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Irene Farabella

Researcher - Principal Investigator
Integrative Nuclear Architecture
Research center

Irene Farabella received an MSc in Medical Biotechnology from the University of Milano- Bicocca, Italy, in 2008 after a visiting period sponsored by a fellowship from the EXTRA PLUS Program financed by Fondazione Cariplo at the Centre for Molecular and Biomolecular Informatics (CMBI), Nijmegen supervised by Prof. Gert Vriend and Prof. Marialuisa Lavitrano. 

In 2013, she got a PhD sponsored by a Wellcome Trust Funded PhD studentship in Structural Biology working at ISMB (UCL/Birkbeck College, London, UK) under the supervision of Prof. Maya Topf and Prof. Gabriel Waksman.

For her postdoc training, she joined Marc Marti-Renom’s lab at the Centre Nacional d’ Anàlisi Genòmica – Centre de Regulació Genòmica (CNAG-CRG), Barcelona as a Juan de la Cierva Incorporación Postdoctoral Fellow. During this time, she also worked as a researcher in the C.-Ting Wu’s lab at Harvard Medical School.

In September 2022 she established her independent Armenise-Harvard Integrative Nuclear Architecture Lab at the Fondazione Istituto Italiano di Tecnologia (IIT) in the Center for Human Technologies in Genoa, where she will investigate the 3D genome structural variability at the nanoscale.

Top Publications
Harris H.L., Gu H., Olshansky M., Wang A., Farabella I., Eliaz Y., Kalluchi A., Krishna A., Jacobs M., Cauer G., Pham M., Rao S.S.P., Dudchenko O., Omer A., Mohajeri K., Kim S., Nichols M.H., Davis E.S., Gkountaroulis D., Udupa D., Aiden A.P., Corces V.G., Phanstiel D.H., Noble W.S., Nir G., Di Pierro M., Seo J.-S., Talkowski M.E., Aiden E.L., Rowley M.J.
Chromatin alternates between A and B compartments at kilobase scale for subgenic organization
Nature Communications, vol. 14, (no. 1)
Flores V., Farabella I., Nir G.
Genome-wide tracing to decipher nuclear organization
Current Opinion in Cell Biology, vol. 82
Mendieta-Esteban J., Di Stefano M., Castillo D., Farabella I., Marti-Renom M.A.
3D reconstruction of genomic regions from sparse interaction data
NAR Genomics and Bioinformatics, vol. 3, (no. 1)
Farabella I., Di Stefano M., Soler-Vila P., Marti-Marimon M., Marti-Renom M.A.
Three-dimensional genome organization via triplex-forming RNAs
Nature Structural and Molecular Biology, vol. 28, (no. 11), pp. 945-954
Nir G., Farabella I., Perez Estrada C., Ebeling C.G., Beliveau B.J., Sasaki H.M., Lee S.H., Nguyen S.C., McCole R.B., Chattoraj S., Erceg J., AlHaj Abed J., Martins N.M.C., Nguyen H.Q., Hannan M.A., Russell S., Durand N.C., Rao S.S.P., Kishi J.Y., Soler-Vila P., Di Pierro M., Onuchic J.N., Callahan S.P., Schreiner J.M., Stuckey J.A., Yin P., Aiden E.L., Marti-Renom M.A., Wu C.-T.
Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling
PLoS Genetics, vol. 14, (no. 12)