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Jean-Charles Rene' Pasquin Mariani

Post Doc
Functional Neuroimaging
Research center

I am a neuro-computationalist. Having a bachelor in mathematics, I graduated as an engineer from ESPCI Paris with a major in physics and specialised in biophysics. I later pursued an additional master of research working with Paul Chadderton and Stephen Brickley at the Imperial College of London, where I learned patch clamp recording.

Since then, I investigated system neuroscience for preclinical applications by doing my PhD at INSERM in Zsolt Lenkei's team using functional ultrasound. During this project I went from the bench of animal research to the desk of computationalists developing a end-to-end pipeline for the acquisition and analysis of non-invasive resting state functional connectivity in awake and behaving mice. Thanks to this method we discovered fingerprints of pharmacological treatments (opioids, cannabinoids and psilocybin) in the functional connectivity of vigile mice opening the way for fast and parallel screening of new therapies based on whole brain function. 

I am now orienting my work towards whole brain modelling to leverage neuroimaging methods (resonance magnetic imaging and ultrafast ultrasound imaging) and better understand the mechanisms underlying functional connectivity and brain dynamics at the macroscale. 


Title: Bachelor in mathematics and computer science (preparatory school for the national exam)
Institute: Lycee Saint Louis
Location: Paris
Country: France
From: 2011 To: 2014

Title: MEng, Adv. MSc.
Institute: ESPCI Paris PSL (Ecole Superieure de Physique et de Chimie Industrielle de la ville de Paris)
Location: Paris
Country: France
From: 2014 To: 2017

Title: MRes
Institute: Imperial College London
Location: Paris
Country: France
From: 2017 To: 2018

Title: PhD
Institute: Institute of Psychiatry and Neuroscience INSERM ; Center for interdisciplinary Research - Universite de Paris Cite
Location: Paris
Country: France
From: 2018 To: 2023

All Publications
Montadi C., Galbusera A., D'Epifanio B., Ghirardini E., Cornuti S., Mariani JC., De Guzman A. E., Mandrup Bertozzi S., Armirotti A., Baroncelli L., Gozzi A.
Connectomic and behavioral alterations in creatine transporter deficiency are partially normalized by gene therapy
Article E-print Archive
Mariani JC.
Quantification and modelling of functional connectivity perturbation in ultrafast power doppler imaging of the awake mice brain : pharmacological fingerprints on awake brain activity
PhD Thesis Book
Bourgeais-Rambur L., Beynac L., Mariani J.-C., Tanter M., Deffieux T., Lenkei Z., Villanueva L.
Altered Cortical Trigeminal Fields Excitability by Spreading Depolarization Revealed with in Vivo Functional Ultrasound Imaging Combined with Electrophysiology
Journal of Neuroscience, vol. 42, (no. 32), pp. 6295-6308
Article Journal
Csaszar E., Lenart N., Cserep C., Kornyei Z., Fekete R., Posfai B., Balazsfi D., Hangya B., Schwarcz A.D., Szabadits E., Szollosi D., Szigeti K., Mathe D., West B.L., Sviatko K., Bras A.R., Mariani J.-C., Kliewer A., Lenkei Z., Hricisak L., Benyo Z., Baranyi M., Sperlagh B., Menyhart A., Farkas E., Denes A.
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Journal of Experimental Medicine, vol. 219, (no. 3)
Bertolo A., Nouhoum M., Cazzanelli S., Ferrier J., Mariani J.-C., Kliewer A., Belliard B., Osmanski B.-F., Deffieux T., Pezet S., Lenkei Z., Tanter M.
Whole-brain 3d activation and functional connectivity mapping in mice using transcranial functional ultrasound imaging
Journal of Visualized Experiments, vol. 2021, (no. 168)