Our efforts are devoted to the translation of noble metal nanomaterials to the bed-side by addressing the issue of metal persistence, in order to promote innovative and non-invasive treatments for neoplasms and infectious diseases.
By employing the ultrasmall-in-nano design, we have developed the passion fruit-like nano-architectures (WO2016/139591): an all-in-one inorganic nanomaterial able to jointly combine most of the intriguing behaviors of noble metal nanoparticles with their excretion from organism. Our main interests are related to photothermal conversion, drug delivery, photoacoustic/ultrasound imaging. In agreement with the 3R concept, we also continuously develop new 3D cancer models to test nanomaterials.
Thanks to the support of Fondazione AIRC we are especially working on combined treatments for head/neck neoplasms.
We are also involved in the development of novel nanorattle catalysts for hydrogen storage and automotive exhaust gas treatment.
IIT Publications List
Zamborlin A., Voliani V.
Gold nanoparticles as antiangiogenic and antimetastatic agents
Drug Discovery Today, vol. 28, (no. 2)
Sarogni P., Zamborlin A., Mapanao A.K., Logghe T., Brancato L., van van Zwol E., Menicagli M., Giannini N., Gonnelli A., Linsalata S., Colenbier R., Van den Bossche J., Paiar F., Bogers J., Voliani V.
Hyperthermia Reduces Irradiation-Induced Tumor Repopulation in an In Vivo Pancreatic Carcinoma Model
Che P.P., Mapanao A.K., Gregori A., Ermini M.L., Zamborlin A., Capula M., Ngadimin D., Slotman B.J., Voliani V., Sminia P., Giovannetti E.
Biodegradable Ultrasmall-In-Nano Architectures Loaded with Cisplatin Prodrug in Combination with Ionizing Radiation Induces DNA Damage and Apoptosis in Pancreatic Ductal Adenocarcinoma
Cancers, vol. 14, (no. 12)