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Marta Pace

Post Doc
Postdoc

Research Line

Genetics and Epigenetics of Behavior

Center

IIT Central Research Labs Genova

Contacts

Via Morego 3
00393200767497

About

  1. Pace M,Camilo M, Seiler A, Duss S,Mathis J, Manconi M, Bassetti C. (2016) Rapid eye movements sleep as a predictor of functional outcome after stroke: A translational study .Sleep. 2018 Oct 1;41(10). § corresponding author
  2. Pincherle A*, Pace M*, Dirnagl U, Bassetti C. (2016) Sleep, Preconditionig and stroke. Stroke. 2017 Dec;48(12) *shared  first authorship (Review)
  3. Pace M, Adamantidis A. Bassetti C. Role of REM sleep and melanin concentrating hormone in the neuroprotective effect of sleep deprivation pre-ischemia. PLoS One. 2017 Jan 6;12(1) 
  • § corresponding author
  1. Pace M, Baracchi F, Gao B, Bassetti C. Identification of sleep-modulated pathways involved in neuroprotection from stroke. Sleep. 2015 Nov 1;38(11)
  2. Notturno F,* Pace M*, Zappasodi F, Cam E, Bassetti C, Uncini A. Neuroprotective effect of cathodal transcranial direct current stimulation in a rat stroke model. J Neurol Sci. 2014 Jul 15;342(1-2) *shared first authorship
  3. Notturno F*, Pace M*, De Angelis MV, Caporale CM, Giovannini A, Uncini A.Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene.J Neuroimmunol. 2008 Jul 15;197(2):124-7. *shared first authorship
  1. Duss S.B., Seiler A., Schmidt M., Pace M., Adamantidis A., Müri R., Bassetti C. The role of sleep in recovery following ischemic stroke: A review of human and animal data. Neurobiology of Sleep and Circadian Rhythms 2017 Jan (Review)
  2. Silvani A, Lo Martire A, Salvadè A, Bastianini S, Ferri R, Berteotti C, Baracchi F, Pace M, Bassetti C, Zoccoli G, Manconi M. Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats, and humans. J Sleep Res. 2015 Jun 25.
  3. Salvatore G, Salvadè A, Pace M, Sarasso S, Baracchi F, Bassetti C, Kaelin-Lang A, Städler C, Stanzione P, Möller J. Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease. Neurobiol Aging. 2015 Mar
  4. Di Lazzaro V, Manganelli F, Dileone M, Notturno F, Esposito M, Capasso M, Dubbioso R, Pace M, Ranieri F, Minicuci G, Santoro L, Uncini A.The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex.J Neural Transm. 2012 Jun 19.
  5. Caporale CM, Notturno F, Pace M, Aureli A, Di Tommaso V, De Luca G, Farina D, Giovannini A, Uncini A.CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):175-83.
  6. Uncini A, Notturno F, Pace M, Caporale CM.Polymorphism of CD1 and SH2D2A genes in inflammatory neuropathies.Peripher Nerv Syst. 2011 Jun;16 
  7. Capasso M, Di Muzio A, Pandolfi A, Pace M, Di Tomo P, Ragno M, Uncini A.Possible role for nitric oxide dysregulation in critical illness myopathy.Muscle Nerve. 2008 Feb;37(2):196-202.
  8. De Angelis MV, Notturno F, Caporale CM, Pace M, Uncini A.Polymorphisms of CD1 genes in chronic dysimmune neuropathies.J Neuroimmunol. 2007 May;186(1-2):161-3.
  9. Scarciolla O, Stuppia L, De Angelis MV, Murru S, Palka C, Giuliani R, Pace M, Di Muzio A, Torrente I, Morella A, Grammatico P, Giacanelli M, Rosatelli MC, Uncini A, Dallapiccola B.Spinal muscular atrophy genotyping by gene dosage using multiple ligation-dependent probe amplification. Neurogenetics. 2006 Nov;7(4):269-76.
  10. Capasso M, De Angelis MV, Di Muzio A, Scarciolla O, Pace M, Stuppia L, Comi GP, Uncini A. Familial idiopathic hyper-CK-emia: an under recognized condition. Muscle Nerve. 2006 Jun;33(6):760-5

Projects

Prader-Willi syndrome (PWS) is a paternally imprinted disorder that leads to sleep, feeding alterations, and temperature instability. It is usually characterized by hypothalamic dysfunctions. Since, the lateral hypothalamus (LH), and its neuronal population, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) neurons are strongly implicated in the regulation of sleep-wake cycle and feeding behavior, we postulate that MCH and OX represent a key component in the pathophysiology of PWS. Specifically, we hypothesized that MCH and OX neurons do not function correctly in the PWS. 

In order to test this hypothesis, we designed a three-step research strategy: 

1) observational approach:neuronal activity of the LH and its neuronal population (i.e MCH and OX neurons) will be assessed in mice lacking the Snord116gene.

2) functional approach:the role of Snord116 in the control of MCH and OX neuronal functions will be investigated by using gene modification technology

3) interventional approach:manipulation of MCH and OX by pharmacological approach will be performed. 

By clarifying the role in of the LH and the two neuronal populations in PWS, we will pave the way for a rescue of the sleep-wake and feed abnormalities.

Selected Publications

  1. Pace M,Camilo M, Seiler A, Duss S,Mathis J, Manconi M, Bassetti C. (2016) Rapid eye movements sleep as a predictor of functional outcome after stroke: A translational study .Sleep. 2018 Oct 1;41(10). § corresponding author
  2. Pincherle A*, Pace M*, Dirnagl U, Bassetti C. (2016) Sleep, Preconditionig and stroke. Stroke. 2017 Dec;48(12) *shared  first authorship (Review)
  3. Pace M, Adamantidis A. Bassetti C. Role of REM sleep and melanin concentrating hormone in the neuroprotective effect of sleep deprivation pre-ischemia. PLoS One. 2017 Jan 6;12(1) 
  • § corresponding author
  1. Pace M, Baracchi F, Gao B, Bassetti C. Identification of sleep-modulated pathways involved in neuroprotection from stroke. Sleep. 2015 Nov 1;38(11)
  2. Notturno F,* Pace M*, Zappasodi F, Cam E, Bassetti C, Uncini A. Neuroprotective effect of cathodal transcranial direct current stimulation in a rat stroke model. J Neurol Sci. 2014 Jul 15;342(1-2) *sharedfirst authorship
  3. Notturno F*, Pace M*, De Angelis MV, Caporale CM, Giovannini A, Uncini A.Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene.J Neuroimmunol. 2008 Jul 15;197(2):124-7. *sharedfirst authorship

Awards

Prizes and Awards 

I was awarded the session on basic neurology at the 2nd Congress of the European Academy of Neurology. 26-31 May 2016 Copenhagen, Denmark “Role of REM sleep and melanin-concentrating hormone in the neuroprotective effect of sleep deprivation pre-ischemia preconditioning”

I was awarded a European Sleep Research Society (ESRS) Travel Grant for Early Career Researchers: at the laboratory of Prof. Pierre-Hervé Luppi, Faculté de Médecine Laënnec, Lyon, France  (2014) 

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