The D3 PharmaChemistry Line possesses competences and technologies to start and advance drug discovery projects and to provide support to the progression of projects in the area of drug delivery and diagnostics.
The Line is comprised of various laboratories and groups with a broad range of competences including Synthetic and Medicinal Chemistry, Analytical and Bioanalytical Chemistry, NMR Spectroscopy, in vitro and in vivo Pharmacology, Nanotoxicology, and Lab Automation and Data Management. Thanks to those competences and state-of-the-art instruments, the D3 PharmaChemistry can undertake various tasks such as synthesis and characterization of potential new drugs, development in vitro assays to evaluate the biological activity and/or toxicity of compounds and materials, assessment of the efficacy of drugs and drug delivery systems in animal models of disease, quantification of drugs in biological fluids and tissues, and search for potential biomarkers of activity and/or toxicity of small molecules and new materials. Leveraging on existing competences, the Line applies a multidisciplinary approach to support specific research needs of IIT groups in the area of life sciences and intelligent drug delivery systems.
- Graphene Labs (V. Pellegrini, F. Benfenati): Metabolomics of neurons exposed to graphene
- Smart Materials (A. Athanassiou): In vitro/in vivo characterization of new materials for biomedical applications
- Nanobiointeractions and Nanodiagnostics (P.P. Pompa): In vivo characterization of nanomaterials for the
- Nano Carbon Materials (S. Giordani): In vitro characterization of carbon nanomaterials
- Istituto Giannina Gaslini (N. Pedemonte - L. Galietta): Task Force for Cystic Fibrosis project - Discovery of new drugs for the treatment of cystic fibrosis
- Istituto Giannina Gaslini (R. Ravazzolo): New treatment strategies for Fibrodysplasia Ossificans Progressiva
- Telethon Institute of Genetics and Medicine (TIGEM – L. Galietta): New therapeutic targets in cystic fibrosis lung disease
- University of Genoa (DIMES, R. Cancedda): Proteomics studies on exosomes