hyttinen J.
Causal coupling inference from multivariate time series based on ordinal partition transition networks
Nonlinear Dynamics, vol. 105, (no. 1), pp. 555-578
Article Journal
Forro C., Caron D., Angotzi G.N., Gallo V., Berdondini L., Santoro F., Palazzolo G., Panuccio G.
Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology
Micromachines, MDPI, vol. 12, (no. 2)
Review Journal
Decimo I., Dolci S., Panuccio G., Riva M., Fumagalli G., Bifari F.
Meninges: A Widespread Niche of Neural Progenitors for the Brain
Neuroscientist, vol. 27, (no. 5), pp. 506-528
Panuccio G., Fdez-Riverola F., Casado-Vara R., Rocha M., Mohamad M.S.
Advances in Intelligent Systems and Computing, vol. 1240 AISC, pp. v-vi
Editorial Book Series
Panuccio G.
Simbiosi bioartificiali per rigenerare il cervello
Public Event
Panuccio G.
The HERMES Project: ENhancing the Future of Brain Regeneration
Panariello Scientifico
Public Event
Panuccio G., Chiappalone M., Colombi I.
Da grande voglio fare il neuroscienziato
Istituto Comprensivo Sanvitale Fra Salimbene
Scientific Talks
Panuccio G.
The HERMES Project – Enhancing the Future of Brain Regeneration
Osnabrück University
Panuccio G.
Enhanced Regenerative Medicine: Where Biology and Engineering Meet
UK Circuits and Systems (UKCAS) for Biomedical Applications
Oral presentations
Panuccio G., Avoli M.
Subiculum, GABAergic inhibition and temporal lobe epilepsy Subiculum, inibizione GABAergica ed epilessia del lobo temporale
Bollettino - Lega Italiana contro l'Epilessia, (no. 142), pp. 92-95