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Gian Gaetano Tartaglia

Principal Investigator
Principal Investigator - Principal Investigator
RNA Systems Biology
Research center
I graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons supervised by Brunello Tirozzi (Physics department). Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH with Amedeo Caflisch (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011. From 2010 and until 2020 I have been PI at the Centre for Genomic Regulation (CRG) in Barcelona directed by Miguel Beato (until 2012) and Luis Serrano (since 2012), in the research program of Roderic Guigo'. I was awarded an ERC grant in 2013 for my studies on the role of coding and non-coding transcripts in regulation of amyloid genes. In 2014 I was tenured in Catalonia as ICREA professor of Life and Medical Sciences. In December 2018 I became full professor of Biochemistry in the Department of Biology at University La Sapienza. In 2019 I started to work at IIT. In 2020 I was awarded an ERC grant for the study on the composition of phase-separated assemblies. This ERC is a Synergy grant and involves collaboration with Giancarlo Ruocco and Irene Bozzoni. In march 2020 I became PI at IIT where I lead the RNA System Biology lab. Together with the official members of the group, there are also Dr. Claudia Giambartolomei and Dr. Elsa Zacco from the Non-coding RNAs and RNA-based therapeutics lab. Elsa and Claudia are the pioneers of our RNA System Biology lab and joined IIT in early 2019. Jakob Rupert, PhD student from Sapienza university, is also member of Tartaglia's lab. Edoardo Milanetti, Lorenzo Di Rienzo and Mattia Miotto, previously in Anna Tramontano's group and now working at IIT CNLS with Giancarlo Ruocco are honorary members of the lab. Since September 2020 I am MAE (Member of Academia Europaea).

Title: Clare Hall Research Fellow - Genetics and Chemistry
Institute: University of Cambridge
Location: Cambridge
Country: UK
From: 2007 To: 2010

Title: PhD - Biochemistry
Institute: University of Zurch
Location: Zuerich
Country: Switzerland
From: 2001 To: 2006

Title: MSc - Physics
Institute: University of Rome Sapienza
Location: Rome
Country: Italy
From: 1996 To: 2000


Protein-RNA Networks

Phase Separation

RNA Viruses

Computational Modelling

RNA Chemistry

All Publications
Gaziano L., Giambartolomei C., Pereira A.C., Gaulton A., Posner D.C., Swanson S.A., Ho Y.-L., Iyengar S.K., Kosik N.M., Vujkovic M., Gagnon D.R., Bento A.P., Barrio-Hernandez I., Ronnblom L., Hagberg N., Lundtoft C., Langenberg C., Pietzner M., Valentine D., Gustincich S., Tartaglia G.G., Allara E., Surendran P., Burgess S., Zhao J.H., Peters J.E., Prins B.P., Angelantonio E.D., Devineni P., Shi Y., Lynch K.E., DuVall S.L., Garcon H., Thomann L.O., Zhou J.J., Gorman B.R., Huffman J.E., O'Donnell C.J., Tsao P.S., Beckham J.C., Pyarajan S., Muralidhar S., Huang G.D., Ramoni R., Beltrao P., Danesh J., Hung A.M., Chang K.-M., Sun Y.V., Joseph J., Leach A.R., Edwards T.L., Cho K., Gaziano J.M., Butterworth A.S., Casas J.P.
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Nature Medicine, vol. 27, (no. 4), pp. 668-676
Monti M., Armaos A., Fantini M., Pastore A., Tartaglia G.G.
Aggregation is a Context-Dependent Constraint on Protein Evolution
Frontiers in Molecular Biosciences, vol. 8
Article Journal
Armaos A., Colantoni A., Proietti G., Rupert J., Tartaglia G.G.
CatRAPID omics v2.0: Going deeper and wider in the prediction of protein-RNA interactions
Nucleic Acids Research, vol. 49, (no. 1), pp. W72-W79
Article Journal
Di Rienzo L., Monti M., Milanetti E., Miotto M., Boffi A., Tartaglia G.G., Ruocco G.
Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition
Computational and Structural Biotechnology Journal, vol. 19, pp. 3006-3014
Article Journal
Battistelli C., Garbo S., Riccioni V., Montaldo C., Santangelo L., Vandelli A., Strippoli R., Tartaglia G.G., Tripodi M., Cicchini C.
Design and functional validation of a mutant variant of the LncRNA HOTAIR to counteract snail function in epithelial-to-mesenchymal transition
Cancer Research, vol. 81, (no. 1), pp. 103-113
Article Journal
Scientific Talks
Armaos A., Giambartolomei C., Tartaglia G.G.
Reconstructing protein interactions at enhancer-promoter regions in prostate cancer
American Society of Human Genetics
Vandelli A., Tartaglia G.G.
Structural analysis of SARS-CoV-2 genome and predictions of the human interactome
Doctorate School UPF Barcelona
School (Summer school, ...)
Tartaglia G.G.
The role of non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
Brixen Biophysics meeting http://www0.mi.infn.it/~tiana/bressanone-20/Welcome.html?fbclid=IwAR2qvkqzyEfq3Y-4wwfQ6Ni2oJHQEEnRT_pB8oqyR_6geS5wI0nLMqu9Onw
Tartaglia G.G.
The role of non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
Research Conference on (Epi-)Genome Architecture https://osr.kaust.edu.sa/crf/Conferences/Pages/Genome-Architecture-and-Function.aspx
Tartaglia G.G.
Aggregation, RNA-binding ability and Neurodegeneration
Universita degli Studi di Roma La Sapienza
Awards and Achievements
Tartaglia G.G.
ERC Award
Tartaglia G.G.
Member of Academia Europaea
Tartaglia G.G.
Full Professor
Tartaglia G.G.
ICREA Professor
Tartaglia G.G.