Center for Translational Neurophysiology of Speech and Communication

Center for Translational Neurophysiology of Speech and Communication

The aim of the Center for Translational Neurophysiology of Speech and Communication CTNSC@UniFe is twofold. On one hand, we are studying how the brain builds communicative and linguistic representations. On the other hand, we are designing new brain interfaces, specifically conceived for human use, to transduce and computationally decode neural signals. A focus of the Center is on communication because we believe that many paralyzing pathologies require, at first, the restoring of an efficient communicative flow between the patient and the environment.

To this purpose, we are studying the mechanisms by which the brain processes and understands the communicative behaviors of other individuals to efficiently decode the brain signals related to communicative intentions. We are applying innovative and biologically-compatible technologies to the problem of automatic speech and action recognition (Speech and Communication Team) and we are designing a new generation of brain electronic devices characterized by reduced invasiveness, improved resolution, ultrasensitivity and capability to record and stimulate brain regions (Neurotechnologies Team).

In summary, with a critical focus on translational methodologies (single unit recordings, Micro-ECoG, fMRI, EEG, TMS), our research goal is to advance knowledge on brain functioning to help building the next generation of brain-computer interfaces. The group research activities span from basic research to applied one along three main research lines:

  • Design and fabrication of long-term stable neural interfaces with high signal-to-noise ratio and spatio-temporal resolution.
  • Research on brain centers and circuits involved in action/speech understanding
  • Research on new efficient methods for automatic speech recognition from audio and multimodal signals (e.g., audio-visual)

Collaborations with other National and International labs are fundamental. A particularly intense collaboration is running between CTNSC@UniFe and the Neurosurgery Unit of Udine Hospital.



CTNSC@UniFe hosts state-of-the-art facilities for motion capture, neurophysiology, histology, cell culture, organic electronics, electrochemistry, materials and devices characterization.

  • Neuronavigated Transcranial Magnetic Stimulation, High density Electroencephalography, Eye-tracking, Optical Motion Tracking and ElectroMagnetic Articulography
  • Tethered and wireless multichannel neural recording and stimulation, Neuron Tracing Fluorescence Microscopy, Histology Sectioning Microtome, Primary Cells Culture facilities
  • Galvanostats/Potentiostats, Electropolymerization, High Resolution Optical Microscopy, LCR meter, Electrometers, Dual Source Meters, Scanning Probe Microscope, Probe station, Contact Angle Measurement, Plasma, Profilometer;
  • Processing/fabrication/characterization line for organic electronics materials and devices: high-vacuum chambers for metal evaporation and organic thin film sublimation; glove boxe with spin coating; dip coating and vertical deposition.

IIT Research Structures

Research Lines

CTNSC - Contacts


Via Fossato di Mortara, 19
44121, Ferrara (FE)


IIT Publications List

Di Lauro M., Zucchini E., De Salvo A., Delfino E., Bianchi M., Murgia M., Carli S., Biscarini F., Fadiga L.
A Novel Biasing Scheme of Electrolyte-Gated Organic Transistors for Safe In Vivo Amplification of Electrophysiological Signals
Advanced Materials Interfaces
Kullmann R., Knoll G., Bernardi D., Lindner B.
Critical current for giant Fano factor in neural models with bistable firing dynamics and implications for signal transmission
Physical Review E, vol. 105, (no. 1)
Solodka K., Berto M., Ferraro D., Menozzi C., Borsari M., Bortolotti C.A., Biscarini F., Pinti M.
Detection of Neurofilament Light Chain with Label-Free Electrolyte-Gated Organic Field-Effect Transistors
Advanced Materials Interfaces
Tortorella S., Greco P., Valle F., Barbalinardo M., Foschi G., Lugli F., Dallavalle M., Zerbetto F., Bortolotti C.A., Biscarini F.
Laser Assisted Bioprinting of laminin on biodegradable PLGA substrates: Effect on neural stem cell adhesion and differentiation
Bioprinting, vol. 26
Sensi M., Migatti G., Beni V., D'Alvise T.M., Weil T., Berto M., Greco P., Imbriano C., Biscarini F., Bortolotti C.A.
Monitoring DNA Hybridization with Organic Electrochemical Transistors Functionalized with Polydopamine
Macromolecular Materials and Engineering