Piezo4Spine aims to develop a novel multifactorial therapy for spinal cord injury (SCI) conceived as a disruptive platform enabling unprecedented multiscale actuation to drive functional neural repair by more accurately tackling SCI complexity. It originally relies on the pivotal role that mechanotransduction plays in the physiology and physiopathology of tissue and organ functions, never explored before for SCI. We will develop a 3D bioprinted mesh containing nanocarriers with therapeutic agents acting at two pivotal aspects of neural repair: mechanotransduction and inhibitory scarring using gene therapy strategies. Bioactive nanocarriers will base on cutting-edge nanoparticles whose release will be electrically triggered on-demand via wireless powering. Such 3D-theramesh offers a novel and exceptionally robust biomaterial for delivering agents at the lesion, controlling time and dose. Current advances on SCI therapies focus on rehabilitation, cell transplantation, drugs, biomaterials, and/or electrical stimulation. Although leading to partial sensory/motor recovery, chronic functional deficits limit daily living activities and shorten live expectancy in SCI patients, as they fail to promote successful axon regeneration at the lesion and awake lost functions. By a multidisciplinary consortium combining scientific, technological, clinical and industrial partners enriched by their interdisciplinarity, we envision to overcome limitations of current technologies by tackling multiple cellular targets involved in neural regeneration after SCI with a balanced combination of therapeutic interventions able to optimally promote functional recovery. These radical science-to-technology breakthroughs could enable, if successful, novel technologies and therapies for SCI and many other neural and non-neural pathologies in which some, but not necessarily all, of these targets are involved. Gender dimension will be implemented by ensuring that findings apply to society as a whole.
Piano Nazionale di Ripresa e Resilienza (PNRR)
Piezo-driven theramesh: A revolutionary multifaceted actuator to repair the injured spinal cord
Sommario
Persone coinvolte
Fabio Biscarini
Organic Neuroelectronics
Luciano Fadiga
Multiscale Brain Communication
Informazioni
Acronimo
Piezo4Spine
Data inizio
01/01/2023
Data fine
31/12/2026
Ruolo
Partner
Funds
European
Budget
Total budget: 486.082,50€
Total contribution: 486.082,50€
CUP J33C22001200001, ammesso a finanziamento dal MUR con Decreto Direttoriale di concessione delle agevolazioni n. 1034 del 17 giugno 2022, in risposta all’Avviso N. 3138 del 16/12/2021 che dà attuazione all’Investimento 1.4 - “Potenziamento strutture di ricerca e creazione di "campioni nazionali di R&S" su alcune Key Enabling Technologies” – nell’ambito della Missione 4 “Istruzione e ricerca”, Componente 2 “Dalla ricerca all’impresa” del Piano Nazionale di Ripresa e Resilienza.