The goal of this project is improving the LOCUAZ Binder Design Platform which supports modifications that could increase nanobody-antigen affinity. 

Developing high-affinity binders against specific antigens is challenging and requires extensive experimental screening. We designed a computational method that can accelerate this process, offering a computationally guided approach to antibody fragment engineering.

We are currently complementing our computational efforts by performing experimental tests of the platform’s predictions.

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In this project we investigated, by means of molecular dynamics simulations, how a re-engineered protein, acting as biological nanopore, can be used to recognize the sequence of a translocating peptide by sensing the shape of individual amino-acids. This work was published on Nano Research.