IIT Publications Search

Pubblicazioni
2024
Myers S.H., Poppi L., Rinaldi F., Veronesi M., Ciamarone A., Previtali V., Bagnolini G., Schipani F., Ortega Martinez J.A., Girotto S., Di Stefano G., Farabegoli F., Walsh N., De Franco F., Roberti M., Cavalli A.
An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer
European Journal of Medicinal Chemistry, vol. 265
2023
Poppi L., Myers S.H., Previtali V., Rinaldi F., Farabegol F., Di Stefano G., Walsh N., Roberti M., Cavalli A.
A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer
EACR
DOI 10.1002/1878-0261.13471 Poster Conference
2023
Rinaldi F., Bernetti M., Bresciani V., Girotto S., Cavalli A.
Dissecting the BRCA2 - RAD51 interaction by integrating computational and experimental biophysics
EMBO Practical Course Integrative modelling of protein interactions
Poster Conference
2023
Rinaldi F., Bernetti M., Bresciani V., Girotto S., Cavalli A.
Integration of computational and experimental biophysics reveals novel insights on the BRCA2 - RAD51 interaction
EMBO Workshop: Computational structural biology
Poster Conference
2023
Rinaldi F., Schipani F., Balboni B., Catalano F., Marotta R., Myers S.H., Previtali V., Veronesi M., Scietti L., Cecatiello V., Pasqualato S., Ortega J.A., Girotto S., Cavalli A.
Isolation and Characterization of Monomeric Human RAD51: A Novel Tool for Investigating Homologous Recombination in Cancer
Angewandte Chemie - International Edition
2023
Balboni B., Rinaldi F., Previtali V., Ciamarone A., Girotto S., Cavalli A.
Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies
Cancers, vol. 15, (no. 6)
2022
Myers S. H., Previtali V., Poppi L., Rinaldi F., Schipani F., Ortega J. O., De Franco F., Veronesi M., Pellicciari R., Roberti M., Girotto S., Di Stefano G., Cavalli A.
Identification and subsequent development of RAD51 inhibitors as potential tools in exploring BRCA2-PARP mediated synthetic lethality
ACS Spring 2022 meeting
Poster Conference
2022
Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A.
Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer
ACS Spring 2022 meeting
Poster Conference
2022
Schipani F., Manerba M., Marotta R., Poppi L., Gennari A., Rinaldi F., Armirotti A., Farabegoli F., Roberti M., Di Stefano G., Rocchia W., Girotto S., Tirelli N., Cavalli A.
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination
International Journal of Molecular Sciences, vol. 23, (no. 15)
2022
Rinaldi F., Schipani F., Scietti L., Girotto S., Cavalli A.
Unveiling the molecular mechanism of BRCA2-RAD51 interaction to tackle cancer onset
EMBO Practical Course "Characterization of macromolecular complexes by integrative structural biology"
Poster Conference
2019
Hutmacher C., Volta L., Rinaldi F., Murer P., Myburgh R., Manz M.G., Neri D.
Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia
Leukemia Research, vol. 84