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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
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About

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
2021
Peters K.Z., Cheer J.F., Tonini R.
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System
Trends in Neurosciences, vol. 44, (no. 6), pp. 464-477
Review Journal
2021
Boender A.J., Bontempi L., Nava L., Pelloux Y., Tonini R.
Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2
Biological Psychiatry, vol. 89, (no. 11), pp. 1045-1057
Article Journal
2020
Pagani M., Bertero A., De Felice A., Locarno A., Miseviciute I., Trakoshis S., Canella C., De Guzman E., Supekar K., Menon V., Galbusera A., Tonini R., Lombardo M.V., Pasqualetti M., Gozzi A.
A cross-species link between deficient synaptic pruning and functional hyper-connectivity in autism
Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Poster Conference
2020
Pagani M., Bertero A., De Felice A., Locarno A., Miseviciute I., Trakoshis S., Canella C., De Guzman E., Supekar K., Menon V., Galbusera A., Tonini R., Lombardo M.V., Pasqualetti M., Gozzi A.
A cross-species link between mTOR-dependent deficient synaptic pruning and functional hyper-connectivity in autism
INSAR
Poster Conference
2020
Pagani M., Bertero A., Trakoshis S., Ulysse L., De Felice A., Locarno A., Miseviciute I., Trakoshis S., Canella C., De Guzman E., Supekar K., Menon V., Galbusera A., Tonini R., Deco G., Lombardo M.V., Pasqualetti M., Gozzi A.
A cross-species link between mTOR-dependent hyperactivity and functional over-connectivity in autism
OHBM ANNUAL MEETING
Poster Conference