Ongoing projects:
Enhancing Nanobody Specificity
Improving the LOCUAZ Binder Design Platform which supports modifications that could increase nanobody-antigen affinity.
We are currently complementing our computational efforts by performing experimental tests of the platform’s predictions.
Completed projects:
Adaptive nanopores: A bioinspired label-free approach for protein sequencing and identification
In this project we investigated, by means of molecular dynamics simulations, how a re-engineered protein, acting as biological nanopore, can be used to recognize the sequence of a translocating peptide by sensing the shape of individual amino-acids. This work was published on Nano Research.