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National Center for Gene Therapy and Drugs based on RNA Technology
Abstract

The research program has two main goals: increasing the technological know-how necessary to design and deliver RNA-based and gene therapy medicinal products and identifying promising candidate drugs/genes in five major areas of human diseases (genetic diseases, cancer, metabolic/cardiovascular diseases, neurodegenerative disorders and inflammatory/infectious diseases). Two aims will thus be pursued. The first is to identify the most promising candidate targets for RNA-based drugs in five major areas of human diseases (genetic diseases, cancer, metabolic and cardiovascular, neurodegenerative, and inflammatory/infectious disorders) by supporting the progress in TRL of projects presented by highly qualified biomedical and clinical scientists (“Vertical Spokes”). The second is to build and disseminate the technological know-how necessary for designing, delivering and producing RNA drugs (“Horizontal Spokes”). For this purpose, a network of experts is created with skills covering biophysical, computational and experimental aspects of RNA biology, in order to support the activity and the competitiveness of the scientists focused on the development of RNA drugs for specific targets and simultaneously train a new generation of scientists that would ensure the implementation of the most updated RNA-based technologies.

LogoEnteFinanziatore PNRR
People involved
Stefano Gustincich
Stefano Gustincich
Non-coding RNAs and RNA-based therapeutics
Andrea Armirotti
Andrea Armirotti
Analytical Chemistry
Athanassia Athanassiou
Athanassia Athanassiou
Smart Materials
Andrea Barberis
Andrea Barberis
Synaptic Plasticity of Inhibitory Networks
Laura Cancedda
Laura Cancedda
Brain Development and Disease
Andrea Cavalli
Andrea Cavalli
Computational and Chemical Biology
Davide De Pietri Tonelli
Davide De Pietri Tonelli
Neurobiology of miRNA
Marco De Vivo
Marco De Vivo
Molecular Modeling and Drug Discovery
Alberto Diaspro
Alberto Diaspro
Nanoscopy & NIC@IIT
Stefania Girotto
Stefania Girotto
Structural Biophysics
Benedetto Grimaldi
Benedetto Grimaldi
Molecular Medicine
Paolo Netti
Paolo Netti
Bio-Logic Materials
Francesco Nicassio
Francesco Nicassio
Genomic Science
Enrica Petrini
Enrica Petrini
Neurofacility
Pier Paolo Pompa
Pier Paolo Pompa
Nanobiointeractions & Nanodiagnostics
Giancarlo Ruocco
Giancarlo Ruocco
Nanotechnologies for Neurosciences
Velia Siciliano
Velia Siciliano
Synthetic and Systems Biology for Biomedicine
Gian Gaetano Tartaglia
Gian Gaetano Tartaglia
RNA Systems Biology
Nicola Tirelli
Nicola Tirelli
Polymers and Biomaterials
Higher Education Office
Raffaella Tonini
Raffaella Tonini
Neuromodulation of Cortical and Subcortical Circuits
Valter Tucci
Valter Tucci
Genetics and Epigenetics of Behavior
Giuseppe Vicidomini
Giuseppe Vicidomini
Molecular Microscopy and Spectroscopy
Project information
RNA LOGO
Acronym
National Center for Gene Therapy and Drugs based on RNA Technology
Start date
01/11/2022
End date
31/10/2025
Role
Coordinator
Funds
National
Budget
Total budget: 8.894.229,33€
Total contribution: 8.894.229,33€
Link