My main research interest is understanding the mechanisms and regulation of DNA, RNA, and protein modifications. Presently, I have a particular interest in developing methods that support the detection and understanding of these modified sites. Nanopore sequencing currently has the capabilities to detect RNA and DNA modifications. I am working on developing algorithms which can better classify the presence of these modified nucleotides in the ionic current signal.
Research center
CGS@SEMM
Biografia
Education
Title: PhD
Institute: University of California Santa Cruz
Location: Santa Cruz
Country: United States
From: 2012 To: 2020
Title: Bachelor
Institute: University of California Santa Cruz
Location: Santa Cruz
Country: United States
From: 2008 To: 2012
All Publications
2024
Mulroney L., Coscujuela-Tarrero L., Maragno P., Rubolino C., Maestri S., Furlan M., Marzi M.J., Fitzgerald T., Leonardi T., Pelizzola M., Birney E., Nicassio F.
A comprehensive survey of RNA modifications in a human transcriptome
bioRxiv
2024
Maestri S., Furlan M., Mulroney L., Tarrero L.C., Ugolini C., Pozza F.D., Leonardi T., Birney E., Nicassio F., Pelizzola M.
Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing
Briefings in Bioinformatics, vol. 25, (no. 2)
2023
Giambruno R., Zacco E., Ugolini C., Vandelli A., Mulroney L., DOnghia M., Giuliani B., Criscuolo E., Castelli M., Clementi N., Clementi M., Mancini N., Bonaldi T., Gustincich S., Leonardi T., Tartaglia G., Nicassio F.
Discovering host protein interactions specific for SARS-CoV-2 RNA genome
Molecular Therapy - Nucleic Acids
2023
Giambruno R., Zacco E., Ugolini C., Vandelli A., Mulroney L., D'Onghia M., Giuliani B., Criscuolo E., Castelli M., Clementi N., Clementi M., Mancini N., Bonaldi T., Gustincich S., Leonardi T., Tartaglia G.G., Nicassio F.
Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome
Molecular Therapy - Nucleic Acids, vol. 34
2023
Mulroney L., Birney E., Leonardi T., Nicassio F.
Using Nanocompore to Identify RNA Modifications from Direct RNA Nanopore Sequencing Data
Current Protocols, vol. 3, (no. 2)
Colleagues of Genomic Science
