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Matteo Marzi

Senior Post Doc
Genomic Science
Research center

I'm a biotechnologist who has trained in genomic science, with over 10 years of experience in non-coding RNA Biology. My main interest is in the role of ncRNAs in differentiation and in cancer and, more specifically, in their ability to modify the expression of genes, shaping cell fate. My scientific approach is characterized by the exploitation of genome-wide approaches, novel technologies and bioinformatics.


Title: PhD in Molecular Medicine
Institute: Università di Milano, European School Of Molecular Medicine (SEMM)
Location: Milan
Country: Italy
From: 2007 To: 2010

Title: Laurea Magistrale in Biotecnologie Farmaceutiche
Institute: Università di Milano
Location: Milan
Country: Italy
From: 2000 To: 2006


ncRNA biology
- Detection and Manipulation of non coding RNAs by CRISPRi/a/KO, GAPMERs, shRNA, etc.

Single Cell/Molecule Sequencing
- sc-RNA-seq
- sc-ATAC-seq

CRISPR functional Screenings
- Cell Tracking

Cancer Biology
- Breast Cancer models
- Cancer stem cells
- 3D cell culture

Next Gen Seq
- small RNA-seq
- RNA-seq
- ATAC-seq

Top Publications
Simeone I., Rubolino C., Noviello T.M.R., Farinello D., Cerulo L., Marzi M.J., Nicassio F.
Prediction and pan-cancer analysis of mammalian transcripts involved in target directed miRNA degradation
Nucleic Acids Research, vol. 50, (no. 4), pp. 2019-2035
Article Journal
Ghini F., Rubolino C., Climent M., Simeone I., Marzi M.J., Nicassio F.
Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation
Nature Communications, vol. 9, (no. 1)
Marzi M.J., Ghini F., Cerruti B., De Pretis S., Bonetti P., Giacomelli C., Gorski M.M., Kress T., Pelizzola M., Muller H., Amati B., Nicassio F.
Degradation dynamics of micrornas revealed by a novel pulse-chase approach
Genome Research, vol. 26, (no. 4), pp. 554-565
Montani F., Marzi M.J., Dezi F., Dama E., Carletti R.M., Bonizzi G., Bertolotti R., Bellomi M., Rampinelli C., Maisonneuve P., Spaggiari L., Veronesi G., Nicassio F., Di Fiore P.P., Bianchi F.
MiR-test: A blood test for lung cancer early detection
Journal of the National Cancer Institute, vol. 107, (no. 6)
Muller H., Marzi M.J., Nicassio F.
IsomiRage: From functional classification to differential expression of miRNA isoforms
Frontiers in Bioengineering and Biotechnology, vol. 2, (no. SEP)
Article Journal