CGS@SEMM - Milano

Center for Genomic Science - Milano

The Center for Genomic Science applies modern genomic technologies towards a better understanding of complex biological processes and diseases, with particular emphasis on Cancer.

The Center is located within the IFOM-IEO Campus in Milan, one of the largest and most vibrant cancer research communities in Europe. The Center provides state-of-the art technological platforms for functional as well as structural genomics, and benefits from all the infrastructure, technological platforms and didactic activities already present in the IFOM-IEO Campus. Our PhD program is integrated with that of SEMM, the European School of Molecular Medicine.

The mission of our Center is to identify changes in the genome that underlie the development of cancer, as well as its susceptibility to therapeutic intervention. Our general aim is to reduce pathological traits into their molecular components, which might correspond to disease markers or potential targets for pharmacological intervention. We will exploit these molecular markers and targets in order to build up strategic programs for disease prevention, early detection and treatment.

IIT Research Structures

Research Lines

CGS - Contacts


Via Adamello 16,
20139 Milano
Tel: +39 02 9437 2281
Fax +39 02 9437 5991

IIT People


IIT Publications List

Ugolini C., Mulroney L., Leger A., Castelli M., Criscuolo E., Williamson M.K., Davidson A.D., Almuqrin A., Giambruno R., Jain M., Frigè G., Olsen H., Tzertzinis G., Schildkraut I., Wulf M.G., Corrêa I.R., Ettwiller L., Clementi N., Clementi M., Mancini N., Birney E., Akeson M., Nicassio F., Matthews D.A., Leonardi T.
Nanopore ReCappable sequencing maps SARS-CoV-2 5' capping sites and provides new insights into the structure of sgRNAs
Nucleic Acids Research
Simeone I., Rubolino C., Noviello T.M.R., Farinello D., Cerulo L., Marzi M.J., Nicassio F.
Prediction and pan-cancer analysis of mammalian transcripts involved in target directed miRNA degradation
Nucleic Acids Research, vol. 50, (no. 4), pp. 2019-2035
Savorani C., Malinverno M., Seccia R., Maderna C., Giannotta M., Terreran L., Mastrapasqua E., Campaner S., Dejana E., Giampietro C.
A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition
Journal of Cell Science, vol. 134, (no. 15)
Bido S., Muggeo S., Massimino L., Marzi M.J., Giannelli S.G., Melacini E., Nannoni M., Gambare D., Bellini E., Ordazzo G., Rossi G., Maffezzini C., Iannelli A., Luoni M., Bacigaluppi M., Gregori S., Nicassio F., Broccoli V.
Author Correction: Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity (Nature Communications, (2021), 12, 1, (6237), 10.1038/s41467-021-26519-x)
Nature Communications, vol. 12, (no. 1)
Furlan M., Delgado-Tejedor A., Mulroney L., Pelizzola M., Novoa E.M., Leonardi T.
Computational methods for RNA modification detection from nanopore direct RNA sequencing data
RNA Biology