IIT People Search

Ilaria Colombi

Researcher
Researcher
Brain Development and Disease
Ilaria Colombi
Research center
Biografia

Biomedical engineer and neuroscientist with expertise in neural engineering, electrophysiology, calcium imaging, and computational neuroscience.

I graduated in Biomedical Engineering from the University of Genoa in 2012 and obtained a Master’s Degree in Bioengineering in 2015 (110/110 cum laude, with recommendation for publication). In 2018, I completed a PhD in Neuroscience at the Italian Institute of Technology under the supervision of Dr. Michela Chiappalone. My PhD thesis was awarded the 17th Massimo Grattarola Prize by the Italian National Group of Bioengineering.

I am currently a Researcher Fellow in the Brain Development and Disease group led by Dr. Laura Cancedda.

My research focuses on:

• Neuropharmacological studies using Micro-Electrode Arrays (MEAs) in neuronal cultures and brain slices

• Multichannel neural signal analysis and algorithm development

• In vivo calcium imaging for investigating neural circuit dynamics

• Machine learning approaches for neural data analysis and spatial coding

• Emerging experience in proteomics data analysis and integration with neuroscience datasets

Since 2022, my work has focused on spatial coding in the hippocampus, particularly on place cells and the neural mechanisms underlying spatial representation. My research aims to understand how spatial information is encoded in the brain and how these processes are altered in neurological disorders, including Down syndrome, or modulated by pharmacological treatments.



Education

Title: PhD in Neuroscience
Institute: Università degli Studi di Genova
Location: genova
Country: italy
From: 2015 To: 2019

Title: Bioengineering
Institute: Università degli Studi di Genova
Location: Genova
Country: Italy
From: 2012 To: 2015

Title: Biomedical Engineering
Institute: Università degli Studi di Genova
Location: genova
Country: Italy
From: 2008 To: 2012

All Publications
2024
Colombi I., Rastogi M., Parrini M., Alberti M., Potenzieri A., Chellali M.M., Rosati S., Chiappalone M., Nanni M., Contestabile A., Cancedda L.
Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal network scales and developmental stages in health and disease
iScience, vol. 27, (no. 4)
2023
Savardi A., Colombi I., Alberti M., Parrini M., Ziogas I., Borgogno M., De Vivo M., Contestabile A., Cancedda L.
Role of Intracellular Chloride Accumulation in Down Syndrome Physiopathology and Therapeutic Strategies
XXI Telethon Scientific Convention
Poster Conference
2021
Tinarelli F., Ivanova E., Colombi I., Barini E., Balzani E., Garcia C.G., Gasparini L., Chiappalone M., Kelsey G., Tucci V.
Cell–cell coupling and DNA methylation abnormal phenotypes in the after-hours mice
Epigenetics and Chromatin, vol. 14, (no. 1)
2021
Dominguez-Morales J.P., Buccelli S., Gutierrez-Galan D., Colombi I., Jimenez-Fernandez A., Chiappalone M.
Real-time detection of bursts in neuronal cultures using a neuromorphic auditory sensor and spiking neural networks
Neurocomputing, vol. 449, pp. 422-434
2021
Parrini M., Naskar S., Alberti M., Colombi I., Morelli G., Rocchi A., Nanni M., Piccardi F., Charles S., Ronzitti G., Mingozzi F., Contestabile A., Cancedda L.
Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome
Molecular Therapy, vol. 29, (no. 10), pp. 3072-3092
Dissemination
2017
Panuccio G., Chiappalone M., Colombi I.
Da grande voglio fare il neuroscienziato
Istituto Comprensivo Sanvitale Fra Salimbene
Outreach
Scientific Talks
2024
Contestabile A., Piccardi F., Colombi I., Cancedda L.
Unraveling deficits in neural encoding of space in Down syndrome mice
T21RS International Conference
Conference
Awards and Achievements
2019
Colombi I.
PhD thesis award in Neuroengineering "MASSIMO GRATTAROLA" (17^ Ed.)