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Irene Bozzoni

Principal Investigator - Principal Investigator
Non coding RNAs in Physiology and Pathology
Phone
Research center
About

Current Positions

Since 1994: Full Professor of Molecular Biology, University of Rome.

Since 2018:  Senior Researcher at the Italian Institute of Technology (IIT).

Academic career and research experience

2002:               Visiting Professor at the University of Brandeis, Boston – USA (Prof. M. Rosbash),

1994-present:  Full Professor of Molecular Biology, University of Rome  

1993:               Visiting Professor at the University of Boulder, Colorado - USA (Prof. O. Uhlenbeck)

1986-1994:      Associate Professor of Molecular Biology, University of Rome

1986:               Visiting Professor at the National Institute of Health of Bethesda (USA)

1980-1986:      Staff scientist at the Center for Nucleic Acid Research, CNR, Rome, Italy

1985:               Visiting Scientist at the University of Zurich - CH (Prof.M. Birnstiel)

1978-1980:      Research fellow at the Centro Acidi Nucleici of C.N.R., Rome

1979:               EMBO fellow at the European Molecular Biology Laboratory, Heidelberg( - Germany (Dr. M.L. Melli)

1977-78:          Post-doctoral fellow - Institute of Molecular Biology, University of Zurich -CH (Prof.M. Birnstiel)

Academic assignments

Since 2020: Honorary Fellow at the School for Advanced Studies of Sapienza University of Rome

2016-2018:      Director of the School for Advanced Studies of Sapienza

2007- 2018:     Director of the Master Degree in Genetics and Molecular Biology – Sapienza, University of Rome.

2011-2016:      Deputy Director of the School of Advanced Studies of Sapienza

2000-2016:      Member of the PhD Committee of Sapienza University.

2011-2014:      President of the Evaluation Committee of the Faculty of Sciences, Sapienza University of Rome.

2009-2012:      Member of the Committee for the Innovation of Research and Technology, Sapienza University

2005-2016:      Rappresentative of Sapienza University at the “Consorzio Interuniversitario per le Biotecnologie”.

2007- 2015:     Member of the Technical and Scientific Committee of the Consorzio Sapienza Innovazione of the University La   Sapienza and of the Italian Federation for Life Sciences.

Non academic engagements

Since 2020: member of the “Scientific Advisory Committee” of the European Molecular Biology Laboratory (EMBL)

2018-present:  Member of the “Management Committee” of the Human Technopole.

2018-present:  Member of the Advisory Committee dell'Armenise-Harvard Foundation.

2017-present:  Member of the Board of the “Museo Nazionale della Scienza e della Tecnologia, Leonardo da Vinci",

Milan.

2015- present: Member of the Scientific Advisory Board of the “Enciclopedia Treccani”.

2012-2018:      Review panel member of the Rita Levi-Montalcini “Program on Young Researchers” of the Ministry of Research and University (MIUR).

2016-2018:      Member of the National Committee for the abilitation of Full Professors and Associate Professors in Molecular Biology

2016:               ERC - Review panel member for ERC, LS3 Consolidator Grants (CoG)

2011-2014:      Member of the Review panel member of the membership committee of EMBO

2010-2013:      Member of the Scientific Advisory Board of the “Committee of Experts for the Research Policy” (CEPR), consultant of the of the Italian Ministry of University and Research

2009-2012:      Member of the Scientific Advisory Board of the Pezcoller Foundation

2005-2008:      Member of the Scientific Advisory Board of Armenise-Harvard Foundation

2000-2003:      Member of the Scientific Advisory Board of the “Fondazione Chiara D'Onofrio”

Evaluator for: ESF, AERES, Welcome Trust, EMBO, HFSP, Armenise-Harvard Foundation, AFM and several international scientific institutions.

Memberships, honors and awards

  • In 2013 was awarded of an ERC-Advanced Grant
  • In 2010 was awarded the "Sapienza Ricerca Award"
  • In 2008 was invited to give the “Lectio magistralis” for the inauguration of the academic year at Sapienza, University of Rome
  • In 2003 and 2006 was awarded two Prizes by the Accademia Nazionale dei Lincei.
  • Member of European Molecular Biology Organization (EMBO) and of the "Academia Europaea"
  • Member of Italian Society for Biophysics and Molecular Biology
  • Member of the “Accademia Medica”


Research projects coordinated:

- European Union - VII Research Framework:

ERC-Advanced Grant - Muncodd

People-MSCA- ITN, RNATRAIN Project

RIGHT, Integrated Project

SIROCCO, Integrated ProjecSP3-

- European Union – Horizon 2020:

2016 -Marie Sklodowska Curie Actions -ITN, “circRTrain

- European Science Foundation (ESF)

- Human Frontier Science Program (HFSP)

- French Muscular Dystrophy Association (AFM-Téléthon) 

- MIUR (PRIN, FIRB)

- Fondazione Telethon

- ARISLA

- Associazione Italiana per la Ricerca Sul Cancro (AIRC)

- Istituto Pasteur, Fondazione Cenci-Bolognetti

- Parent Project ONLUS

- Istituto Italiano di Tecnologie (IIT) –SEED projects


Projects


Currently coordinated research projects:

- H2020 - ERC-2019-SyG

Project: 855923 — ASTRA

“Assembly and phase Transitions of Ribonucleoprotein Aggregates in neurons: from physiology to pathology”

- AIRC –Progetto IG-2019  Id.23053

“Circular RNAs: novel players and biomarkers in tumorigenesis”

European Union – Horizon 2020:

2016 -Marie Sklodowska Curie Actions -ITN, “circRTrain”

PRIN  2017

Prot. 2017P352Z4

“Non coding RNAs, new players in gene expression regulation: studying their role in neuronal differentiation and in neurodegeneration”


Previous

  • European Union - VII Research Framework:
  • ERC-Advanced Grant - Muncodd
  • People-MSCA- ITN, RNATRAIN Project
  • Fondazione Telethon
  • Istituto Pasteur, Fondazione Cenci-Bolognetti
  • Arisla
  • HFSP
  • ASM



Awards


  • In 2013 was awarded of an ERC-Advanced Grant
  • In 2010 was awarded the "Sapienza Ricerca Award".
  • In 2008 was invited to give the “Lectio magistralis” for the inauguration of the academic year at Sapienza, University of Rome
  • In 2003 and 2006 was awarded two Prizes by the Accademia Nazionale dei Lincei.
  • Member of European Molecular Biology Organization (EMBO) and of the "Academia Europaea"
  • Member of Italian Society for Biophysics and Molecular Biology
  • Member of the “Accademia Medica”

Education

Title: degree in Biology
Institute: “Sapienza” University of Rome
Location: Rome
Country: Italy
From: 1971 To: 1975

Title: specialization in General Pathology
Institute: “Sapienza” University of Rome
Location: Rome
Country: Italy
From: 1975 To: 1978

All Publications
2021
Dobrowolny G., Martone J., Lepore E., Casola I., Petrucci A., Inghilleri M., Morlando M., Colantoni A., Scicchitano B.M., Calvo A., Bisogni G., Chio A., Sabatelli M., Bozzoni I., Musaro A.
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients
Cell Death Discovery, vol. 7, (no. 1)
Article Journal
2020
Di Timoteo G., Rossi F., Bozzoni I.
Circular RNAs in cell differentiation and development
Development (Cambridge), vol. 147, (no. 16)
Review Journal
2020
Reinoso-Sanchez J.F., Baroli G., Duranti G., Scaricamazza S., Sabatini S., Valle C., Morlando M., Casero R.A., Bozzoni I., Mariottini P., Ceci R., Cervelli M.
Emerging role for linear and circular spermine oxidase rnas in skeletal muscle physiopathology
International Journal of Molecular Sciences, vol. 21, (no. 21), pp. 1-19
2020
Humphrey J., Birsa N., Milioto C., McLaughlin M., Ule A.M., Robaldo D., Eberle A.B., Krauchi R., Bentham M., Brown A.-L., Jarvis S., Bodo C., Garone M.G., Devoy A., Soraru G., Rosa A., Bozzoni I., Fisher E.M.C., Muhlemann O., Schiavo G., Ruepp M.-D., Isaacs A.M., Plagnol V., Fratta P.
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
Nucleic Acids Research, vol. 48, (no. 12), pp. 6889-6905
2020
Desideri F., Cipriano A., Petrezselyova S., Buonaiuto G., Santini T., Kasparek P., Prochazka J., Janson G., Paiardini A., Calicchio A., Colantoni A., Sedlacek R., Bozzoni I., Ballarino M.
Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1
Cell Reports, vol. 33, (no. 12)
Dissemination
2019
Bozzoni I.
La ricerca medica in Europa
Lezioni aperte sull' Europa. Storia, Economia, Scienze, Cultura.
Outreach
2019
Bozzoni I.
Le malattie rare.
Festival della Salute Globale. Padova, Italy.
Outreach
2019
Bozzoni I.
Le nuove frontiere delle Scienze della vita nell’era post-genomica.
IX Festa Scienza e Filosofia. Foligno, Italy
Outreach
Scientific Talks
2020
Bozzoni I.
Advanced topics in medical genetics
September 29th - October 3rd 2020- GCGC2020 Italy-Iran meeting - in remote
Conference
2020
Bozzoni I.
Decoding non-coding RNA function
LIFE SCIENCE 2020, 3rd Joint Annual Symposium of the Departments of Biology and Biotechnology, Molecular Medicine and CNR-Institute of Molecular Genetics
Conference
2018
Bozzoni I.
Come le alterazioni dell’espressione degli RNA sono coinvolte nell’insorgenza della SLA
Simposio FOCUS SLA. Genova, Italia
Workshop/Symposium
2018
Bozzoni I.
“Decoding non coding RNA function"
8th BeMM Symposium. Rome, Italy
Workshop/Symposium
2018
Bozzoni I.
Decoding non coding RNA function
EMBO Workshop From epigenome towards epitranscriptome in cell fate choice | Capri, Italy
Workshop/Symposium