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Luca Pandolfini

Researcher
Researcher
Non-coding RNAs and RNA-based therapeutics
Telefono
Indirizzo
Research center
Interests
Biografia

Bio & Interests

I got my M.Sc. and Ph.D. in Scuola Normale Superiore di Pisa, Italy, then I moved to the UK to conduct my post-doctoral studies at the Gurdon Institute in Cambridge. Since 2020 I have been working as an independent researcher at Istituto Italiano di Tecnologia, Italy, focusing on nervous system development and regeneration. My lab strongly relies on multiple second- and third-generation sequencing approaches to dissect non-canonical model organisms from a developmental functional genomics point of view. 
In particular, I am committed to leveraging the power of long-read sequencing to understand the molecular mechanisms of (neuro)developmental processes of health and environmental interest.

Key Scientific Questions:

  1. How we can bolster developmental, evolutionary and conservation biology with third-generation genomics tools​
  2. What is the transcriptional foundation of neural regeneration, and how is it lost in higher vertebrates
Education

Title: PhD in Neurobiology
Institute: Scuola Normale Superiore di Pisa
Location: Pisa
Country: Italy
From: 2011 To: 2015

Title: Master’s degree in Molecular and Cell Biology
Institute: Scuola Normale Superiore di Pisa
Location: Pisa
Country: Italy
From: 2009 To: 2011

Experience External

Title: Research Associate
Institute: Gurdon Institute - University of Cambridge
Location: Cambridge
Country: United Kingdom
From: 2015 To: 2019

Top Publications
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani L., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
LINE-1 regulates cortical development by acting as long non-coding RNAs
Nature Communications, vol. 14, (no. 1)
2023
Pierattini B., D'Agostino S., Bon C., Peruzzo O., Alendar A., Codino A., Ros G., Persichetti F., Sanges R., Carninci P., Santoro C., Espinoza S., Valentini P., Pandolfini L., Gustincich S.
SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides
Molecular Therapy - Nucleic Acids, vol. 32, pp. 402-414
2022
Dunville K., Tonelli F., Novelli E., Codino A., Massa V., Frontino A.M., Galfrè S., Biondi F., Gustincich S., Caleo M., Pandolfini L., Alia C., Cremisi F.
Laminin511 and WNT signalling sustain prolonged expansion of hiPSC-derived hippocampal progenitors.
Development (Cambridge)
2022
Valentini P., Pierattini B., Zacco E., Mangoni D., Espinoza S., Webster N.A., Andrews B., Carninci P., Tartaglia G.G., Pandolfini L., Gustincich S.
Towards SINEUP-based therapeutics: Design of an in vitro synthesized SINEUP RNA
Molecular Therapy - Nucleic Acids, vol. 27, pp. 1092-1102
Article Journal
2021
Leger A., Amaral P.P., Pandolfini L., Capitanchik C., Capraro F., Miano V., Migliori V., Toolan-Kerr P., Sideri T., Enright A.J., Tzelepis K., van Werven F.J., Luscombe N.M., Barbieri I., Ule J., Fitzgerald T., Birney E., Leonardi T., Kouzarides T.
RNA modifications detection by comparative Nanopore direct RNA sequencing
Nature Communications, vol. 12, (no. 1)
All Publications
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani F., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
L1 RNAs regulate cortical development by tuning PRC2 activity
EMBL Symposium: Brain genome: regulation, evolution and function
Poster Conference
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani L., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
LINE-1 regulates cortical development by acting as long non-coding RNAs
Nature Communications, vol. 14, (no. 1)
2023
Pierattini B., D'Agostino S., Bon C., Peruzzo O., Alendar A., Codino A., Ros G., Persichetti F., Sanges R., Carninci P., Santoro C., Espinoza S., Valentini P., Pandolfini L., Gustincich S.
SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides
Molecular Therapy - Nucleic Acids, vol. 32, pp. 402-414
2022
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani L., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G.G., Sanges R., Gustincich S.
L1 RNAs regulate cortical development by tuning PRC2 activity
SIBBM 2022 Frontiers in Molecular Biology The RNA World 3.0
Poster Conference
2022
Dunville K., Tonelli F., Novelli E., Codino A., Massa V., Frontino A.M., Galfrè S., Biondi F., Gustincich S., Caleo M., Pandolfini L., Alia C., Cremisi F.
Laminin511 and WNT signalling sustain prolonged expansion of hiPSC-derived hippocampal progenitors.
Development (Cambridge)
Dissemination
2023
Pandolfini L.
Neurogenesi e neoblasti in planaria
Frontiere della Biologia dello Sviluppo del Sistema Nervoso - Scuola Normale Superiore e Accademia dei Lincei - 5 Maggio 2023
Outreach
Scientific Talks
2023
Pandolfini L., Cilingir G., Codino A., Castellano L., Pisano C., Castillo De Spelorzi YC., Henzen E., Vozzi D., Campigli Di Giammartino D., Gustincich S., Grossen C.
From genome assembly to epigenome characterisation: a nanopore journey in the footsteps of an endangered tortoise
ONT London Calling 2023 - May 18th-19th 2023
Conference
2023
Pandolfini L., Cilingir G., Codino A., Castellano L., Pisano C., Castillo De Spelorzi YC., Henzen E., Vozzi D., Campigli Di Giammartino D., Gustincich S., Grossen C.
Tortoise Conservation Genomics
Nanopore Day 2023 - Bologna 19th Sep 2023
Conference
2022
Codino A., La Rosa L., Pisano C., Gustincich S., Pandolfini L.
Pharmacological activation of Notch signalling pathway impairs head regeneration and locomotion in the asexual Schmidtea mediterranea
5th European Meeting on Planarian Biology - Sant Feliu de Guíxols - October 2nd –4th , 2022
Conference
2022
Pandolfini L., Rink J., Ivankovic M., Brand J., Rozanski A., Brochier T., Grohme M., Winkler S., Pippel M., Brown T., Marques A.
The new chromosome-scale S. mediterranea reference genome assembly and annotations—an update
5th European Meeting on Planarian Biology - Sant Feliu de Guíxols - October 2nd –4th , 2022
Conference