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Nanotechnology for Precision Medicine

Nanotechnology for Precision Medicine

The mission of the Laboratory of Nanotechnology for Precision Medicine is to

  • rationally design polymeric nanoconstructs for multi-modal imaging (PET, MRI and optical imaging) and combination therapy (chemotherapeutic and anti-inflammatory molecules, biologicals) in cancer, cardiovascular and neurological diseases
  • fabricate microfluidic chips for the rapid screening of novel molecular and nano-based therapeutic agents and for elucidating new biophysical mechanisms in diseases;
  • develop multi-scale, hierarchical computational models for optimizing the therapeutic efficacy of nanoconstructs;
  • organize dissemination activities at the interface between engineering and biomedical sciences;
  • promote the professional development of lab members in a highly multi-disciplinary environment.

Activities

Activities

Our laboratory is divided in sub-groups working on the development of:

  • Spherical Polymeric Nanoconstructs (from 20 to 200 nm);
  • Discoidal Polymeric Nanoconstructs (from 800 to 2,000 nm, exhibiting a variety of geometries and mechanical stiffnesses);
  • polymeric microPlates (> 20 µm);
  • Microfluidics for organ-on-a-chip;
  • Computational tools for vascular and extra-vascular modeling.

The laboratory involves scientists and students with a variety of backgrounds including biomedical, mechanical and electrical engineers, computational scientists, physicists, chemists, biotechnologists and biologists.

Laboratories

Laboratories

Our research laboratory combines state-of-the-art technology with the highest standards of safety, flexibility and sustainability. Laboratory members, trainees and visitors have access to equipment for the synthesis, physico-chemical, magnetic, and biological characterization of nanoconstructs and for the design and realization of complex micro-fluidic systems.
Lab core instrumentation includes DLS, Multisizer Coulter Counter, HPLC and UPLC, bench-top relaxometers (0.5, 1 and 1.4T) and SQUID. Furthermore, laboratory members have access to Institutional facilities comprising i) a Clean Room Facility equipped with Optical and Electron beam lithographic systems, SEM, TEM and AFM; ii) Microscopy Nikon Centre equipped for super-resolved optical imaging and live cell imaging; iii) pre-clinical imaging facility equipped with an IVIS Spectrum, 3T GE MRI scanner and micro-PET system.

Collaborations

Collaborations

The Laboratory of Nanotechnology for Precision Medicine has active collaborations with the three major Research Hospitals in Genova (Galliera Hospital, Cancer Center at the San Martino Hospital and Gaslini Children Hospital). Also, the Laboratory has ongoing collaborations with several Academic and Research Institutions in Italy, Europe and World wide.

Covers

Journal Covers

IIT Publications List

Publications
2022
Manghnani P.N., Di Francesco V., Panella La Capria C., Schlich M., Miali M.E., Moore T.L., Zunino A., Duocastella M., Decuzzi P.
Preparation of anisotropic multiscale micro-hydrogels via two-photon continuous flow lithography
Journal of Colloid and Interface Science, vol. 608, pp. 622-633
2022
Felici A., Di Mascolo D., Ferreira M., Lauciello S., Bono L., Armirotti A., Pitchaimani A., Palange A.L., Decuzzi P.
Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth
Nano Research, vol. 15, (no. 1), pp. 482-491
2021
Stinnett G., Taheri N., Villanova J., Bohloul A., Guo X., Esposito E.P., Xiao Z., Stueber D., Avendano C., Decuzzi P., Pautler R.G., Colvin V.L.
2D Gadolinium Oxide Nanoplates as T1 Magnetic Resonance Imaging Contrast Agents
Advanced healthcare materials, vol. 10, (no. 11)
2021
Rancati S., Pereira R.C., Schlich M., Macchi F., Pelizzoli R., Braccia C., Lo Van A., Pons-Espinal M., Palange A.L., Bajetto A., Daga A., Armirotti A., Florio T., Decuzzi P., De Pietri Tonelli D.
A nanoformulated 11-microRNA pool synergistically modulates tumor cell invasion and growth in orthotopic glioblastoma murine model
EMBL in Italy 2021: A Brave New World of RNA, 20-21 May 2021 Virtual at the Italian Institute of Technology (IIT), Genoa
2021
Barbato M.G., Pereira R.C., Mollica H., Palange A., Ferreira M., Decuzzi P.
A permeable on-chip microvasculature for assessing the transport of macromolecules and polymeric nanoconstructs
Journal of Colloid and Interface Science, vol. 594, pp. 409-423