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Mattia Pelizzola

Affiliated Researcher
Genomic Science
Research center

I am a computational biologist with background in biotechnology and Associate Professor at the Dept. of Biotechnology and Biosciences, Milano-Bicocca University. I lead a research group studying how co- and post- transcriptional events shape gene expression programs. We employ an interdisciplinary approach combining cutting edge experimental and computational methods, including the profiling of nascent and modified RNA, single-molecule Nanopore sequencing, and mathematical modelling (https://www.iit.it/it/web/genomic-science/pelizzola).


Title: PhD in Complexity in Post-Genomic Biology
Institute: University of Torino
Location: Torino
Country: Italy
From: 2004 To: 2006

Title: Master in Bioinformatics
Institute: Milano-Bicocca University
Location: Milano
Country: Italy
From: 2002 To: 2003

Title: Master’s degree in Industrial Biotechnologies
Institute: Milano-Bicocca University
Location: Milano
Country: Italy
From: 1995 To: 2001

Experience External

Title: Postdoctoral Research Associate
Institute: Salk Institute for Biological Science
Location: La Jolla, CA
Country: USA
From: 2009 To: 2011

Title: Postdoctoral Research Associate
Institute: Yale University
Location: New Haven , CT
Country: USA
From: 2007 To: 2009

Top Publications
De Pretis S., Kress T.R., Morelli M.J., Sabo A., Locarno C., Verrecchia A., Doni M., Campaner S., Amati B., Pelizzola M.
Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation
Genome Research, vol. 27, (no. 10), pp. 1658-1664
Sabo A., Kress T.R., Pelizzola M., De Pretis S., Gorski M.M., Tesi A., Morelli M.J., Bora P., Doni M., Verrecchia A., Tonelli C., Faga G., Bianchi V., Ronchi A., Low D., Muller H., Guccione E., Campaner S., Amati B.
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
Nature, vol. 511, (no. 7510), pp. 488-492
Lister R., Pelizzola M., Kida Y.S., Hawkins R.D., Nery J.R., Hon G., Antosiewicz-Bourget J., Ogmalley R., Castanon R., Klugman S., Downes M., Yu R., Stewart R., Ren B., Thomson J.A., Evans R.M., Ecker J.R.
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
Nature, vol. 471, (no. 7336), pp. 68-73
Lister R., Pelizzola M., Dowen R.H., Hawkins R.D., Hon G., Tonti-Filippini J., Nery J.R., Lee L., Ye Z., Ngo Q.-M., Edsall L., Antosiewicz-Bourget J., Stewart R., Ruotti V., Millar A.H., Thomson J.A., Ren B., Ecker J.R.
Human DNA methylomes at base resolution show widespread epigenomic differences
Nature, vol. 462, (no. 7271), pp. 315-322
All Publications
Maestri S., Furlan M., Mulroney L., Tarrero L.C., Ugolini C., Pozza F.D., Leonardi T., Birney E., Nicassio F., Pelizzola M.
Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing
Briefings in Bioinformatics, vol. 25, (no. 2)
Kumar N. H., Kluever V., Barth E., Krautwurst S., Furlan M., Pelizzola M., Marz M., Fornasiero E.F.
Comprehensive transcriptome analysis reveals altered mRNA splicing and post-transcriptional changes in the aged mouse brain
Nucleic Acids Research
Dermentzaki G., Furlan M., Tanaka I., Leonardi T., Rinchetti P., Passos P.M.S., Bastos A., Ayala Y.M., Hanna J.H., Przedborski S., Bonanomi D., Pelizzola M., Lotti F.
Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration
Cell Reports, vol. 43, (no. 4)
Article Journal
Leone M., Galeota E., Masseroli M., Pelizzola M.
Identification, semantic annotation and comparison of combinations of functional elements in multiple biological conditions
Bioinformatics, vol. 38, (no. 5), pp. 1183-1190
Lepesant J.M.J., Iampietro C., Galeota E., Auge B., Aguirrenbengoa M., Merce C., Chaubet C., Rocher V., Haenlin M., Waltzer L., Pelizzola M., Di Stefano L.
A dual role of dLsd1 in oogenesis: Regulating developmental genes and repressing transposons
Nucleic Acids Research, vol. 48, (no. 3), pp. 1206-1224