Our main focus is to understand the role played by RNA molecules in protein networks. Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and will open up therapeutic avenues for the treatment of a broad range of human disorders. We aim to discover the involvement of RNA molecules in regulatory networks controlling protein production and we are interested in understanding mechanisms whose alteration lead to aberrant aggregation, such as the one observed in amyloid diseases. We have recently observed that interaction between proteins and RNAs induce feedback loops that are crucial in protein homeostasis. We also found that specific RNAs promote phase separation of proteins in the cytosol and nucleus and we are designing synthetic RNA molecules to manipulate the formation of complexes.
RNA Systems Biology
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Barbara Denisi Support Administrative Assistant Neuroscience and Behaviour Nanotechnologies for Neurosciences Multiscale and Quantum Simulations Non coding RNAs in Physiology and Pathology Neuroscience and society RNA Systems Biology Procurement Directorate Res. Line Admin. Support Life Science Neuroscience of Perception and Action