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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
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About

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
2021
Boi F., Locarno A., Ribeiro J. F., Orban G., Tonini R., Angotzi G. N., Berdondini L.
Coupling High-density SiNAPS CMOS-based Neural Recording Probes with Optogenetic Light Stimulation
50th SFN Annual Meeting, Chicago (IL, USA)
Abstract Report Conference
2021
Boi F., Locarno A., Ribeiro J. F., Orban G., Tonini R., Angotzi G. N., Berdondini L.
Coupling SiNAPS High-density Neural Recording CMOS-Probes with Optogenetic Light Stimulation
IEEE Biomedical Circuits and Systems Conference
Conference Paper Conference
2021
Peters K.Z., Cheer J.F., Tonini R.
Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System
Trends in Neurosciences, vol. 44, (no. 6), pp. 464-477
Review Journal
2021
Pagani M., Barsotti N., Bertero A., Trakoshis S., Ulysse L., Locarno A., Miseviciute I., De Felice A., Canella C., Supekar K., Galbusera A., Menon V., Tonini R., Deco G., Lombardo M.V., Pasqualetti M., Gozzi A.
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
Nature Communications, vol. 12, (no. 1)
Article Journal
2021
Boender A.J., Bontempi L., Nava L., Pelloux Y., Tonini R.
Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2
Biological Psychiatry, vol. 89, (no. 11), pp. 1045-1057
Article Journal